Title: Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.
Journal: Journal of medicinal chemistry 20161013
Title: Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.
Journal: Neurotoxicology 20151201
Title: Design, synthesis and antitubercular evaluation of novel series of N-[4-(piperazin-1-yl)phenyl]cinnamamide derivatives.
Journal: European journal of medicinal chemistry 20140321
Title: Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom.
Journal: Bioorganic & medicinal chemistry 20130901
Title: Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
Journal: Journal of medicinal chemistry 20130328
Title: Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
Journal: Chemistry & biology 20130321
Title: Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues.
Journal: Bioorganic & medicinal chemistry letters 20121201
Title: Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20121201
Title: Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101
Title: Spectroscopic study of degradation products of ciprofloxacin, norfloxacin and lomefloxacin formed in ozonated wastewater.
Journal: Water research 20121015
Title: Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent.
Journal: Bioorganic & medicinal chemistry letters 20121015
Title: Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.
Journal: Mini reviews in medicinal chemistry 20121001
Title: Improved solvent formulations for efficient CO₂ absorption and low-temperature desorption.
Journal: ChemSusChem 20120901
Title: Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.
Journal: European journal of medicinal chemistry 20120901
Title: Reaction of homopiperazine with endogenous formaldehyde: a carbon hydrogen addition metabolite/product identified in rat urine and blood.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120801
Title: Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
Journal: Journal of medicinal chemistry 20120726
Title: Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120715
Title: Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells.
Journal: Bioorganic & medicinal chemistry letters 20120715
Title: Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120715
Title: Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α₁-adrenoceptor antagonistic properties.
Journal: Bioorganic & medicinal chemistry 20120715
Title: Structural characterization of a novel degradant of the antifungal agent posaconazole.
Journal: Journal of pharmaceutical and biomedical analysis 20120701
Title: Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties.
Journal: Bioorganic & medicinal chemistry letters 20120701
Title: Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120601
Title: Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120601
Title: A Dieckmann cyclization route to piperazine-2,5-diones.
Journal: The Journal of organic chemistry 20120601
Title: Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: modulation by macrocyclic lactone anthelmintics and a receptor for piperazine.
Journal: Veterinary parasitology 20120430
Title: Synthesis and cytotoxic evaluation of some new phthalazinylpiperazine derivatives.
Journal: Archiv der Pharmazie 20120401
Title: Analysis of volatile bases by high performance liquid chromatography with aerosol-based detection.
Journal: Journal of chromatography. A 20120316
Title: Gastroprotective activity and mechanism of novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl)piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration.
Journal: Chemico-biological interactions 20120125
Title: The discovery of potent antagonists of NPBWR1 (GPR7).
Journal: Bioorganic & medicinal chemistry letters 20120115
Title: Prevalence of efflux-mediated ciprofloxacin and levofloxacin resistance in recent clinical isolates of Pseudomonas aeruginosa and its reversal by the efflux pump inhibitors 1-(1-naphthylmethyl)-piperazine and phenylalanine-arginine-β-naphthylamide.
Journal: International journal of antimicrobial agents 20120101
Title: Cyclosulfamide-based derivatives as inhibitors of noroviruses.
Journal: European journal of medicinal chemistry 20120101
Title: New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds.
Journal: European journal of medicinal chemistry 20120101
Title: Synthesis, 5-hydroxytryptamine1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives.
Journal: Chemical & pharmaceutical bulletin 20120101
Title: Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity.
Journal: Bioorganic & medicinal chemistry 20111201
Title: Identification of a new sildenafil analogue in a health supplement.
Journal: Journal of pharmaceutical and biomedical analysis 20111101
Title: Combined 3D-QSAR, molecular docking, and molecular dynamics study on piperazinyl-glutamate-pyridines/pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.
Journal: Journal of chemical information and modeling 20111024
Title: Preparation, spectral and biological investigation of formaldehyde-based ligand containing piperazine moiety and its various polymer metal complexes.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015
Title: Expedient entry to the piperazinohydroisoquinoline ring system using a sequential Ugi/Pictet-Spengler/reductive methylation reaction protocol.
Journal: Chemical communications (Cambridge, England) 20111014
Title: NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells.
Journal: Investigational new drugs 20111001
Title: Discovery of inhibitors of plasminogen activator inhibitor-1: structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives.
Journal: Bioorganic & medicinal chemistry letters 20111001
Title: Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors.
