Home Other Building Blocks 5625-67-2
5625-67-2,MFCD01318687
Catalog No.:AA003HTE

5625-67-2 | Piperazin-2-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$7.00   $5.00
- +
10g
95%
in stock  
$9.00   $7.00
- +
25g
95%
in stock  
$20.00   $14.00
- +
100g
95%
in stock  
$56.00   $39.00
- +
500g
98%
in stock  
$265.00   $185.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003HTE
Chemical Name:
Piperazin-2-one
CAS Number:
5625-67-2
Molecular Formula:
C4H8N2O
Molecular Weight:
100.1191
MDL Number:
MFCD01318687
SMILES:
O=C1CNCCN1
NSC Number:
27441
Properties
Properties
 
BP:
307.1°C at 760 mmHg  
Form:
Solid  
MP:
132-135°C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
81.8  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
-1.1  

Upstream Synthesis Route

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[2]Patent:WO2006/63113,2006,A2,.Locationinpatent:Page/Pagecolumn126-127

[3]Patent:US2787617,1955,,

[1]Patent:US2005/222166,2005,A1,.Locationinpatent:Page/Pagecolumn13

[2]TetrahedronLetters,1994,vol.35,#51,p.9545-9548

[3]Patent:WO2006/51851,2006,A1,.Locationinpatent:Page/Pagecolumn80

[4]JournaloftheAmericanChemicalSociety,1940,vol.62,p.1202

[1]JournalofPorphyrinsandPhthalocyanines,2010,vol.14,#3,p.284-292

[2]TetrahedronLetters,2017,vol.58,#51,p.4750-4754

[1]Patent:CN104277040,2016,B,.Locationinpatent:Paragraph0159-0160

[2]AngewandteChemie,InternationalEdition,2015,vol.54,#1,p.179-183

[3]AngewandteChemie,2015,vol.127,#1,p.181-185,5

[1]Patent:WO2004/63150,2004,A2,.Locationinpatent:Page27-28

Downstream Synthesis Route

[1]Patent:WO2006/55951,2006,A2.Locationinpatent:Page/Pagecolumn66

[2]Patent:WO2006/63113,2006,A2.Locationinpatent:Page/Pagecolumn126-127

[3]Patent:US2787617,1955,

[1]JournalofMedicinalChemistry,1970,vol.13,p.846-848

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[3]EuropeanJournalofMedicinalChemistry,2015,vol.101,p.218-235

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[7]ChemicalCommunications,2019,vol.55,p.14351-14354

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[9]Patent:WO2005/14540,2005,A1.Locationinpatent:Page/Pagecolumn59

[10]Patent:WO2006/14762,2006,A1.Locationinpatent:Page/Pagecolumn37

[11]Patent:WO2006/14944,2006,A1.Locationinpatent:Page/Pagecolumn29

[12]Patent:US2018/127370,2018,A1.Locationinpatent:Paragraph0735;0733

[13]Patent:WO2005/16876,2005,A2.Locationinpatent:Page/Pagecolumn75-76

[14]Patent:EP1591443,2005,A1.Locationinpatent:Page/Pagecolumn63

[15]Patent:US6235731,2001,B1

[16]Patent:EP1621537,2006,A1.Locationinpatent:Page/Pagecolumn47;51-52

[17]Patent:EP1762568,2007,A1.Locationinpatent:Page/Pagecolumn36-37;57

[18]Patent:EP1785418,2007,A1.Locationinpatent:Page/Pagecolumn43;72

[19]Patent:EP1803719,2007,A1.Locationinpatent:Page/Pagecolumn39

[20]Patent:CN107098886,2017,A.Locationinpatent:Paragraph0147-0149

[21]Patent:EP1477490,2004,A1.Locationinpatent:Page109

[22]Patent:WO2017/117393,2017,A1.Locationinpatent:Page/Pagecolumn148

[23]Patent:WO2016/168619,2016,A1.Locationinpatent:Paragraph00291

[24]TetrahedronLetters,1980,vol.21,p.3019-3020

[25]Patent:WO2004/35576,2004,A2.Locationinpatent:Page172;173

[26]Patent:US2003/109559,2003,A1

[27]Patent:US6403595,2002,B1

[28]Patent:US5629322,1997,A

[29]Patent:US4341698,1982,A

[30]BioorganicandMedicinalChemistryLetters,2008,vol.18,p.3236-3241

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[32]Patent:WO2013/134226,2013,A1.Locationinpatent:Page/Pagecolumn94

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[34]Patent:WO2014/100716,2014,A1.Locationinpatent:Paragraph00222

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[39]Patent:CN109867660,2019,A.Locationinpatent:Paragraph0383-0384

[1]Arzneimittel-Forschung/DrugResearch,1986,vol.36,p.1545-1549

[1]JournalofMedicinalChemistry,1980,vol.23,p.1358-1363

[2]Patent:US4448962,1984,A

Literature

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Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Identification of novel sildenafil-analogues in an adulterated herbal food supplement.

Journal: Journal of pharmaceutical and biomedical analysis 20111205

Title: Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists.

Journal: Journal of medicinal chemistry 20111027

Title: Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: A submarine journey: the pyrrole-imidazole alkaloids.

Journal: Marine drugs 20091201

Title: Ligand scaffold hopping combining 3D maximal substructure search and molecular similarity.

Journal: BMC bioinformatics 20090101

Title: Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines.

Journal: Journal of asthma and allergy 20090101

Title: Computer applications for prediction of protein-protein interactions and rational drug design.

Journal: Advances and applications in bioinformatics and chemistry : AABC 20090101

Title: Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.

Journal: Journal of medicinal chemistry 20081009

Title: Concise synthesis of the CDE ring system of tetrahydroisoquinoline alkaloids using carbophilic Lewis acid-catalyzed hydroamidation and oxidative Friedel-Crafts cyclization.

Journal: The Journal of organic chemistry 20080704

Title: Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080601

Title: Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers.

Journal: Bioorganic & medicinal chemistry 20080201

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Journal: Die Pharmazie 20061001

Title: New class of nucleophiles for palladium-catalyzed asymmetric allylic alkylation. Total synthesis of agelastatin A.

Journal: Journal of the American Chemical Society 20060510

Title: Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.

Journal: Organic & biomolecular chemistry 20060507

Title: (13)C NMR spectral assignment of 1,4-diarylpiperazinones.

Journal: Magnetic resonance in chemistry : MRC 20060101

Title: Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors III. Effect of ring opening of piperazinone moiety on inhibition.

Journal: Chemical & pharmaceutical bulletin 20040401

Title: Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

Journal: Bioorganic & medicinal chemistry letters 20040209

Title: Synthesis of a library of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives and identification of bioactive compounds.

Journal: Journal of combinatorial chemistry 20040101

Title: alpha-Keto amides as precursors to heterocycles--generation and cycloaddition reactions of piperazin-5-one nitrones.

Journal: Organic & biomolecular chemistry 20030407

Title: Synthesis of 1,4-diazines by ring expansion of 1,3-diazines.

Journal: The Journal of organic chemistry 20030321

Title: Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.

Journal: Journal of medicinal chemistry 20030227

Title: Potent dibasic GPIIb/IIIa antagonists with reduced prolongation of bleeding time: synthesis and pharmacological evaluation of 2-oxopiperazine derivatives.

Journal: Journal of medicinal chemistry 20010719

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