Home Amines 149606-27-9
149606-27-9,MFCD09838692
Catalog No.:AA001LSS

149606-27-9 | L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$187.00   $131.00
- +
5mg
95%
1 week  
$386.00   $270.00
- +
10mg
95%
1 week  
$530.00   $371.00
- +
25mg
95%
1 week  
$848.00   $594.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001LSS
Chemical Name:
L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
CAS Number:
149606-27-9
Molecular Formula:
C39H67N5O6
Molecular Weight:
701.9792
MDL Number:
MFCD09838692
SMILES:
CC[C@@H]([C@H](N(C(=O)[C@H](C(C)C)NC(=O)[C@@H](N(C)C)C(C)C)C)[C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@H](C(=O)NCCc1ccccc1)C)OC)OC)C
Properties
Properties
 
Form:
Solid  
MP:
73-79℃  

Computed Properties
 
Complexity:
1060  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
50  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
20  
XLogP3:
5.2  

Literature

Title: [Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100301

Title: Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100215

Title: Efficacy of selected natural products as therapeutic agents against cancer.

Journal: Journal of natural products 20080301

Title: Comparison of the antivascular and cytotoxic activities of TZT-1027 (Soblidotin) with those of other anticancer agents.

Journal: Anti-cancer drugs 20070901

Title: Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.

Journal: Bioorganic & medicinal chemistry letters 20070601

Title: The novel microtubule-interfering agent TZT-1027 enhances the anticancer effect of radiation in vitro and in vivo.

Journal: British journal of cancer 20070521

Title: Vascular disrupting agents in clinical development.

Journal: British journal of cancer 20070423

Title: Tumor-specific antivascular effect of TZT-1027 (Soblidotin) elucidated by magnetic resonance imaging and confocal laser scanning microscopy.

Journal: Cancer science 20070401

Title: The inhibitory effect of docetaxel and p38 MAPK inhibitor on TZT-1027 (Soblidotin)-induced antivascular activity.

Journal: Anticancer research 20070101

Title: Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates.

Journal: The Journal of biological chemistry 20060414

Title: Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates.

Journal: Cancer research 20060215

Title: Reference profiling of the genomic response induced by an antimicrotubule agent, TZT-1027 (Soblidotin), in vitro.

Journal: The pharmacogenomics journal 20060101

Title: Combination effect of TZT-1027 (Soblidotin) with other anticancer drugs.

Journal: Anticancer research 20060101

Title: Antitumor activity of TZT-1027 (Soblidotin).

Journal: Anticancer research 20060101

Title: Total assignment of the (1)H- and (13)C-NMR spectra for TZT-1027 and related compounds.

Journal: Chemical & pharmaceutical bulletin 20050901

Title: [Structure-activity relationship analysis].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040401

Title: TZT-1027 elucidates antitumor activity through direct cytotoxicity and selective blockade of blood supply.

Journal: Anticancer research 20040101

Title: Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo.

Journal: Cancer science 20030901

Title: Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo.

Journal: Cancer chemotherapy and pharmacology 20020101

Title: Validation of an analytical method for a potent antitumor agent, TZT-1027, in plasma using liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011025

Title: Yamamoto N, et al. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks. Cancer Sci. 2009 Feb;100(2):316-21.

Title: Fanale D, et al. Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option? Anal Cell Pathol (Amst). 2015;2015:690916.

Title: Watanabe K, et al. Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models. Clin Cancer Res. 2010 Feb 15;16(4):1170-8.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:149606-27-9 Molecular Formula|149606-27-9 MDL|149606-27-9 SMILES|149606-27-9 L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-