Journal: Organic & biomolecular chemistry 20110907
Title: Intestinal nematode infections in Romania: an epidemiological study and brief review of literature.
Journal: Vector borne and zoonotic diseases (Larchmont, N.Y.) 20110801
Title: Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.
Journal: Biochemistry 20110712
Title: Design, synthesis and biological activity evaluation of arylpiperazine derivatives for the treatment of neuropathic pain.
Journal: Molecules (Basel, Switzerland) 20110707
Title: Discriminating octahedral transition metal ions: highly selective tripodal tris-(2,2'-bipyridine) functionalized piperazine cyclophane receptor for Cu2+ ions.
Journal: Dalton transactions (Cambridge, England : 2003) 20110607
Title: Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator.
Journal: European journal of pharmacology 20110601
Title: Modelling of serotonin reuptake inhibitory and histamine H₃antagonistic activity of piperazine and diazepane amides: QSAR rationales for co-optimization of the activity profiles.
Journal: SAR and QSAR in environmental research 20110601
Title: SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Journal: Bioorganic & medicinal chemistry letters 20110515
Title: Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials.
Journal: Molecules (Basel, Switzerland) 20110505
Title: Discovery of PF-00217830: aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging.
Journal: Bioorganic & medicinal chemistry 20110501
Title: Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Chemical absorption of carbon dioxide with asymmetrically heated polytetrafluoroethylene membranes.
Journal: Journal of environmental management 20110401
Title: Statistically disordered short hydrogen bonds in (pipzH2)(cdoH)2 and a comparison with (pipzH2)(cdo)·H2O (pipz is piperazine and cdoH2 is chelidonic acid).
Journal: Acta crystallographica. Section C, Crystal structure communications 20110401
Title: Modeling CO2 mass transfer in amine mixtures: PZ-AMP and PZ-MDEA.
Journal: Environmental science & technology 20110315
Title: Crystallographic characterisation of Ti(IV) piperazine complexes and their exploitation for the ring opening polymerisation of rac-lactide.
Journal: Dalton transactions (Cambridge, England : 2003) 20110307
Title: II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Journal: Bioorganic & medicinal chemistry 20110301
Title: 9-Piperazine substituted perylene-3,4-dicarboximide as a fluorescent probe in ratiometric analysis.
Journal: Chemical communications (Cambridge, England) 20110227
Title: Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-adrenoreceptor antagonists.
Journal: European journal of medicinal chemistry 20110201
Title: The effects of the 4-(4-Methylpiperazine)phenyl group on nucleosides and oligonucleotides: cellular delivery, detection, and stability.
Journal: Chemistry, an Asian journal 20110201
Title: Studies of tricyclic piperazine/piperidine furnished molecules as novel integrin αvβ3/αIIbβ3 dual antagonists using 3D-QSAR and molecular docking.
Journal: Journal of molecular graphics & modelling 20110201
Title: NMR spectroscopy and surface tension measurements applied to the study of self-association of casopitant mesylate, a novel NK1 antagonist.
Journal: Journal of pharmaceutical and biomedical analysis 20110105
Title: Conformational analysis of piperazine and piperidine analogs of GBR 12909: stochastic approach to evaluating the effects of force fields and solvent.
Journal: Journal of molecular modeling 20110101
Title: β-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS.
Journal: PloS one 20110101
Title: Engineered multifunctional nanotools for biological applications.
Journal: Methods in molecular biology (Clifton, N.J.) 20110101
Title: 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20101001
Title: Patterning of pH sensitive fluorescent bipyridazine derivatives.
Journal: Journal of nanoscience and nanotechnology 20101001
Title: Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands.
Journal: Bioorganic & medicinal chemistry letters 20100915
Title: Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20100915
Title: Validation of an LC-MS method for the detection and quantification of BZP and TFMPP and their hydroxylated metabolites in human plasma and its application to the pharmacokinetic study of TFMPP in humans.
Journal: Journal of forensic sciences 20100901
Title: Bicyclic sigma receptor ligands by stereoselective Dieckmann analogous cyclization of piperazinebutyrate.
Journal: Organic & biomolecular chemistry 20100821
Title: Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
Journal: Bioorganic & medicinal chemistry letters 20100801
Title: Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.
