Name: Name:Monomethyl Auristatin F
Brand: AABLOCKS
SKU: AA003574
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA003574

Chemical Name: Monomethyl Auristatin F

CAS Number: 745017-94-1

Molecular Formula: C39H65N5O8

Molecular Weight: 731.9621

MDL Number: MFCD25976742

SMILES: CN[C@H](C(=O)N[C@H](C(=O)N(C([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C)OC)OC)[C@H](CC)C)C)C(C)C)C(C)C

Properties

Form: Solid

MP: >137°C (dec.)

Storage: Keep in dry area;2-8℃;

Complexity: 1160

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 9

Heavy Atom Count: 52

Hydrogen Bond Acceptor Count: 9

Hydrogen Bond Donor Count: 4

Rotatable Bond Count: 21

XLogP3: 2.1

Literature fold

Title: Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.

Journal: Analytical chemistry20120320

Title: Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.

Journal: Bioconjugate chemistry20111019

Title: Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection.

Journal: Cancer research20090315

Title: A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.

Journal: Cancer research20081115

Title: Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination.

Journal: Bioconjugate chemistry20080801

Title: Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70.

Title: Lee JJ, et al. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4.

Title: Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics.

Title: Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

745017-94-1 | Monomethyl Auristatin F