Home Amines 5440-00-6
5440-00-6,MFCD00006551
Catalog No.:AA003M6O

5440-00-6 | 5,6-Diamino-1,3-dimethylpyrimidine-2,4(1h,3h)-dione

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250mg
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1g
98%
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$86.00   $61.00
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5g
technical grade
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$225.00   $158.00
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25g
technical grade
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003M6O
Chemical Name:
5,6-Diamino-1,3-dimethylpyrimidine-2,4(1h,3h)-dione
CAS Number:
5440-00-6
Molecular Formula:
C6H10N4O2
Molecular Weight:
170.1692
MDL Number:
MFCD00006551
SMILES:
Nc1n(C)c(=O)n(c(=O)c1N)C
NSC Number:
15493
Properties
Properties
 
BP:
243.6°C at 760 mmHg  
Form:
Solid  
MP:
210-214 °C (dec.)(lit.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
283  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
XLogP3:
-0.5  

Downstream Synthesis Route

[1]Yang,Shyh-Ming;Yasgar,Adam;Miller,Bettina;Lal-Nag,Madhu;Brimacombe,Kyle;Hu,Xin;Sun,Hongmao;Wang,Amy;Xu,Xin;Nguyen,Kimloan;Oppermann,Udo;Ferrer,Marc;Vasiliou,Vasilis;Simeonov,Anton;Jadhav,Ajit;Maloney,DavidJ.[JournalofMedicinalChemistry,2015,vol.58,#15,p.5967-5978]

[2]CurrentPatentAssignee:HYDRABIOSCIENCES,INC-US2014/275528,2014,A1Locationinpatent:Paragraph0276;0277

[3]CurrentPatentAssignee:UNIVERSITYOFCOLORADO(SYSTEM);GOVERNMENTOFTHEUNITEDSTATES-WO2016/86008,2016,A1Locationinpatent:Paragraph0242-0243

[4]CurrentPatentAssignee:Bayer&Co.-DE213711,1800,C[Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.9,p.1010][Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.9,p.1010]

[1]ChemickeZvesti,1958,vol.12,p.519,521    Chem.Abstr.,1959,p.3232

5440-00-6    20615-64-9   
8-fluoren-9-yl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 

[1]JournaloftheAmericanPharmaceuticalAssociation(1912),1954,vol.43,p.152,154

[1]CurrentPatentAssignee:SHAOXINGKINGYEARBIOCHEMICAL-CN110204547,2019,ALocationinpatent:Paragraph0025;0027;0030-0032

[2]Traube,W.[ChemischeBerichte,1900,vol.33,p.3047][ChemischesZentralblatt,1901,vol.72,#I,p.548]

[1]CurrentPatentAssignee:LIFE&BRAINGMBH-WO2012/76974,2012,A1Locationinpatent:Page/Pagecolumn27;30

[2]CurrentPatentAssignee:CSPCPHARMACEUTICALGROUPLIMITED-CN104003941,2016,BLocationinpatent:Paragraph0021;0022

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2004/74288,2004,A1Locationinpatent:Page43-44

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[5]Blicke;Godt[JournaloftheAmericanChemicalSociety,1954,vol.76,p.2798]

[6]Hueso-Urena,Francisco;Moreno-Carretero,MiguelN.;Low,JohnN.;Masterton,AlisonG.[JournalofMolecularStructure,1997,vol.435,#2,p.133-141]

[7]Shirsagar;Bhave[JournaloftheIndianChemicalSociety,1997,vol.74,#8,p.649-651]

[8]Baraldi,PierGiovanni;Tabrizi,MojganAghazadeh;Preti,Delia;Bovero,Andrea;Romagnoli,Romeo;Fruttarolo,Francesca;Zaid,NaserAbdel;Moorman,AllanR.;Varani,Katia;Gessi,Stefania;Merighi,Stefania;Borea,PierAndrea[JournalofMedicinalChemistry,2004,vol.47,#6,p.1434-1447]