Journal: Bioorganic & medicinal chemistry 20100801
Title: Effects of shape, porosity, and operating parameters on carbon dioxide recovery in polytetrafluoroethylene membranes.
Journal: Journal of hazardous materials 20100715
Title: Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine.
Journal: Bioorganic & medicinal chemistry 20100715
Title: Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines.
Journal: European journal of medicinal chemistry 20100701
Title: Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity.
Journal: Bioorganic & medicinal chemistry letters 20100701
Title: New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.
Journal: Journal of enzyme inhibition and medicinal chemistry 20100601
Title: Three new dioxopiperazine metabolites from a marine-derived fungus Aspergillus fumigatus Fres.
Journal: Natural product research 20100601
Title: Design of new potent and selective secretory phospholipase A(2) inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives.
Journal: Bioorganic & medicinal chemistry 20100515
Title: Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Journal: Bioorganic & medicinal chemistry letters 20100501
Title: Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.
Journal: Bioorganic & medicinal chemistry letters 20100501
Title: A flow-based synthesis of imatinib: the API of Gleevec.
Journal: Chemical communications (Cambridge, England) 20100414
Title: Responsive, di-metallic lanthanide complexes of a piperazine-bridged bis-macrocyclic ligand: modulation of visible luminescence and proton relaxivity.
Journal: Dalton transactions (Cambridge, England : 2003) 20100414
Title: Piperazine bridged resorcinarene cages.
Journal: Organic letters 20100402
Title: Surgical diagnosis and management of intestinal obstruction due to Ascaris lumbricoides.
Journal: Surgical infections 20100401
Title: New discrete and polymeric supramolecular architectures derived from dinuclear Co(II), Ni(II) and Cu(II) complexes of aryl-linked bis-beta-diketonato ligands and nitrogen bases: synthetic, structural and high pressure studies.
Journal: Dalton transactions (Cambridge, England : 2003) 20100321
Title: Evaluation of alkanolamine solutions for carbon dioxide removal in cross-flow rotating packed beds.
Journal: Journal of hazardous materials 20100315
Title: Kinetics of removal of carbon dioxide by aqueous solutions of N,N-diethylethanolamine and piperazine.
Journal: Environmental science & technology 20100315
Title: A comparative study of the efficacy of piperazine and Carica papaya for the control of helminth parasites in village chickens in Zambia.
Journal: Tropical animal health and production 20100301
Title: Molecular modeling studies on the human neuropeptide S receptor and its antagonists.
Journal: ChemMedChem 20100301
Title: Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.
Journal: Bioorganic & medicinal chemistry letters 20100301
Title: Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.
Journal: European journal of medicinal chemistry 20100201
Title: Design and synthesis of piperazine-indole p38 alpha MAP kinase inhibitors with improved pharmacokinetic profiles.
Journal: Bioorganic & medicinal chemistry letters 20100201
Title: Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.
Journal: Journal of medicinal chemistry 20100128
Title: Novel organic proteasome inhibitors identified by virtual and in vitro screening.
Journal: Journal of medicinal chemistry 20100114
Title: Theoretical and experimental studies of the isomeric protonation in solution for a prototype aliphatic ring containing two nitrogens.
Journal: The journal of physical chemistry. B 20100114
Title: Complete experimental and theoretical proton and carbon nuclear magnetic resonance spectral assignments, molecular structure and conformational study of 1-cyclohexylpiperazine and 1-(4-pyridyl)piperazine.
Journal: Magnetic resonance in chemistry : MRC 20100101
Title: Antiplasmodial activity of piperazine sulfonamides.
Journal: Bioorganic & medicinal chemistry letters 20100101
Title: Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.
Journal: Journal of medicinal chemistry 20091210
Title: Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.
Journal: Journal of medicinal chemistry 20091210
Title: Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring.
Journal: ChemMedChem 20091201
Title: The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.
Journal: ChemMedChem 20091201
Title: [Summary of the ICOH 2009 Conference - Cape Town, South Africa].
Journal: Harefuah 20091201
Title: Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice.
Journal: The international journal of neuropsychopharmacology 20091101
Title: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
Journal: Journal of molecular biology 20090904
Title: Quantitative structure activity relationship studies of piperazinyl phenylalanine derivatives as VLA-4/VCAM-1 inhibitors.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20090901
Title: Solvatochromic fluorescence of piperazine-modified bipyridazines for an organic solvent-sensitive film.
