Title: Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20171001
Title: Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
Journal: Pharmacology & therapeutics 20170201
Title: Trichloroethylene and Its Oxidative Metabolites Enhance the Activated State and Th1 Cytokine Gene Expression in Jurkat Cells.
Journal: International journal of environmental research and public health 20150901
Title: Dichloroacetate and cancer: new home for an orphan drug?
Journal: Biochimica et biophysica acta 20141201
Title: Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.
Journal: Age (Dordrecht, Netherlands) 20140601
Title: Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.
Journal: Chemico-biological interactions 20140525
Title: Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.
Journal: Archives of toxicology 20131101
Title: Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents.
Journal: Bioorganic & medicinal chemistry letters 20121201
Title: Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism.
Journal: NMR in biomedicine 20121001
Title: Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.
Journal: Cancer research 20121001
Title: Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications.
Journal: The Journal of biological chemistry 20120928
Title: Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression.
Journal: Journal of neuroscience methods 20120815
Title: Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation.
Journal: Chemico-biological interactions 20120730
Title: Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Journal: Journal of clinical pharmacology 20120601
Title: Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats.
Journal: Biomaterials 20120601
Title: Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report.
Journal: Hepato-gastroenterology 20120601
Title: The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes.
Journal: Diabetes 20120501
Title: Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20120501
Title: Treatment for mitochondrial disorders.
Journal: The Cochrane database of systematic reviews 20120418
Title: Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells.
Journal: International journal of cancer 20120401
Title: Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction.
Journal: Molecular pharmaceutics 20120305
Title: Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301
Title: One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).
Journal: Current protocols in nucleic acid chemistry 20120301
Title: The effects of a low vitamin E diet on dichloroacetate- and trichloroacetate-induced oxidative stress in the livers of mice.
Journal: Journal of biochemical and molecular toxicology 20120301
Title: Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene.
Journal: Brain & development 20120201
Title: Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120201
Title: The role of low-level lactate production in airway inflammation in asthma.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120201
Title: Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.
Journal: Biochemical pharmacology 20120201
Title: Dichloroacetate induces different rates of cell death in cancer and noncancer cell lines in vitro.
Journal: Tumori 20120101
Title: Synergistic effect of the combination of immobilized TiO2, UVA and ozone on the decomposition of dichloroacetic acid.
Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101
Title: Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Title: Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.
Journal: PloS one 20120101
Title: Mitochondrial metabolism - neglected link of cancer transformation and treatment.
Journal: Prague medical report 20120101
Title: Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage.
Journal: PloS one 20120101
Title: Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress.
Journal: Reproductive sciences (Thousand Oaks, Calif.) 20111201
Title: In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells.
Journal: Cell proliferation 20111201
Title: The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37.
Journal: Experimental oncology 20111201
Title: Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.
Journal: Oncogene 20110922
Title: Comparative electrochemical treatments of two chlorinated aliphatic hydrocarbons. Time course of the main reaction by-products.
Journal: Journal of hazardous materials 20110915
Title: Why are there no proven therapies for genetic mitochondrial diseases?
Journal: Mitochondrion 20110901
Title: Use of oral dichloroacetate for palliation of leg pain arising from metastatic poorly differentiated carcinoma: a case report.
Journal: Journal of palliative medicine 20110801
Title: Removal of dichloroacetic acid from drinking water by using adsorptive ozonation.
Journal: Ecotoxicology (London, England) 20110701
Title: Haloacetic acids in swimming pools: swimmer and worker exposure.
Journal: Environmental science & technology 20110701
Title: [Chlorination byproducts formation potentials of typical nitrogenous organic compounds in water].
Journal: Huan jing ke xue= Huanjing kexue 20110701
Title: Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.
Journal: Circulation 20110607
Title: The effect of dichloroacetate on health- and lifespan in C. elegans.
Journal: Biogerontology 20110601
Title: Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic.
Journal: Biotechnology and bioengineering 20110601
Title: Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes.
Journal: Neurotoxicity research 20110501
Title: Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs.
Journal: Cancer chemotherapy and pharmacology 20110301
Title: Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?
Journal: International journal of cancer 20110301
Title: High concentrations of dichloroacetate have minor effects on the vitality of the mammalian nerve fibers: an ex-vivo electrophysiological study.
Journal: Anti-cancer drugs 20110301
Title: The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?
