Title: Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype.
Journal: Chemico-biological interactions 20180301
Title: Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells.
Journal: Chemico-biological interactions 20151205
Title: Sulfated derivative of 20(S)-ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages.
Journal: Inflammation 20121001
Title: Key role of nuclear factor-κB in the cellular pharmacokinetics of adriamycin in MCF-7/Adr cells: the potential mechanism for synergy with 20(S)-ginsenoside Rh2.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20121001
Title: In vitro studies on the oxidative metabolism of 20(s)-ginsenoside Rh2 in human, monkey, dog, rat, and mouse liver microsomes, and human liver s9.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20121001
Title: Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos.
Journal: Bone 20120601
Title: Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806.
Journal: World journal of microbiology & biotechnology 20120401
Title: Structural modification of ginsenoside Rh(2) by fatty acid esterification and its detoxification property in antitumor.
Journal: Bioorganic & medicinal chemistry letters 20120115
Title: A dynamic study on reversal of multidrug resistance by ginsenoside Rh₂ in adriamycin-resistant human breast cancer MCF-7 cells.
Journal: Talanta 20120115
Title: Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells.
Journal: British journal of pharmacology 20120101
Title: Antihyperglycemic effect of ginsenoside Rh2 by inducing islet β-cell regeneration in mice.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120101
Title: Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics.
Journal: PloS one 20120101
Title: Ginsenoside Rh2(S) induces differentiation and mineralization of MC3T3-E1 cells through activation of the PKD/AMPK signaling pathways.
Journal: International journal of molecular medicine 20111101
Title: Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.
Journal: Molecular carcinogenesis 20111001
Title: Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20111001
Title: [Effects of 20 (S) -ginsenoside Rh2 and 20 (R) -ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cells].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601
Title: Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128.
Journal: Acta pharmacologica Sinica 20110301
Title: Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.
Journal: Cancer letters 20110227
Title: Ginsenoside Rh2 induces Bcl-2 family proteins-mediated apoptosis in vitro and in xenografts in vivo models.
Journal: Journal of cellular biochemistry 20110101
Title: 20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Cholesterol-dependent induction of dendrite formation by ginsenoside Rh2 in cultured melanoma cells.
Journal: International journal of molecular medicine 20101201
Title: Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells.
Journal: Fitoterapia 20101001
Title: Rh2 or its aglycone aPPD in combination with docetaxel for treatment of prostate cancer.
Journal: The Prostate 20100915
Title: Intestinal absorption mechanisms of ginsenoside Rh2: stereoselectivity and involvement of ABC transporters.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100901
Title: Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt.
Journal: British journal of pharmacology 20100701
Title: [Effect of ginsenoside Rh2 on the development of transferred tumors and chemotherapy efficiency].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20100401
Title: Improving enzymatic production of ginsenoside Rh2 from Rg3 by using nonionic surfactant.
Journal: Applied biochemistry and biotechnology 20100201
Title: [Research on the mechanism of ginsenoside Rh2 reversing the resistance of lung adenocarcinoma cells to cisplatin].
Journal: Zhonghua yi xue za zhi 20100126
Title: Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy.
Journal: Cancer chemotherapy and pharmacology 20091101
Title: Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases.
Journal: Pharmaceutical research 20091001
Title: Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice.
Journal: Biological & pharmaceutical bulletin 20091001
Title: Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901
Title: Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption.
Journal: Biochemical and biophysical research communications 20090724
Title: 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity.
Journal: Bioorganic & medicinal chemistry letters 20090615
Title: Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model.
Journal: Planta medica 20090601
Title: Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090401
Title: [Effect of ginsenoside Rh2 on transplanted-tumor and expression of JAM in mice].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901
Title: 20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080401
Title: Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes.
Journal: Neuroscience letters 20080321
Title: 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action.
Journal: British journal of cancer 20080226
Title: Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte.
Journal: Biochemical and biophysical research communications 20071228
Title: Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells.
Journal: Biochemical pharmacology 20071203
Title: Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells.
Journal: Canadian journal of physiology and pharmacology 20071101
Title: Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015
Title: [Effect of ginsenoside Rh2 on immunocompetence of alveolar macrophages in patients with non-small cell lung cancer].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20071001
Title: Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng.
Journal: Journal of microbiology and biotechnology 20070701
Title: Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells.