Journal: Langmuir : the ACS journal of surfaces and colloids 20090818
Title: LYG-202, a new flavonoid with a piperazine substitution, shows antitumor effects in vivo and in vitro.
Journal: Biochemical and biophysical research communications 20090807
Title: Expedite protocol for construction of chiral regioselectively N-protected monosubstituted piperazine, 1,4-diazepane, and 1,4-diazocane building blocks.
Journal: The Journal of organic chemistry 20090807
Title: Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones.
Journal: European journal of medicinal chemistry 20090801
Title: Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.
Journal: Bioorganic & medicinal chemistry 20090801
Title: 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.
Journal: Bioorganic & medicinal chemistry 20090801
Title: 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.
Journal: Bioorganic & medicinal chemistry 20090715
Title: Retention of ionisable compounds on high-performance liquid chromatography XIX. pH variation in mobile phases containing formic acid, piperazine and tris as buffering systems and methanol as organic modifier.
Journal: Journal of chromatography. A 20090710
Title: Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities.
Journal: European journal of medicinal chemistry 20090701
Title: Interaction of organotin with piperazine derived self-assembled cylindrical bisdithiocarbamates: spectral and thermal investigations.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090701
Title: Synthesis of proline-based diketopiperazine scaffolds.
Journal: The Journal of organic chemistry 20090605
Title: Influence of fluorocarbon flat-membrane hydrophobicity on carbon dioxide recovery.
Journal: Chemosphere 20090601
Title: Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.
Journal: Bioorganic & medicinal chemistry 20090601
Title: Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Journal: Chemistry & biology 20090424
Title: Non-imidazole histamine H3 ligands, part IV: SAR of 1-[2-thiazol-5-yl-(2-aminoethyl)]-4-n-propylpiperazine derivatives.
Journal: European journal of medicinal chemistry 20090401
Title: Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1.
Journal: European journal of medicinal chemistry 20090401
Title: Ghrelin receptor modulators and their therapeutic potential.
Journal: Future medicinal chemistry 20090401
Title: Retention of ionisable compounds on high-performance liquid chromatography XVIII: pH variation in mobile phases containing formic acid, piperazine, tris, boric acid or carbonate as buffering systems and acetonitrile as organic modifier.
Journal: Journal of chromatography. A 20090320
Title: Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20090315
Title: Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20090301
Title: 1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity.
Journal: European journal of medicinal chemistry 20090201
Title: The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.
Journal: European journal of medicinal chemistry 20090201
Title: Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090201
Title: Pleuromutilin derivatives having a purine ring. Part 3: synthesis and antibacterial activity of novel compounds possessing a piperazine ring spacer.
Journal: Bioorganic & medicinal chemistry letters 20090101
Title: Direct zincation of functionalized aromatics and heterocycles by using a magnesium base in the presence of ZnCl2.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20090101
Title: An alternative convenient synthesis of piperidazine-3-carboxylic acid derivatives.
Journal: Chemical & pharmaceutical bulletin 20090101
Title: Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20081215
Title: An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.
Journal: The Journal of organic chemistry 20081107
Title: Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities.
Journal: Organic & biomolecular chemistry 20081107
Title: 6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20081015
Title: Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I).
Journal: Biochemistry 20081007
Title: 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.
Journal: Bioorganic & medicinal chemistry letters 20080901
Title: [Effects of piperazine ferulate on connective tissue growth factor and extracellular matrix in TGF-beta1 induced mesangial cells].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080901
Title: [Effects of piperazine ferulate on TGF-beta1-induced renal interstitial fibroblast activation].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080901
Title: 2,6-Diazaspiro[3.3]heptanes: synthesis and application in Pd-catalyzed aryl amination reactions.
Journal: Organic letters 20080821
Title: Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
Journal: Journal of medicinal chemistry 20080814
Title: Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors.
Journal: European journal of medicinal chemistry 20080801
Title: Model-based analysis for kinetic complexation study of Pizda and Cu(II).
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080801
Title: Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20080715
Title: Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.
Journal: ChemMedChem 20080701
Title: 2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor.
Journal: Bioorganic & medicinal chemistry 20080701
Title: Two-dimensional QSAR studies on arylpiperazines as high-affinity 5-HT(1A) receptor ligands.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701
Title: Practical synthesis of a vanilloid receptor-1 antagonist.