Journal: Environmental health perspectives 20110201
Title: Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells.
Journal: International journal of oncology 20110201
Title: Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
Journal: The Journal of pharmacology and experimental therapeutics 20110101
Title: Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy.
Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101
Title: Developing new anti-cancer drugs.
Journal: Recent patents on anti-cancer drug discovery 20110101
Title: In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines.
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110101
Title: On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.
Journal: Neoplasia (New York, N.Y.) 20110101
Title: Further optimization of detritylation in solid-phase oligodeoxyribonucleotide synthesis.
Journal: Nucleosides, nucleotides & nucleic acids 20110101
Title: Skeletal muscle metabolic gene expression is not affected by dichloroacetate-mediated modulation of substrate utilisation.
Journal: Annals of nutrition & metabolism 20110101
Title: Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.
Journal: BMC cancer 20110101
Title: Formation of disinfection byproducts in typical Chinese drinking water.
Journal: Journal of environmental sciences (China) 20110101
Title: Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.
Journal: Molecular cancer 20110101
Title: Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.
Journal: International journal of cancer 20101201
Title: Severe encephalopathy and polyneuropathy induced by dichloroacetate.
Journal: Journal of neurology 20101201
Title: Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.
Journal: Cancer letters 20101101
Title: Enhanced production and isotope enrichment of recombinant glycoproteins produced in cultured mammalian cells.
Journal: Journal of biomolecular NMR 20101001
Title: Potential of the TCE-degrading endophyte Pseudomonas putida W619-TCE to improve plant growth and reduce TCE phytotoxicity and evapotranspiration in poplar cuttings.
Journal: Environmental pollution (Barking, Essex : 1987) 20100901
Title: Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: design, synthesis and biological evaluation.
Journal: European journal of medicinal chemistry 20100901
Title: Electromigration diffusivity spectrometry: a way for simultaneous determination of diffusion coefficients from mixed samples.
Journal: Electrophoresis 20100901
Title: Oncology's energetic pipeline.
Journal: Nature biotechnology 20100901
Title: Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.
Journal: Human molecular genetics 20100815
Title: A simple and effective treatment for ectopic sebaceous glands on the areola.
Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20100801
Title: Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24.
Journal: Molecular and cellular biochemistry 20100701
Title: Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure.
Journal: Journal of applied toxicology : JAT 20100701
Title: Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.
Journal: British journal of cancer 20100608
Title: Novel strategy for treatment of pulmonary arterial hypertension: enhancement of apoptosis.
Journal: Lung 20100601
Title: Change of purpose.
Journal: Nature 20100520
Title: The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Journal: Cell cycle (Georgetown, Tex.) 20100515
Title: Targeting cell metabolism in cancer patients.
Journal: Science translational medicine 20100512
Title: Metabolic modulation of glioblastoma with dichloroacetate.
Journal: Science translational medicine 20100512
Title: Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure.
Journal: Circulation. Heart failure 20100501
Title: Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats.
Journal: Toxicology and applied pharmacology 20100415
Title: Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100401
Title: Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade.
Journal: Molecular genetics and metabolism 20100301
Title: The induction of tumor necrosis factor-alpha, superoxide anion, myeloperoxidase, and superoxide dismutase in the peritoneal lavage cells of mice after prolonged exposure to dichloroacetate and trichloroacetate.
Journal: Journal of biochemical and molecular toxicology 20100301
Title: Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.
Journal: Breast cancer research and treatment 20100201
Title: [Cytotoxicity of dichloroacetic acid in lymphocyte and expression of chemokine receptor CXCR2 and chemokine receptor CXCR3 mRNA].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100101
Title: Degradation of a mixture of pollutants in water using the UV/H2O2 process.
Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20100101
Title: Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products.
Journal: Environmental and molecular mutagenesis 20100101
Title: Enhanced ozonation of dichloroacetic acid in aqueous solution using nanometer ZnO powders.
Journal: Journal of environmental sciences (China) 20100101
Title: Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.
Journal: The Journal of biological chemistry 20091204
Title: Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091201
Title: Effects of crystalline structures and surface functional groups on the adsorption of haloacetic acids by inorganic materials.
Journal: Journal of hazardous materials 20091115
Title: In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells.
Journal: Anticancer research 20091101
Title: Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation.