Journal: Neuroscience letters 20070621
Title: Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20070501
Title: Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells.
Journal: The Journal of pharmacology and experimental therapeutics 20061201
Title: Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatography electrospray ionization mass spectrometry.
Journal: Analytical and bioanalytical chemistry 20061201
Title: Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models.
Journal: Biological & pharmaceutical bulletin 20060901
Title: [Determination of ginsenoside Rd and its metabolites in rat urine by LC-MS].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801
Title: Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells.
Journal: Planta medica 20060601
Title: Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models.
Journal: The Journal of urology 20060501
Title: In vitro assessment of plasma protein binding of 20(R)-ginsenoside Rh2 by equilibrium dialysis and LC-MS analysis: a case of species differences.
Journal: Biological & pharmaceutical bulletin 20060501
Title: 20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons.
Journal: European journal of pharmacology 20060424
Title: Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide.
Journal: Basic & clinical pharmacology & toxicology 20060401
Title: [Determination of 20 (S)-ginsengnoside Rh2 in the alkali-hydrolysis product of saponins from leaves of Panax qinquefolium by RP-HPLC].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060301
Title: Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain.
Journal: European journal of pharmacology 20060113
Title: Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats.
Journal: Clinical and experimental pharmacology & physiology 20060101
Title: Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats.
Journal: Planta medica 20060101
Title: Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells.
Journal: Cancer letters 20051218
Title: Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury.
Journal: Biological & pharmaceutical bulletin 20051001
Title: [Effects of ginsenoside Rh2(GS-Rh2) on cell cycle of Eca-109 esophageal carcinoma cell line].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001
Title: High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425
Title: Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells.
Journal: Biological & pharmaceutical bulletin 20050201
Title: Liquid chromatography/tandem mass spectrometry for pharmacokinetic studies of 20(R)-ginsenoside Rg3 in dog.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs.
Journal: European journal of drug metabolism and pharmacokinetics 20050101
Title: Liquid chromatography/mass spectrometric analysis of rat samples for in vivo metabolism and pharmacokinetic studies of ginsenoside Rh2.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: [Effect of telomerase on ginsenoside Rh2-induced differentiation of hepatocarcinoma cell line SMMC-7721].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20041201
Title: [Effects of ginsenoside Rh2 on signal transduction in hepatocarcinoma SMMC-7721 cells].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20040901
Title: [Induction of differentiation by ginsenoside Rh2 in hepatocarcinoma cell SMMC-7721].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20040801
Title: Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and -3 and up-regulation of Bax in human neuroblastoma.
Journal: Archives of pharmacal research 20040801
Title: Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy.
Journal: Canadian journal of physiology and pharmacology 20040701
Title: Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells.
Journal: Archives of pharmacal research 20040401
Title: Ginsenoside Rh2 reduces ischemic brain injury in rats.
Journal: Biological & pharmaceutical bulletin 20040301
Title: Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2.
Journal: Canadian journal of physiology and pharmacology 20040301
Title: Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants.
Journal: Archives of pharmacal research 20040101
Title: Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells.
Journal: Journal of biochemical and molecular toxicology 20040101
Title: The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis.
Journal: The Journal of biological chemistry 20031212
Title: In vitro induction of differentiation by ginsenoside Rh2 in SMMC-7721 hepatocarcinoma cell line.
Journal: Pharmacology & toxicology 20031201
Title: Antiallergic activity of ginsenoside Rh2.
Journal: Biological & pharmaceutical bulletin 20031101
Title: SEK1-dependent JNK1 activation prolongs cell survival during G-Rh2-induced apoptosis.
Journal: Biochemical and biophysical research communications 20030502
Title: Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells.
Journal: Acta pharmacologica Sinica 20020401
Title: [Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020301
Title: Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh(2).
Journal: Japanese journal of cancer research : Gann 20011101
Title: The antimetastatic and immunomodulating activities of ginseng minor glycosides.
Journal: Doklady. Biochemistry and biophysics 20010101
Title: Ginsenoside RH-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway.
Journal: Life sciences 19990101
Title: Guo XX, et al. p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. Protein Cell. 2014 Mar;5(3):224-34.
Title: Wang M, et al. Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model. Oncol Lett. 2017 Feb;13(2):681-685.