Journal: The Journal of organic chemistry 20080502
Title: Internal pH indicators for biomolecular NMR.
Journal: Journal of biomolecular NMR 20080501
Title: Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines.
Journal: Bioorganic & medicinal chemistry 20080415
Title: Practical experiences with the synthesis of [11C]CH3I through gas phase iodination reaction using a TRACERlabFXC synthesis module.
Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20080401
Title: Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.
Journal: Bioorganic & medicinal chemistry 20080401
Title: Crystal structure and vibrational spectra of piperazinium bis(4-hydroxybenzenesulphonate) molecular-ionic crystal.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201
Title: Isostructural materials achieved by using structurally equivalent donors and acceptors in halogen-bonded cocrystals.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Title: Molecular Pacman: folding, inclusion, and X-ray structures of tri- and tetraamino piperazine cyclophanes.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Title: Piperazine protects the rat heart against sudden cardiac death from barium chloride-induced ventricular fibrillation.
Journal: American journal of therapeutics 20080101
Title: Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
Journal: Bioorganic & medicinal chemistry letters 20071215
Title: Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.
Journal: International journal of antimicrobial agents 20071201
Title: Discovery of 5-HT6 receptor ligands based on virtual HTS.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Atrazine removal by covalent bonding to piperazine functionalized PolyHIPEs.
Journal: The Science of the total environment 20071101
Title: [Study of new blended chemical absorbents to absorb CO2].
Journal: Huan jing ke xue= Huanjing kexue 20071101
Title: Synthesis of bridged piperazines with sigma receptor affinity.
Journal: European journal of medicinal chemistry 20071001
Title: Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position.
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling.
Journal: Bioorganic & medicinal chemistry letters 20070701
Title: DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)].
Journal: Biochemical pharmacology 20070615
Title: Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization.
Journal: Bioorganic & medicinal chemistry letters 20070515
Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.
Journal: Bioorganic & medicinal chemistry 20070515
Title: [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070501
Title: Legal piperazine-containing party pills--a new trend in substance misuse.
Journal: Drug and alcohol review 20070501
Title: Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.
Journal: Bioorganic & medicinal chemistry letters 20070301
Title: Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.
Journal: Journal of pharmaceutical and biomedical analysis 20070219
Title: Analysis of structures with saturated hydrogen bonding.
Journal: Acta crystallographica. Section B, Structural science 20070201
Title: Evaluation of methods for the determination of water in substances with unknown chemical and thermal behaviour.
Journal: Journal of pharmaceutical and biomedical analysis 20070117
Title: Adsorption of Acid Red 73 on copper dithiocarbamate precipitate-type solid wastes.
Journal: Chemosphere 20070101
Title: A case of poly-parasitism involving a trematode and four different nematodes in a migrant from Bihar.
Journal: Indian journal of medical microbiology 20070101
Title: Parallel solution-phase synthesis of 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1lambda6-benzo[1,4]thiazin-3-one derivatives from 1,5-difluoro-2,4-dinitrobenzene.
Journal: Journal of combinatorial chemistry 20070101
Title: Inhibitors of unactivated p38 MAP kinase.
Journal: Bioorganic & medicinal chemistry letters 20061201
Title: Estrogen receptor alpha regulates insulin sensitivity through IRS-1 tyrosine phosphorylation in mature 3T3-L1 adipocytes.
Journal: Endocrine journal 20061201
Title: Two new dioxopiperazine derivatives, arestrictins A and B, isolated from Aspergillus restrictus and Aspergillus penicilloides.
Journal: Chemical & pharmaceutical bulletin 20061201
Title: In vitro anthelmintic activity of Melia azedarach naturalized in Argentina.
Journal: Phytotherapy research : PTR 20061101
Title: Effect of piperazine (diethylenediamine) on the moulting, proteome expression and pyrophosphatase activity of Ascaris suum lung-stage larvae.
Journal: Acta tropica 20061001
Title: Quantitative structure-activity relationship study of new potent and selective antagonists at the 5-HT(1A) and adrenergic alpha(1d) receptors: Derivatives of spiroethyl phenyl(substituted)piperazine.
Journal: Journal of enzyme inhibition and medicinal chemistry 20061001
Title: Propionylpiperazines as human melanocortin-4 receptor ligands.
Journal: Bioorganic & medicinal chemistry letters 20060915
Title: Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.
Journal: Bioorganic & medicinal chemistry letters 20060901
Title: Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams.
