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6972-05-0,MFCD00060474
Catalog No.:AA0036I8

6972-05-0 | N,N-Dimethylthiourea

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1g
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$37.00   $26.00
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5g
95%
in stock  
$72.00   $50.00
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25g
95%
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$251.00   $176.00
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100g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0036I8
Chemical Name:
N,N-Dimethylthiourea
CAS Number:
6972-05-0
Molecular Formula:
C3H8N2S
Molecular Weight:
104.1740
MDL Number:
MFCD00060474
SMILES:
CN(C(=S)N)C
NSC Number:
67246
Properties
Properties
 
BP:
144.6±23.0°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
59.8  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
6  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
-0.2  

Downstream Synthesis Route

[1]Wallach[ChemischeBerichte,1899,vol.32,p.1873]

[2]Kurzer;Sanderson[JournaloftheChemicalSociety,1957,p.4461,4467]

[3]PODREBARAC;NYBERG;FRENCH;CHENG[Journalofmedicinalchemistry,1963,vol.6,p.283-288]

[4]Birkinshaw,TimothyN.;Gillon,DavidW.;Harkin,ShaunA.;Meakins,G.Denis;Tirel,MalkomD.[JournaloftheChemicalSociety.PerkintransactionsI,1984,#2,p.147-153]

[5]Takahashi,Hitoe;Nishina,Atsuyoshi;Fukumoto,Ryo-Hei;Kimura,Hirokazu;Koketsu,Mamoru;Ishihara,Hideharu[LifeSciences,2005,vol.76,#19,p.2185-2192]

[6]CurrentPatentAssignee:ASTELLASPHARMAINC.-US4411900,1983,A

[7]Shimada,Kazuaki;Isogami,Megumi;Maeda,Kitami;Nishinomiya,Rei;Korenaga,Toshinobu[Heterocycles,2020,vol.100,#6,p.881-900]

[1]Schenck;Kirchhof[Hoppe-Seyler'sZeitschriftfurPhysiologischeChemie,1926,vol.153,p.158Anm.][ChemischeBerichte,1927,vol.60,p.2412]

[2]PODREBARAC;NYBERG;FRENCH;CHENG[Journalofmedicinalchemistry,1963,vol.6,p.283-288]

[3]Langenbeck,W.etal.[JustusLiebigsAnnalenderChemie,1965,vol.690,p.42-49]

[4]DeMeglio[Farmaco,EdizioneScientifica,1970,vol.25,#12,p.920-938]

[1]Remers;Roth;Weiss[Journalofmedicinalchemistry,1971,vol.14,#9,p.860-862]Remers,W.A.etal.[JournalofOrganicChemistry,1971,vol.36,p.1232-1240]

[1]JournaloftheChemicalSociety,1964,p.3478-3480

[1]Schroth,Werner;Richter,Monika;Dobner,Bodo;Spitzner,Roland;Freitag,Sabine[MonatsheftefurChemie,1988,vol.119,p.463-476]

[2]Schroth,W.etal.[ZeitschriftfurChemie,1974,vol.14,p.52-53]

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Journal: Pharmacology & toxicology 20030101

Title: Diclofenac induces apoptosis in hepatocytes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030101

Title: Effects of quercetin and quercetin-3-O-glycosides on oxidative damage in rat C6 glioma cells.

Journal: Environmental toxicology and pharmacology 20030101

Title: Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo.

Journal: Glia 20021201

Title: Water stress-induced abscisic acid accumulation triggers the increased generation of reactive oxygen species and up-regulates the activities of antioxidant enzymes in maize leaves.

Journal: Journal of experimental botany 20021201

Title: Outer hair cells functionally and structurally deteriorate during reperfusion.

Journal: Hearing research 20021101

Title: The as-1 promoter element is an oxidative stress-responsive element and salicylic acid activates it via oxidative species.

Journal: Plant physiology 20021101

Title: Reactive oxygen species in sustained airway constriction induced by citric acid aerosol inhalation.

Journal: European journal of pharmacology 20021004

Title: Airway hyperresponsiveness caused by aerosol exposure to residual oil fly ash leachate in mice.

Journal: Journal of toxicology and environmental health. Part A 20020927

Title: Free radicals mediate amphetamine-induced acute pulmonary edema in isolated rat lung.

Journal: Life sciences 20020802

Title: Parenteral iron formulations: a comparative toxicologic analysis and mechanisms of cell injury.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20020701

Title: Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex.

Journal: Free radical biology & medicine 20020615

Title: Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.

Journal: Journal of the American Society of Nephrology : JASN 20020501

Title: Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase.

Journal: Free radical biology & medicine 20020501

Title: Evidence for a circadian rhythm of susceptibility to retinal light damage.

Journal: Photochemistry and photobiology 20020501

Title: Enhancement of reperfusion injury by elevation of microvascular pressures.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species.