Journal: Journal of proteome research 20091001
Title: Influence of dichloroacetate on pulmonary gas exchange and ventilation during incremental exercise in healthy humans.
Journal: Respiratory physiology & neurobiology 20090930
Title: Zero-valent aluminum for oxidative degradation of aqueous organic pollutants.
Journal: Environmental science & technology 20090915
Title: Kinetics and effects of dichloroacetic acid in rainbow trout.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20090914
Title: Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD.
Journal: Chest 20090901
Title: Peripheral neuropathy in rats exposed to dichloroacetate.
Journal: Journal of neuropathology and experimental neurology 20090901
Title: Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Journal: Toxicology 20090821
Title: High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.
Journal: Journal of molecular and cellular cardiology 20090701
Title: Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Journal: Toxicology and applied pharmacology 20090701
Title: Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta.
Journal: Biochemical pharmacology 20090415
Title: Treatment for Leigh syndrome by monitoring dichloroacetate concentration.
Journal: Pediatrics international : official journal of the Japan Pediatric Society 20090401
Title: Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy.
Journal: Circulation research 20090327
Title: Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.
Journal: Circulation research 20090327
Title: Fate of THMs and HAAs in low TOC surface water.
Journal: Environmental research 20090201
Title: The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution.
Journal: Organic & biomolecular chemistry 20090107
Title: Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090101
Title: Therapeutic targets in pulmonary arterial hypertension.
Journal: Pharmacology & therapeutics 20090101
Title: Determination of ten haloacetic acids in drinking water using high-performance and ultra-performance liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatographic science 20090101
Title: The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina.
Journal: Current pharmaceutical design 20090101
Title: Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice.
Journal: Arthritis research & therapy 20090101
Title: Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.
Journal: PloS one 20090101
Title: Dichloroacetate-induced modulation of cellular antioxidant enzyme activities and glutathione level in the J774A.1 cells.
Journal: Journal of applied toxicology : JAT 20081101
Title: Visible light photo-oxidations in the presence of alpha-Bi(2)O(3).
Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20081101
Title: Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer.
Journal: British journal of cancer 20081007
Title: Differential effects of in vivo and in vitro lactate treatments on liver carbohydrate metabolism of rainbow trout.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081001
Title: Theoretical studies of different tautomers of anti cancer drug: dichloroacetate.
Journal: Pakistan journal of pharmaceutical sciences 20081001
Title: The heme precursor delta-aminolevulinate blocks peripheral myelin formation.
Journal: Journal of neurochemistry 20080901
Title: Comparison of H2O2/UV and heterogeneous photocatalytic processes for the degradation of dichloroacetic acid in water.
Journal: Environmental science & technology 20080815
Title: Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation.
Journal: The Prostate 20080801
Title: Case: asymptomatic lesions on eyelids.
Journal: Geriatrics 20080801
Title: Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation.
Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080701
Title: Metabolic agents in the management of diabetic coronary patients: a new era.
Journal: International journal of cardiology 20080623
Title: Metabolic agents in the management of diabetic coronary patients: a new era.
Journal: International journal of cardiology 20080623
Title: Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.
Journal: American journal of physiology. Heart and circulatory physiology 20080601
Title: Dichloroacetate induces apoptosis in endometrial cancer cells.
Journal: Gynecologic oncology 20080601
Title: Oxidoreductase regulation of Kv currents in rat ventricle.
Journal: Journal of molecular and cellular cardiology 20080601
Title: Dichloroacetate enhances performance and reduces blood lactate during maximal cycle exercise in chronic obstructive pulmonary disease.
Journal: American journal of respiratory and critical care medicine 20080515
Title: Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.
Journal: Pediatrics 20080501
Title: A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.
Journal: Molecular genetics and metabolism 20080401
Title: Quantitative evaluation of dichloroacetic acid kinetics in human--a physiologically based pharmacokinetic modeling investigation.
Journal: Toxicology 20080312
Title: Kinetics of chloral hydrate and its metabolites in male human volunteers.
Journal: Toxicology 20080312
Title: Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.
Journal: The Journal of pharmacology and experimental therapeutics 20080301
Title: Treatment of Fordyce spots with bichloracetic acid.
Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20080301
Title: Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure.
Journal: Journal of biochemical and molecular toxicology 20080201
Title: Role of dichloroacetate in the treatment of genetic mitochondrial diseases.