Journal: The Journal of organic chemistry 20060901
Title: Comparative study on the regeneration of flue-gas desulfurizing agents by using conventional electrodialysis (ED) and bipolar membrane electrodialysis (BMED).
Journal: Environmental science & technology 20060901
Title: Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury.
Journal: Bioorganic & medicinal chemistry 20060815
Title: Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20060815
Title: Straightforward access to pyrazines, piperazinones, and quinoxalines by reactions of 1,2-diaza-1,3-butadienes with 1,2-diamines under solution, solvent-free, or solid-phase conditions.
Journal: The Journal of organic chemistry 20060804
Title: The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells.
Journal: Cell calcium 20060701
Title: In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.
Journal: Antimicrobial agents and chemotherapy 20060701
Title: Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides.
Journal: Journal of medicinal chemistry 20060615
Title: Axial coordination changes the morphology of porphyrin assemblies in an organogel system.
Journal: Organic & biomolecular chemistry 20060521
Title: Singular value decomposition of torsional angles of analogs of the dopamine reuptake inhibitor GBR 12909.
Journal: Journal of computational chemistry 20060415
Title: Determination of piperazine in pharmaceutical drug substances using capillary electrophoresis with indirect UV detection.
Journal: Journal of chromatography. A 20060331
Title: Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials.
Journal: Bioorganic & medicinal chemistry letters 20060315
Title: Role of excited state intramolecular charge transfer in the photophysical properties of norfloxacin and its derivatives.
Journal: The journal of physical chemistry. A 20060302
Title: Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.
Journal: Bioorganic & medicinal chemistry letters 20060215
Title: Coordination frameworks constructed from bipyridyl piperazine and MCl2 (M = Co, Ni, Zn): structural characterization and optical properties.
Journal: Dalton transactions (Cambridge, England : 2003) 20060214
Title: In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20060201
Title: DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer.
Journal: Bioorganic & medicinal chemistry 20060115
Title: Clinically useful vanilloid receptor TRPV1 antagonists: just around the corner (or too early to tell)?
Journal: Progress in medicinal chemistry 20060101
Title: New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20060101
Title: Synthesis of some n-substituted derivatives of 1-(1h-pyrrole-1 -ylmethyl)- 10-oxa-4-azatricyclo [5.2.1.0(2,6)]dec-8-ene-3,5-dione with an expected anxiolytic activity.
Journal: Acta poloniae pharmaceutica 20060101
Title: Researching the toxicity of party pills.
Journal: Nursing New Zealand (Wellington, N.Z. : 1995) 20051201
Title: Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives.
Journal: Bioorganic & medicinal chemistry letters 20051115
Title: Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20051101
Title: Chiral separation and CD characterisation of enantiomeric cyclotriphosphazene derivatives.
Journal: Chirality 20051001
Title: A facile synthesis of novel herbicidal 1-phenyl-piperazine-2,6-diones.
Journal: Molecules (Basel, Switzerland) 20050930
Title: Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers.
Journal: Bioorganic & medicinal chemistry 20050701
Title: Effect of heterocyclic based organoclays on the properties of polyimide-clay nanocomposites.
Journal: Journal of nanoscience and nanotechnology 20050701
Title: Reciprocal mutations in TM2/TM3 in a D2 dopamine receptor background confirms the importance of this microdomain as a selective determinant of para-halogenated 1,4-disubstituted aromatic piperazines.
Journal: Archiv der Pharmazie 20050601
Title: Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H37Rv.
Journal: Bioorganic & medicinal chemistry letters 20050401
Title: Water soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum.
Journal: Journal of inorganic biochemistry 20050301
Title: Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector.
Journal: Journal of forensic sciences 20050301
Title: Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050201
Title: NMR study on (+/-)-1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050201
Title: IR, MS studies on (+/-)-1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050201
Title: Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines.
Journal: Bioorganic & medicinal chemistry letters 20050201
Title: Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Journal: Bioorganic & medicinal chemistry letters 20050117
Title: Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.
Journal: Bioorganic & medicinal chemistry 20050103
Title: Characterization of inward-rectifier K+ channel inhibition by antiarrhythmic piperazine.
Journal: Biochemistry 20041214
Title: The histamine H4 receptor and potential therapeutic uses for H4 ligands.
