Catalog No.:AA003N5M

53188-07-1 | 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

Name: Name:6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Brand: AABLOCKS
SKU: AA003N5M
Availability: InStock
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1mg

95%

in stock

$6.00 $4.00

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250mg

95%

in stock

$27.00 $19.00

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95%

in stock

$43.00 $30.00

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95%

in stock

$65.00 $46.00

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10g

97%

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$120.00 $84.00

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25g

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$261.00 $183.00

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100g

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$916.00 $641.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
Application
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA003N5M

Chemical Name:

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

CAS Number:

53188-07-1

Molecular Formula:

C14H18O4

Molecular Weight:

250.2903

MDL Number:

MFCD00006846

SMILES:

Cc1c2OC(C)(CCc2c(c(c1C)O)C)C(=O)O

Properties

BP:

450.3°C at 760 mmHg

Form:

Solid

MP:

187-189 °C(lit.);

Refractive Index:

1.4970 (estimate)

Storage:

Keep in dry area;Room Temperature;

Computed Properties

Complexity:

343

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

XLogP3:

2.8

Downstream Synthesis Route

15837-47-5

53188-07-1

6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylicacid(6-amino-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

[1]Isobe,Yoshiaki;Tobe,Masanori;Inoue,Yoshifumi;Isobe,Masakazu;Tsuchiya,Masami;Hayashi,Hideya[BioorganicandMedicinalChemistry,2003,vol.11,#23,p.4933-4940]

36653-82-4

53188-07-1

(±)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylicacidhexadecylester

[1]CurrentPatentAssignee:SINOBIOPHARMACEUTICALLIMITED-EP2799438,2014,A1Locationinpatent:Paragraph0099-0101

[2]CurrentPatentAssignee:SINOBIOPHARMACEUTICALLIMITED-US2014/343088,2014,A1Locationinpatent:Paragraph0195;0197;0198;0199

[3]Zhang,Xiquan;Cao,Meng;Xing,Jing;Liu,Fei;Dong,Ping;Tian,Xin;Xu,Hongjiang;Zhang,Laifang;Gu,Hongmei;Yang,Ling;Li,Rui;Zheng,Ming;Ji,Min;Gu,Ning[MedicinalChemistryResearch,2017,vol.26,#12,p.3395-3406]

58186-27-9

56305-04-5

3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylicacid10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decylester

[1]Molecules,2017,vol.22

343778-59-6

53188-07-1

N-(1-(3-chlorobenzyl)piperidin-4-yl)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxamide

[1]Cai,Pei;Fang,Si-Qiang;Yang,Xue-Lian;Wu,Jia-Jia;Liu,Qiao-Hong;Hong,Hao;Wang,Xiao-Bing;Kong,Ling-Yi[ACSChemicalNeuroscience,2017,vol.8,#11,p.2496-2511]

138-14-7

53188-07-1

N1-hydroxy-N-(5-(4-(hydroxy(1-(6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxamido)-1λ5,5λ3-pentyl)amino)-4-oxobutanamido)pentyl)-N4-(5-(N-hydroxyacetamido)pentyl)succinamide

[1]CurrentPatentAssignee:UNIVERSITYOFSYDNEY-WO2017/201581,2017,A1Locationinpatent:Page/Pagecolumn31;32

Literature

Title: Mickle DA, et al. Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction. Ann Thorac Surg. 1989 Apr;47(4):553-7.

Title: Forrest VJ, et al. Oxidative stress-induced apoptosis prevented by Trolox. Free Radic Biol Med. 1994 Jun;16(6):675-84.

Title: Wu TW, et al. The cytoprotective effect of Trolox demonstrated with three types of human cells. Biochem Cell Biol. 1990 Oct;68(10):1189-94.

Application

(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, commonly known as Trolox, serves as a crucial compound in antioxidant assays. Specifically, it is utilized in the 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid equivalent antioxidant assay (TEAC) to evaluate the total antioxidant capacity of various fruit species. Trolox's presence in TEAC facilitates the measurement of the antioxidant activity of fruits by comparing their effects with the antioxidant properties of Trolox. This compound plays a pivotal role in assessing and understanding the antioxidant capabilities of different fruits, aiding in nutritional and pharmaceutical research endeavors.

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SDS