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65391-42-6,MFCD00058004
Catalog No.:AA003O32

65391-42-6 | Bestatin Hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $6.00
- +
10mg
98%
in stock  
$26.00   $18.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003O32
Chemical Name:
Bestatin Hydrochloride
CAS Number:
65391-42-6
Molecular Formula:
C16H25ClN2O4
Molecular Weight:
344.8337
MDL Number:
MFCD00058004
SMILES:
O[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)[C@@H](Cc1ccccc1)N.Cl
Properties
Properties
 
BP:
544.8°C at 760 mmHg  
Form:
Solid  
MP:
216-218 °C  
Solubility:
H2O: 25 mg/mL, clear, colorless  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
367  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Upstream Synthesis Route

[1]Bioscience,BiotechnologyandBiochemistry,1999,vol.63,#7,p.1304-1307

[2]OrganicLetters,2000,vol.2,#26,p.4245-4247

[1]Tetrahedron,2003,vol.59,#35,p.6771-6784

[1]JournalofOrganicChemistry,2004,vol.69,#8,p.2844-2850

[1]JournalofOrganicChemistry,2004,vol.69,#8,p.2844-2850

[2]TetrahedronLetters,2003,vol.44,#48,p.8685-8687

[1]JournalofOrganicChemistry,2004,vol.69,#8,p.2844-2850

[2]TetrahedronLetters,2003,vol.44,#48,p.8685-8687

Downstream Synthesis Route

[1]Bioscience,BiotechnologyandBiochemistry,1999,vol.63,p.1304-1307

Literature

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

Journal: Journal of medicinal chemistry 20071129

Title: Hossain A, et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6

Title: Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23(3):e680-9.

Title: Lis M, et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35(1):133-8

Title: Poloz Y, et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11(4):545-57

Quotation Request
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SDS
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Tags:65391-42-6 Molecular Formula|65391-42-6 MDL|65391-42-6 SMILES|65391-42-6 Bestatin Hydrochloride
Catalog No.: AA003O32
65391-42-6,MFCD00058004
65391-42-6 | Bestatin Hydrochloride
Pack Size： 1mg
Purity： 98%
in stock
$8.00 $6.00
Pack Size： 10mg
Purity： 98%
in stock
$26.00 $18.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003O32
Chemical Name: Bestatin Hydrochloride
CAS Number: 65391-42-6
Molecular Formula: C16H25ClN2O4
Molecular Weight: 344.8337
MDL Number: MFCD00058004
SMILES: O[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)[C@@H](Cc1ccccc1)N.Cl
Properties
BP: 544.8°C at 760 mmHg  
Form: Solid  
MP: 216-218 °C  
Solubility: H2O: 25 mg/mL, clear, colorless  
Storage: Inert atmosphere;-20 ℃;  
Complexity: 367  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Upstream Synthesis Route
60016-66-2    65391-42-6 

[1]Bioscience,BiotechnologyandBiochemistry,1999,vol.63,#7,p.1304-1307

[2]OrganicLetters,2000,vol.2,#26,p.4245-4247

246506-78-5    65391-42-6 

[1]Tetrahedron,2003,vol.59,#35,p.6771-6784

65322-89-6    65391-42-6 

[1]JournalofOrganicChemistry,2004,vol.69,#8,p.2844-2850

6125-24-2    65391-42-6 

[1]JournalofOrganicChemistry,2004,vol.69,#8,p.2844-2850

[2]TetrahedronLetters,2003,vol.44,#48,p.8685-8687

640279-63-6    65391-42-6 

[1]JournalofOrganicChemistry,2004,vol.69,#8,p.2844-2850

[2]TetrahedronLetters,2003,vol.44,#48,p.8685-8687

Downstream Synthesis Route
59969-65-2    65391-42-6 

[1]Bioscience,BiotechnologyandBiochemistry,1999,vol.63,p.1304-1307

Literature fold

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

Journal: Journal of medicinal chemistry20071129

Title: Hossain A, et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6

Title: Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23(3):e680-9.

Title: Lis M, et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35(1):133-8

Title: Poloz Y, et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11(4):545-57

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