Home Other Building Blocks 4674-50-4
4674-50-4,MFCD04974578
Catalog No.:AA003T7K

4674-50-4 | Nootkatone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
100mg
95%
in stock  
$18.00   $13.00
- +
1g
95%
in stock  
$39.00   $27.00
- +
5g
98%
in stock  
$136.00   $96.00
- +
25g
97%
in stock  
$643.00   $450.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003T7K
Chemical Name:
Nootkatone
CAS Number:
4674-50-4
Molecular Formula:
C15H22O
Molecular Weight:
218.3346
MDL Number:
MFCD04974578
SMILES:
O=C1C[C@@H](C)[C@]2(C(=C1)CC[C@H](C2)C(=C)C)C
FEMA Number:
3166
Properties
Properties
 
BP:
318.6°C at 760 mmHg  
Form:
Solid  
MP:
35-39 °C  
Refractive Index:
n20/D 1.52  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
364  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.9  

Literature

Title: HPTLC and reverse phase HPLC methods for the simultaneous quantification and in vitro screening of antioxidant potential of isolated sesquiterpenoids from the rhizomes of Cyperus rotundus.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Efficacy and environmental persistence of nootkatone for the control of the blacklegged tick (Acari: Ixodidae) in residential landscapes.

Journal: Journal of medical entomology 20120901

Title: CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase.

Journal: Applied microbiology and biotechnology 20120701

Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal: Journal of medicinal chemistry 20120524

Title: Functional expression of a valencene dioxygenase from Pleurotus sapidus in E. coli.

Journal: Bioresource technology 20120301

Title: Efficacy of plant-derived and synthetic compounds on clothing as repellents against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae).

Journal: Journal of medical entomology 20120101

Title: A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--Part 27.

Journal: British journal of sports medicine 20111201

Title: Experimental use of two standard tick collection methods to evaluate the relative effectiveness of several plant-derived and synthetic repellents against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae).

Journal: Journal of economic entomology 20111201

Title: A formulation to encapsulate nootkatone for tick control.

Journal: Journal of medical entomology 20111101

Title: (+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction.

Journal: Journal of ethnopharmacology 20111011

Title: Toxic effects of Citrus aurantium and C. limon essential oils on Spodoptera frugiperda (Lepidoptera: Noctuidae).

Journal: Natural product communications 20110901

Title: Determination of volatile, phenolic, organic acid and sugar components in a Turkish cv. Dortyol (Citrus sinensis L. Osbeck) orange juice.

Journal: Journal of the science of food and agriculture 20110815

Title: Biologically important eremophilane sesquiterpenes from alaska cedar heartwood essential oil and their semi-synthetic derivatives.

Journal: Molecules (Basel, Switzerland) 20110608

Title: Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone.

Journal: Journal of ethnopharmacology 20110426

Title: Microbial transformation of (+)-nootkatone and the antiproliferative activity of its metabolites.

Journal: Bioorganic & medicinal chemistry 20110401

Title: Suppression of host-seeking Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) nymphs after dual applications of plant-derived acaricides in New Jersey.

Journal: Journal of economic entomology 20110401

Title: Susceptibility of four tick species, Amblyomma americanum, Dermacentor variabilis, Ixodes scapularis, and Rhipicephalus sanguineus (Acari: Ixodidae), to nootkatone from essential oil of grapefruit.

Journal: Journal of medical entomology 20110301

Title: The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket.

Journal: Biochemistry 20110208

Title: Anti-allergic activity of sesquiterpenes from the rhizomes of Cyperus rotundus.

Journal: Archives of pharmacal research 20110201

Title: A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene.

Journal: FEBS letters 20110103

Title: The use of endophytes to obtain bioactive compounds and their application in biotransformation process.

Journal: Biotechnology research international 20110101

Title: Plant-based insect repellents: a review of their efficacy, development and testing.

Journal: Malaria journal 20110101

Title: Comparative analysis of the volatile fraction of fruit juice from different Citrus species.

Journal: PloS one 20110101

Title: [Study on quality standards of decoction pieces of salt Alpinia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

Title: Mode of action for natural products isolated from essential oils of two trees is different from available mosquito adulticides.

Journal: Journal of medical entomology 20101101

Title: Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.

Journal: American journal of physiology. Endocrinology and metabolism 20100801

Title: Structural requirements for repellency: norsesquiterpenes and sesquiterpenoid derivatives of nootkatone against the Formosan subterranean termite (Isoptera: Rhinotermitidae).

Journal: Pest management science 20100801

Title: Natural toxins for use in pest management.

Journal: Toxins 20100801

Title: Catalytic oxidation of concentrated orange oil phase by synthetic metallic complexes biomimetic to MMO enzyme.