Journal: Advanced drug delivery reviews 20080101
Title: Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.
Journal: Critical reviews in toxicology 20080101
Title: Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101
Title: MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.
Journal: Analytical chemistry 20071101
Title: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.
Journal: Structure (London, England : 1993) 20070801
Title: Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.
Journal: FEBS letters 20070626
Title: Lactate interferes with ATP release from red blood cells.
Journal: American journal of physiology. Heart and circulatory physiology 20070601
Title: The beneficial effects of dichloroacetate in acute limb ischemia.
Journal: Military medicine 20070601
Title: Trials and tribulations.
Journal: Nature reviews. Drug discovery 20070501
Title: Metabolic targeting as an anticancer strategy: dawn of a new era?
Journal: Science's STKE : signal transduction knowledge environment 20070410
Title: NTP report on the toxicology studies of dichloroacetic acid (CAS No. 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water studies).
Journal: National Toxicology Program genetically modified model report 20070401
Title: Cancer patients opt for unapproved drug.
Journal: Nature 20070329
Title: Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts.
Journal: Fertility and sterility 20070301
Title: Malonyl coenzyme A affects insulin-stimulated glucose transport in myotubes.
Journal: Archives of physiology and biochemistry 20070201
Title: Dichloroacetic acid degradation employing hydrogen peroxide and UV radiation.
Journal: Chemosphere 20070101
Title: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Journal: Cancer cell 20070101
Title: Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect.
Journal: Journal of neurochemistry 20070101
Title: Modelling the kinetics of UV/H2O2 oxidation of dichloroacetic acid.
Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20070101
Title: Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.
Journal: Journal of clinical pharmacology 20061201
Title: [Study on rat's DNA damage of p53 induced by chlorinated acetic acids of drinking water disinfection by-products].
Journal: Wei sheng yan jiu = Journal of hygiene research 20061101
Title: Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.
Journal: Toxicology and applied pharmacology 20061015
Title: Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.
Journal: Neurology 20061010
Title: Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20061001
Title: Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.
Journal: Regulatory toxicology and pharmacology : RTP 20061001
Title: Severe malaria: lessons learned from the management of critical illness in children.
Journal: Trends in parasitology 20061001
Title: New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.
Journal: Anesthesiology 20061001
Title: Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake.
Journal: Pflugers Archiv : European journal of physiology 20060901
Title: The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901
Title: Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.
Journal: Seminars in cardiothoracic and vascular anesthesia 20060901
Title: Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Journal: Environmental health perspectives 20060901
Title: Modeling dichloroacetic acid formation from the reaction of monochloramine with natural organic matter.
Journal: Water research 20060801
Title: Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.
Journal: Neurology 20060711
Title: Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060701
Title: An evidence-based approach to the management of pulmonary arterial hypertension.
Journal: Current opinion in cardiology 20060701
Title: A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606
Title: An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Journal: Circulation 20060606
Title: Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.
Journal: Mitochondrion 20060601
Title: Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.
Journal: Biochemical pharmacology 20060528
Title: Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.
Journal: Pediatrics 20060501
Title: [Determination of trace haloacetic acids in drinking water using ion chromatography coupled with solid phase extraction].
Journal: Se pu = Chinese journal of chromatography 20060501
Title: Dichloroacetate reduces tissue necrosis in a rat transverse rectus abdominis musculocutaneous flap model.
Journal: Annals of plastic surgery 20060301
Title: Severe malaria: metabolic complications.
Journal: Current molecular medicine 20060301
Title: Trial of dichloroacetate in MELAS: toxicity overshadows the assessment of potential benefit.
Journal: Neurology 20060214
Title: Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.
Journal: Neurology 20060214
Title: Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.
Journal: The Journal of pharmacology and experimental therapeutics 20060201
Title: Treatment for mitochondrial disorders.
Journal: The Cochrane database of systematic reviews 20060125
Title: Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.
Journal: Biochemistry 20060117
Title: Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101
Title: The effects of cyanobacterial exudates on bacterial growth and biodegradation of organic contaminants.
Journal: Microbial ecology 20060101
Title: Pulmonary arterial hypertension: new insights and new hope.
Journal: Respirology (Carlton, Vic.) 20060101
Title: A case of Melas (A3243G) on chronic dichloroacetate treatment.