Journal: American journal of respiratory cell and molecular biology 20020401

Title: Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide.

Journal: Anesthesiology 20020401

Title: Prevention of the areca nut extract-induced unscheduled DNA synthesis of gingival keratinocytes by vitamin C and thiol compounds.

Journal: Oral oncology 20020401

Title: Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A.

Journal: European journal of clinical investigation 20020301

Title: Hyperpnea-induced production of TBHP-initiated chemiluminescence in guinea pigs.

Journal: Life sciences 20020201

Title: Reactive oxygen species alter gene expression in podocytes: induction of granulocyte macrophage-colony-stimulating factor.

Journal: Journal of the American Society of Nephrology : JASN 20020101

Title: Differential role of reactive oxygen species in chemical hypoxia-induced cell injury in opossum kidney cells and rabbit renal cortical slices.

Journal: Experimental nephrology 20020101

Title: Protection from half-mustard-gas-induced acute lung injury in the rat.

Journal: Journal of applied toxicology : JAT 20020101

Title: Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

Title: Role of reactive oxygen species and glutathione in inorganic mercury-induced injury in human glioma cells.

Journal: Neurochemical research 20011101

Title: Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers.

Journal: Journal of hepatology 20011001

Title: Proteolysis of oxidized proteins after oxygen-glucose deprivation in rat cortical neurons is mediated by the proteasome.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010901

Title: Effect of the hydroxyl radical scavenger, dimethylthiourea, on peripheral nerve tissue perfusion, conduction velocity and nociception in experimental diabetes.

Journal: Diabetologia 20010901

Title: Chemiluminescence in inflammatory bowel disease patients: a parameter of inflammatory activity.

Journal: Clinica chimica acta; international journal of clinical chemistry 20010820

Title: Alleviation of wood smoke-induced lung injury by tachykinin receptor antagonist and hydroxyl radical scavenger in guinea pigs.

Journal: European journal of pharmacology 20010810

Title: The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20010801

Title: Reactive oxygen species mediate angiotensin II-induced leukocyte-endothelial cell interactions in vivo.

Journal: Journal of leukocyte biology 20010801

Title: Enhanced generation of reactive oxygen species in the limb skeletal muscles from a murine infarct model of heart failure.

Journal: Circulation 20010710

Title: Fluxional behavior of the dinitrogen ligand 2,9-dimethyl-1,10-phenanthroline in cationic methyl platinum(II) complexes.

Journal: Inorganic chemistry 20010702

Title: Angiotensin II induces p27(Kip1) expression in renal tubules in vivo: role of reactive oxygen species.

Journal: Journal of molecular medicine (Berlin, Germany) 20010701

Title: Dialysis membrane-induced neutrophil apoptosis is mediated through free radicals.

Journal: Clinical nephrology 20010701

Title: Reactive oxygen species and endotoxic shock: effect of dimethylthiourea.

Journal: Journal of cardiovascular pharmacology and therapeutics 20010701

Title: Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010601

Title: Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals.

Journal: The Journal of laboratory and clinical medicine 20010501

Title: Role of leukocyte accumulation and oxygen radicals in ischemia-reperfusion-induced injury in skeletal muscle.

Journal: American journal of physiology. Heart and circulatory physiology 20010401

Title: H2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation.

Journal: Neurochemical research 20010401

Title: Inhibitory effect of reactive oxygen species on angiotensin I-converting enzyme (kininase II).

Journal: Clinical and experimental pharmacology & physiology 20010301

Title: Does xanthine oxidase contribute to the hydroxyl radical generation in ischemia and reperfusion of the cochlea?

Journal: Hearing research 20010301

Title: Hydrogen peroxide mediates the induction of chloroplastic Ndh complex under photooxidative stress in barley.

Journal: Plant physiology 20010301

Title: DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygen species and specific amino acids.

Journal: Toxicology and applied pharmacology 20010201

Title: Puromycin aminonucleoside induces glomerular epithelial cell apoptosis.

Journal: Experimental and molecular pathology 20010201

Title: Lead-induced hypertension. III. Increased hydroxyl radical production.

Journal: American journal of hypertension 20010201

Title: Antioxidant treatment inhibits activation of myocardial nuclear factor kappa B and inhibits nitrosylation of myocardial heme protein in cardiac transplant rejection.

Journal: Antioxidants & redox signaling 20010201

Title: Oxidant stress activates AP-1 and heparin-binding epidermal growth factor-like growth factor transcription in renal epithelial cells.

Journal: Experimental nephrology 20010101

Title: Detection of dichromate (VI)-induced DNA strand breaks and formation of paramagnetic chromium in multiple mouse organs.

Journal: Toxicology and applied pharmacology 20010101

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Tags:6972-05-0 Molecular Formula|6972-05-0 MDL|6972-05-0 SMILES|6972-05-0 N,N-Dimethylthiourea