Journal: Journal of the science of food and agriculture 20100701

Title: Ability of two natural products, nootkatone and carvacrol, to suppress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme disease endemic area of New Jersey.

Journal: Journal of economic entomology 20091201

Title: Genome mining in Sorangium cellulosum So ce56: identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450.

Journal: The Journal of biological chemistry 20091016

Title: An efficient and economic asymmetric synthesis of (+)-nootkatone, tetrahydronootkatone, and derivatives.

Journal: Organic letters 20090820

Title: Nootkatone--a biotechnological challenge.

Journal: Applied microbiology and biotechnology 20090501

Title: Regioselective biooxidation of (+)-valencene by recombinant E. coli expressing CYP109B1 from Bacillus subtilis in a two-liquid-phase system.

Journal: Microbial cell factories 20090101

Title: Toxicity, tunneling and feeding behavior of the termite, Coptotermes vastator, in sand treated with oil of the physic nut, Jatropha curcas.

Journal: Journal of insect science (Online) 20090101

Title: Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Journal: Chemical research in toxicology 20080401

Title: Citrus genomics.

Journal: International journal of plant genomics 20080101

Title: Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid.

Journal: BMC biotechnology 20080101

Title: [GC-MS analysis of volatile constituents from five different kinds of Chinese eaglewood].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070501

Title: Repellent activity of fractioned compounds from Chamaecyparis nootkatensis essential oil against nymphal Ixodes scapularis (Acari: Ixodidae).

Journal: Journal of medical entomology 20060901

Title: Volatile constituents of redblush grapefruit (Citrus paradisi) and pummelo (Citrus grandis) peel essential oils from Kenya.

Journal: Journal of agricultural and food chemistry 20051214

Title: Biotransformation of citrus aromatics nootkatone and valencene by microorganisms.

Journal: Chemical & pharmaceutical bulletin 20051101

Title: Highly efficient production of nootkatone, the grapefruit aroma from valencene, by biotransformation.

Journal: Chemical & pharmaceutical bulletin 20051101

Title: Changes in heartwood chemistry of dead yellow-cedar trees that remain standing for 80 years or more in southeast Alaska.

Journal: Journal of chemical ecology 20051101

Title: Bioconversion of (+)-valencene in submerged cultures of the ascomycete Chaetomium globosum.

Journal: Applied microbiology and biotechnology 20050601

Title: Use of novel compounds for pest control: insecticidal and acaricidal activity of essential oil components from heartwood of Alaska yellow cedar.

Journal: Journal of medical entomology 20050501

Title: Toxicity and behavioral effects of nootkatone, 1,10-dihydronootkatone, and tetrahydronootkatone to the formosan subterranean termite (Isoptera: Rhinotermitidae).

Journal: Journal of economic entomology 20040201

Title: Citrus fruit flavor and aroma biosynthesis: isolation, functional characterization, and developmental regulation of Cstps1, a key gene in the production of the sesquiterpene aroma compound valencene.

Journal: The Plant journal : for cell and molecular biology 20031201

Title: Structure-activity of valencenoid derivatives and their repellence to the Formosan subterranean termite.

Journal: Journal of chemical ecology 20031201

Title: The sesquiterpenoid nootkatone and the absolute configuration of a dibromo derivative.

Journal: Acta crystallographica. Section C, Crystal structure communications 20030501

Title: Comparative effects of vetiver oil, nootkatone and disodium octaborate tetrahydrate on Coptotermes formosanus and its symbiotic fauna.

Journal: Pest management science 20030101

Title: Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells.

Journal: In vivo (Athens, Greece) 20030101

Title: Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells.

Journal: Journal of natural products 20021001

Title: Use of nootkatone as a senescence indicator for Rouge La Toma Cv. grapefruit (Citrus paradisi Macf.).

Journal: Journal of agricultural and food chemistry 20020814

Title: Aroma composition changes in early season grapefruit juice produced from thermal concentration.

Journal: Journal of agricultural and food chemistry 20020213

Title: Modulation of radioligand binding to the GABA(A)-benzodiazepine receptor complex by a new component from Cyperus rotundus.

Journal: Biological & pharmaceutical bulletin 20020101

Title: Efficacy of vetiver oil and nootkatone as soil barriers against Formosan subterranean termite (Isoptera: Rhinotermitidae).

Journal: Journal of economic entomology 20011201

Title: Nootkatone is a repellent for Formosan subterranean termite (Coptotermes formosanus).

Journal: Journal of chemical ecology 20010301

Title: Inhibition of acetylcholinesterase activity by essential oil from Citrus paradisi.

Journal: Natural product letters 20010101

Title: Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:4674-50-4 Molecular Formula|4674-50-4 MDL|4674-50-4 SMILES|4674-50-4 Nootkatone