Journal: European neurology 20060101
Title: Different net effect of TiO2 sintering temperature on the photocatalytic removal rates of 4-chlorophenol, 4-chlorobenzoic acid and dichloroacetic acid in water.
Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101
Title: Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.
Journal: Molecular genetics and metabolism 20060101
Title: Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect eye development in the Sprague-Dawley rat?
Journal: International journal of toxicology 20060101
Title: Modulation by ellagic acid of DCA-induced developmental toxicity in the zebrafish (Danio rerio).
Journal: Journal of biochemical and molecular toxicology 20060101
Title: Malaria and fluids--balancing acts.
Journal: Trends in parasitology 20051201
Title: Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS.
Journal: Mitochondrion 20051201
Title: Comparison of haloacetic acids in the environment of the Northern and Southern Hemispheres.
Journal: Environmental science & technology 20051115
Title: Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage.
Journal: Respiratory physiology & neurobiology 20051012
Title: A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid.
Journal: Biomedical chromatography : BMC 20051001
Title: DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20051001
Title: The relevance of malaria pathophysiology to strategies of clinical management.
Journal: Current opinion in infectious diseases 20051001
Title: Fructose-1,6-bisphosphate enhances hypothermic preservation of cardiac myocytes.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050901
Title: Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.
Journal: Toxicology 20050801
Title: The impacts of cyanobacteria on pulp-and-paper wastewater toxicity and biodegradation of wastewater contaminants.
Journal: Canadian journal of microbiology 20050701
Title: Determination of dichloroacetic acid and trichloroacetic acid in drinking water by acidic methanol esterification and headspace gas chromatography.
Journal: Water research 20050501
Title: [Adsorption performance of haloacetic acids onto 5 GACs from water].
Journal: Huan jing ke xue= Huanjing kexue 20050501
Title: Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart.
Journal: Circulation 20050426
Title: Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy.
Journal: Biochemistry 20050322
Title: Redox regulation of Ito remodeling in diabetic rat heart.
Journal: American journal of physiology. Heart and circulatory physiology 20050301
Title: Modulation of the expression of vascular endothelial growth factor in human fibroblasts.
Journal: Fertility and sterility 20050201
Title: Chasing the 'ghost' of the acetyl group deficit.
Journal: Medicine and science in sports and exercise 20050101
Title: Dichloroacetate-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos.
Journal: Journal of biochemical and molecular toxicology 20050101
Title: Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.
Journal: The Journal of physiology 20041215
Title: A quantitative description of suicide inhibition of dichloroacetic acid in rats and mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041201
Title: Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20041101
Title: Muscle mechanoreceptor sensitivity in heart failure.
Journal: American journal of physiology. Heart and circulatory physiology 20041101
Title: Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
Journal: Biochemistry 20041026
Title: Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.
Journal: Toxicology 20041015
Title: Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.
Journal: Circulation research 20041015
Title: Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Journal: Brain & development 20041001
Title: Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron.
Journal: Journal of contaminant hydrology 20041001
Title: Binding and kinetic mechanisms of the Zeta class glutathione transferase.
Journal: The Journal of biological chemistry 20040806
Title: Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis.
Journal: Metabolism: clinical and experimental 20040801
Title: Ischemic heart disease: metabolic approaches to management.
Journal: Clinical cardiology 20040801
Title: Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice.
Journal: Toxicology 20040701
Title: Influence of DCA on pulmonary (.-)V(O2) kinetics during moderate-intensity cycle exercise.
Journal: Medicine and science in sports and exercise 20040701
Title: Effects of dichloroacetate and ubiquinone infusions on glycolysis activity and thermal sensitivity during sepsis.
Journal: The Journal of laboratory and clinical medicine 20040601
Title: Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.
Journal: Chemical research in toxicology 20040501
Title: Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.
Journal: The Journal of clinical endocrinology and metabolism 20040401
Title: Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.
Journal: American journal of obstetrics and gynecology 20040401
Title: Dichloroacetate does not speed phase-II pulmonary VO2 kinetics following the onset of heavy intensity cycle exercise.
Journal: Pflugers Archiv : European journal of physiology 20040301
Title: [Treatment for mitochondrial diseases].
Journal: No to hattatsu = Brain and development 20040301
Title: Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Journal: Toxicology 20040301
Title: Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040201
Title: Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS.
