Home Other Building Blocks 474645-27-7
474645-27-7,MFCD22124498
Catalog No.:AA003573

474645-27-7 | Monomethyl auristatin e

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$23.00   $16.00
- +
100mg
98%
in stock  
$150.00   $105.00
- +
250mg
98%
in stock  
$236.00   $165.00
- +
1g
98%
in stock  
$671.00   $470.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003573
Chemical Name:
Monomethyl auristatin e
CAS Number:
474645-27-7
Molecular Formula:
C39H67N5O7
Molecular Weight:
717.9786
MDL Number:
MFCD22124498
SMILES:
CN[C@H](C(=O)NC(=O)[C@@H](N(C([C@@H](CC(=O)N1CCC[C@H]1C([C@H](C(=O)N[C@@H]([C@H](c1ccccc1)O)C)C)OC)OC)[C@H](CC)C)C)C(C)C)C(C)C
Properties
Properties
 
BP:
873.5±65.0°C at 760 mmHg  
Form:
Solid  
MP:
>90°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
1100  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
51  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
20  
XLogP3:
4.1  

Downstream Synthesis Route
474645-27-7   
C31H30N2O17 
 
C64H92N6O21 

[1]AngewandteChemie-InternationalEdition,2012,vol.51,p.11606-11610    Angew.Chem.,2012,vol.124,p.11774-11778,5

474645-27-7    148580-01-2   
C60H88N6O21 

[1]EuropeanJournalofMedicinalChemistry,2013,vol.67,p.75-80

C53H80N6O18 
  474645-27-7    41833-13-0 

[1]EuropeanJournalofMedicinalChemistry,2013,vol.67,p.75-80

[1]Patent:US2013/323169,2013,A1.Locationinpatent:Paragraph0309;0310

474645-27-7   
C45H44N6O10 
 
C78H106N10O14 

[1]ChemMedChem,2011,vol.6,p.54-59

Literature

Title: Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.

Journal: Analytical chemistry 20120320

Title: Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug.

Journal: Molecular pharmaceutics 20120101

Title: Brentuximab vedotin and crizotinib in anaplastic large-cell lymphoma.

Journal: Cancer journal (Sudbury, Mass.) 20120101

Title: Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer.

Journal: Current opinion in molecular therapeutics 20100401

Title: EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma.

Journal: Journal of the National Cancer Institute 20090902

Title: Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas.

Journal: Blood 20090430

Title: Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

Journal: Nature biotechnology 20080801

Title: Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma.

Journal: British journal of haematology 20080701

Title: Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment.

Journal: Protein engineering, design & selection : PEDS 20060701

Title: Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97.

Journal: Molecular cancer therapeutics 20060601

Title: Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates.

Journal: Cancer research 20060215

Title: Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin E to tumor blood vessels.

Journal: Bioconjugate chemistry 20060101

Title: Efficient elimination of B-lineage lymphomas by anti-CD20-auristatin conjugates.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041201

Title: Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

Title: Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:474645-27-7 Molecular Formula|474645-27-7 MDL|474645-27-7 SMILES|474645-27-7 Monomethyl auristatin e