Journal: Mini reviews in medicinal chemistry 20041101
Title: Effects of 'Legal X' piperazine analogs on dopamine and serotonin release in rat brain.
Journal: Annals of the New York Academy of Sciences 20041001
Title: Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.
Journal: Journal of medicinal chemistry 20040909
Title: Anti-angiogenic and anti-tumor apoptotic activities of SJ-8002, a new piperazine derivative.
Journal: International journal of oncology 20040801
Title: Effect of temperature on the chromatographic retention of ionizable compounds. I. Methanol-water mobile phases.
Journal: Journal of chromatography. A 20040709
Title: A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.
Journal: The Journal of biological chemistry 20040618
Title: Chiral, nonracemic (piperazin-2-yl)methanol derivatives with sigma-receptor affinity.
Journal: Bioorganic & medicinal chemistry 20040615
Title: Infection with pinworms (Syphacia obvelata) does not affect the plasma corticosterone concentration in male, nonpregnant female, and pregnant female rats.
Journal: Contemporary topics in laboratory animal science 20040501
Title: [Ion-exchange chromatographic behavior and characterization of Staphylococcus aureus in exponential phase].
Journal: Se pu = Chinese journal of chromatography 20040501
Title: New designer drug 1-(3,4-methylenedioxybenzyl) piperazine (MDBP): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry.
Journal: Journal of mass spectrometry : JMS 20040301
Title: The influence of the boat-to-chair conversion on the demetallation of the nickel(II) complex of an open-chain tetramine containing a piperazine fragment.
Journal: Dalton transactions (Cambridge, England : 2003) 20040221
Title: Electrospray mass spectrometry of a series of mixed nitrido 99gTc- heterocomplexes conjugated with bioactive molecules.
Journal: European journal of mass spectrometry (Chichester, England) 20040101
Title: Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.
Journal: Synapse (New York, N.Y.) 20031215
Title: Array synthesis of novel lipodepsipeptide.
Journal: Bioorganic & medicinal chemistry letters 20031201
Title: Massive gastrointestinal bleeding in infants with ascariasis.
Journal: Journal of pediatric surgery 20031101
Title: Formation of p-cresol:piperazine complex in solution monitored by spin-lattice relaxation times and pulsed field gradient NMR diffusion measurements.
Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20031001
Title: An action plan to prevent and combat threadworm infection.
Journal: Nursing times 20031001
Title: Influence of pH on electrophoretic behavior of phenothiazines and determination of pKa values by capillary zone electrophoresis.
Journal: Electrophoresis 20030901
Title: Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-yl] piperazinyl quinolones.
Journal: European journal of medicinal chemistry 20030901
Title: [Antithrombotic effects of morpholine and piperazine ring derivatives and their molecular mechanism].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030901
Title: Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety.
Journal: Behavioural brain research 20030318
Title: Ligand effects on the binding of cis- and trans-[PtCl(2)Am(1)Am(2)] to proteins.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030101
Title: Structure-activity relationship studies: M2 and CCR5 receptor antagonists.
Journal: Current topics in medicinal chemistry 20030101
Title: The formation of paracetamol (acetaminophen) adducts with hydrogen-bond acceptors.
Journal: Acta crystallographica. Section B, Structural science 20021201
Title: A modified synthesis of iodoazidoaryl prazosin.
Journal: The Journal of organic chemistry 20021115
Title: Unusual cerebellar ataxia: 'worm wobble' revisited.
Journal: Archives of disease in childhood 20021001
Title: Natural abundance nitrogen-15 nuclear magnetic resonance spectral studies on selected donors.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20021001
Title: Synthesis and structure-activity relationships of neuromuscular blocking agents.
Journal: Current medicinal chemistry 20020801
Title: A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors.
Journal: Bioorganic & medicinal chemistry letters 20020225
Title: Functional group interactions of a 5-HT3R antagonist.
Journal: BMC biochemistry 20020101
Title: Biliary ascariasis.
Journal: Indian journal of pediatrics 20011201
Title: Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro.
Journal: Experimental eye research 20011101
Title: Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20010903
Title: Significance of ligand tails for interaction with the minor groove of B-DNA.
Journal: Biophysical journal 20010901
Title: Chemistry of the diazeniumdiolates. 2. Kinetics and mechanism of dissociation to nitric oxide in aqueous solution.
Journal: Journal of the American Chemical Society 20010613