Journal: Neurology 20040127
Title: Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.
Journal: Fertility and sterility 20040101
Title: Mechanistic implications of the effect of TiO2 accessibility in TiO2-SiO2 coatings upon chlorinated organics photocatalytic removal in water.
Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20040101
Title: Evaluation of the combined solar TiO2/photo-Fenton process using multivariate analysis.
Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20040101
Title: Elevated blood lactate is not a primary cause of anorexia in tumor-bearing rats.
Journal: Nutrition and cancer 20040101
Title: Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit - the role of buffers.
Journal: Critical care (London, England) 20040101
Title: Chronic treatment of mitochondrial disease patients with dichloroacetate.
Journal: Molecular genetics and metabolism 20040101
Title: Some drinking-water disinfectants and contaminants, including arsenic.
Journal: IARC monographs on the evaluation of carcinogenic risks to humans 20040101
Title: Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.
Journal: IARC monographs on the evaluation of carcinogenic risks to humans 20040101
Title: Evaluation of the influence of chloroacetic acids on the pharmacokinetics of trihalomethanes in the rat.
Journal: Journal of toxicology and environmental health. Part A 20031212
Title: Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.
Journal: Biochemical pharmacology 20031115
Title: Lactate as a modulator of hypoxia-induced hyperventilation.
Journal: Respiratory physiology & neurobiology 20031016
Title: Improvement of thermal hydrolysis rate of dichloroacetic acid using alcohol.
Journal: Chemosphere 20031001
Title: Pyruvate and acetate metabolism in termite mitochondria.
Journal: Journal of insect physiology 20031001
Title: The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion.
Journal: Journal of the American College of Surgeons 20031001
Title: Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20030901
Title: Low-frequency modes of peptides and globular proteins in solution observed by ultrafast OHD-RIKES spectroscopy.
Journal: Biophysical journal 20030901
Title: Evidence for rapid 'metabolic switching' through lipoprotein lipase occupation of endothelial-binding sites.
Journal: Journal of molecular and cellular cardiology 20030901
Title: Multinuclear NMR investigations on the metabolic recovery of the isolated perfused mouse liver after cold preservation.
Journal: Biochimie 20030901
Title: Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.
Journal: Circulation research 20030808
Title: Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030701
Title: Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.
Journal: American journal of physiology. Heart and circulatory physiology 20030701
Title: Efficacy of dichloroacetate as a lactate-lowering drug.
Journal: Journal of clinical pharmacology 20030701
Title: The induction of oxidative stress and cellular death by the drinking water disinfection by-products, dichloroacetate and trichloroacetate in J774.A1 cells.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030601
Title: Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin.
Journal: Journal of chromatography. A 20030516
Title: Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency.
Journal: Pediatric research 20030501
Title: Field level evaluation and risk assessment of the toxicity of dichloroacetic acid to the aquatic macrophytes Lemna gibba, Myriophyllum spicatum, and Myriophyllum sibiricum.
Journal: Ecotoxicology and environmental safety 20030501
Title: Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.
Journal: Fertility and sterility 20030501
Title: Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.
Journal: Journal of clinical pharmacology 20030401
Title: [Dichloroacetate treatment for adult patients with mitochondrial disease].
Journal: Rinsho shinkeigaku = Clinical neurology 20030401
Title: Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes.
Journal: Electrophoresis 20030301
Title: Altered gene expression in mouse livers after dichloroacetic acid exposure.
Journal: Mutation research 20030301
Title: Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030201
Title: A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid.
Journal: Environmental health perspectives 20030101
Title: [Adverse effects of dichloroacetate in a girl with mitochondrial disorder].
Journal: No to hattatsu = Brain and development 20030101
Title: Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia.
Journal: Vascular and endovascular surgery 20030101
Title: The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.
Journal: Advances in experimental medicine and biology 20030101
Title: Nephrotoxicity of chlorofluoroacetic acid in rats.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20021201
Title: Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid.
Journal: American journal of obstetrics and gynecology 20021201
Title: Brief increase in carbohydrate oxidation after reperfusion reverses myocardial stunning in conscious pigs.
Journal: Circulation 20021126
Title: Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta.
Journal: Chemical research in toxicology 20021101
Title: [Acute complications due to diabetes mellitus: Lactic acidosis].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20021001
Title: Is lactate a mediator of hypoxia-induced anapyrexia?