[9]Kalla,RaoV.;Elzein,Elfatih;Perry,Thao;Li,Xiaofen;Palle,Venkata;Varkhedkar,Vaibhav;Gimbel,Arthur;Maa,Tennig;Zeng,Dewan;Zablocki,Jeff[JournalofMedicinalChemistry,2006,vol.49,#12,p.3682-3692]

[10]CurrentPatentAssignee:UCB-WO2007/65595,2007,A2Locationinpatent:Page/Pagecolumn24

[11]Locationinpatent:bodytextBansal,Ranju;Kumar,Gulshan;Gandhi,Deepika;Young,LouiseC.;Harvey,AlanL.[EuropeanJournalofMedicinalChemistry,2009,vol.44,#5,p.2122-2127]

[12]Locationinpatent:bodytextBansal,Ranju;Kumar,Gulshan;Gandhi,Deepika;Yadav,Rakesh;Young,LouiseC.;Harvey,AlanL.[Arzneimittel-Forschung/DrugResearch,2010,vol.60,#3,p.131-136]

[13]Locationinpatent:experimentalpartHu,Suwen;Nian,Siyun;Qin,Kuiyou;Xiao,Tong;Li,Ngna;Qi,Xiaolu;Ye,Faqing;Liang,Guang;Hu,Guoxin;He,Jincai;Yu,Yinfei;Song,Bo[ChemicalandPharmaceuticalBulletin,2012,vol.60,#3,p.385-390]

[14]Hayallah,AlaaM.;Talhouni,AhmadA.;AbdelAlim,AbdelAlimM.[ArchivesofPharmacalResearch,2012,vol.35,#8,p.1355-1368]

[15]Bansal,Ranju;Kumar,Gulshan;Rohilla,Suman;Klotz,Karl-Norbert;Kachler,Sonja;Young,LouiseC.;Harvey,AlanL.[DrugDevelopmentResearch,2016,p.241-250]

[16]CurrentPatentAssignee:SHANGHAIBETTERINPHARMACEUTICALTECH-CN106046004,2016,ALocationinpatent:Paragraph0071;0072;0073;0074;0075;0076

[17]CurrentPatentAssignee:ChenHongfang;ChenDeru;ZhangYan;HuKaijun;ChenXiangli-CN107987028,2018,ALocationinpatent:Paragraph0024

[18]Hisham,Mohamed;Youssif,BahaaG.M.;Osman,EssamEldinA.;Hayallah,AlaaM.;Abdel-Aziz,Mohamed[EuropeanJournalofMedicinalChemistry,2019,vol.176,p.117-128]Abou-Zied,HeshamA.;Youssif,BahaaG.M.;Mohamed,MamdouhF.A.;Hayallah,AlaaM.;Abdel-Aziz,Mohamed[BioorganicChemistry,2019,vol.89]

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[20]CurrentPatentAssignee:GUANGDONGUNIVERSITYOFTECHNOLOGY-CN111072574,2020,ALocationinpatent:Paragraph0044;0047

[21]CurrentPatentAssignee:SHIJIAZHUANGPHARMACEUTICALGROUPNEWNORWICHPHAR-CN112047947,2020,ALocationinpatent:Paragraph0049-0050

Literature

Title: New 2,6-bis-[uracil-imino] ethylpyridine complexes containing the CdN(6) core: Synthesis, crystal structures, luminescent properties and antiproliferative activity against C6 glioma cells.

Journal: Journal of inorganic biochemistry 20090801

Title: Synthesis, characterization and antiproliferative activity of metal complexes with the Schiff base derived from the condensation 1:2 of 2,6-diformyl-4-methylphenol and 5,6-diamino-1,3-dimethyluracil.

Journal: Journal of inorganic biochemistry 20080401

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Tags:5440-00-6 Molecular Formula|5440-00-6 MDL|5440-00-6 SMILES|5440-00-6 5,6-Diamino-1,3-dimethylpyrimidine-2,4(1h,3h)-dione |Heterocyclic_Building_Blocks