Journal: Pflugers Archiv : European journal of physiology 20020901
Title: Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020801
Title: Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats.
Journal: Environmental health perspectives 20020801
Title: Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise.
Journal: American journal of physiology. Endocrinology and metabolism 20020701
Title: Manipulations in glycogen metabolism and the failure to influence infarct size in the ischaemic rabbit heart.
Journal: European journal of anaesthesiology 20020701
Title: Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).
Journal: Chemical research in toxicology 20020701
Title: Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.
Journal: Toxicology and applied pharmacology 20020701
Title: Solar photodegradation of dichloroacetic acid and 2,4-dichlorophenol using an enhanced photo-Fenton process.
Journal: Chemosphere 20020701
Title: Dichloroacetate therapy in Leigh syndrome with a mitochondrial T8993C mutation.
Journal: Pediatric neurology 20020701
Title: Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020601
Title: Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor.
Journal: Toxicology 20020501
Title: [Drug therapy for mitochondrial diseases].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020401
Title: Genetic polymorphisms in assessing interindividual variability in delivered dose.
Journal: Regulatory toxicology and pharmacology : RTP 20020401
Title: Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets.
Journal: Biochemical and biophysical research communications 20020308
Title: Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries.
Journal: The Journal of physiology 20020215
Title: Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Journal: Circulation 20020115
Title: Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020101
Title: Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate.
Journal: The Journal of physiology 20020101
Title: Renal manifestations of congenital lactic acidosis.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101
Title: Mouse models of Huntington's disease.
Journal: Trends in pharmacological sciences 20020101
Title: Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance.
Journal: American journal of respiratory and critical care medicine 20011101
Title: Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice.
Journal: Carcinogenesis 20010901
Title: Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid.
Journal: Carcinogenesis 20010801
Title: Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate.
Journal: Muscle & nerve 20010701
Title: Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.
Journal: Annals of neurology 20010701
Title: Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010601
Title: Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak.
Journal: American journal of physiology. Heart and circulatory physiology 20010401
Title: Direct imaging of dehydrogenase activity within living cells using enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP).
Journal: Biophysical journal 20010401
Title: Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model.
Journal: Journal of clinical pharmacology 20010301
Title: Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis.
Journal: The Pediatric infectious disease journal 20010201
Title: The fate and persistence of trifluoroacetic and chloroacetic acids in pond waters.
Journal: Chemosphere 20010101
Title: Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010101
Title: The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice.
Journal: Journal of biochemical and molecular toxicology 20010101
Title: Lack of IL-6 production during exercise in patients with mitochondrial myopathy.
Journal: European journal of applied physiology 20010101
Title: [Benign infantile mitochondrial myopathy].
Journal: Ryoikibetsu shokogun shirizu 20010101
Title: Solar detoxification of wastewater in a novel aerated cascade photoreactor (ACP).
Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20010101
Title: Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.
Journal: Advances in experimental medicine and biology 20010101
Title: Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development?
Journal: International journal of toxicology 20010101
Title: Role of metabolically active drugs in the management of ischemic heart disease.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101
Title: Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20000401
Title: Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.
Journal: Pharmacogenetics 20000201
Title: The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.
Journal: Cell biology and toxicology 20000101
Title: Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate.
Journal: Research communications in molecular pathology and pharmacology 20000101
Title: Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.
Journal: Biochemical and biophysical research communications 19990907
Title: Loss of heterozygosity on chromosome 6 in dichloroacetic acid and trichloroacetic acid-induced liver tumors in female B6C3F1 mice.
Journal: Cancer letters 19961129
Title: Effects of chemical pretreatment on posttraumatic cortical edema in the rat.
Journal: The American journal of emergency medicine 19960101
Title: ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.
Journal: Carcinogenesis 19941001
Title: The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.
Journal: Toxicology and applied pharmacology 19870915
Title: Toxic effects of chlorinated and brominated alkanoic acids on Pseudomonas putida PP3: selection at high frequencies of mutations in genes encoding dehalogenases.
Journal: Applied and environmental microbiology 19850601
Title: Bufuralol, a new beta-adrenoceptor blocking agent.
Journal: Experientia 19751115
Title: Stakišaitis D, et al. The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo. Cancers (Basel). 2019 Aug 20;11(8). pii: E1210.
