58-46-8,MFCD00042740
Catalog No.:AA003UJN

58-46-8 | 9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one

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Purity
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10mg
≥98% (mixture of enantiomers)
in stock  
$46.00   $32.00
- +
250mg
98%(HPLC)
in stock  
$62.00   $44.00
- +
1g
98%(HPLC)
in stock  
$183.00   $128.00
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5g
98%(HPLC)
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  • Technical Information
  • Properties
  • Literature
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Technical Information
Catalog Number:
AA003UJN
Chemical Name:
9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one
CAS Number:
58-46-8
Molecular Formula:
C19H27NO3
Molecular Weight:
317.4226
MDL Number:
MFCD00042740
SMILES:
COc1cc2c(cc1OC)CCN1C2CC(=O)C(C1)CC(C)C
Properties
Properties
 
BP:
456.71°C (rough estimate)  
Form:
Solid  
MP:
128-130?C  
Refractive Index:
1.5180 (estimate)  
Solubility:
DMSO: >10mg/mL  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
425  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.9  

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Title: Treatment of chorea associated with Huntington's disease: focus on tetrabenazine.

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Journal: The Journal of organic chemistry 20090515

Title: Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.

Journal: Parkinsonism & related disorders 20090501

Title: Paroxysmal dyskinesias.

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Title: Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome.

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Title: PET demonstrates reduced dopamine transporter expression in PD with dyskinesias.

Journal: Neurology 20090407

Title: Dyskinesia in Parkinson disease: back for the future?

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Title: Pancreatic imaging with 11C-dihydrotetrabenazine PET: a perspective.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090301

Title: 11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.

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Title: Tetrabenazine (Xenazine) for Huntington's chorea.

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Journal: Indian journal of psychiatry 20090101

Title: Treatment of Tardive Dyskinesia by tetrabenazine, clonazepam and vitamin E.

Journal: Indian journal of psychiatry 20090101

Title: Chorea-ballismus in acute non-ketotic hyperglycaemia.

Journal: Functional neurology 20090101

Title: Tetrabenazine as anti-chorea therapy in Huntington disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators.

Journal: BMC neurology 20090101

Title: Amoxapine-induced tardive dyskinesia.

Journal: Indian journal of psychiatry 20090101

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Title: Olanzapine induced tardive dystonia in case of adolescent bipolar disorder.

Journal: Journal of pediatric neurosciences 20090101

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Journal: Journal of neurochemistry 20081201

Title: Tetrabenazine (Xenazine), An FDA-Approved Treatment Option For Huntington's Disease-Related Chorea.

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Title: Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration.

Journal: Synapse (New York, N.Y.) 20081101

Title: Increased beta activity in dystonia patients after drug-induced dopamine deficiency.

Journal: Experimental neurology 20081101

Title: In vivo imaging of vesicular monoamine transporter 2 in pancreas using an (18)F epoxide derivative of tetrabenazine.

Journal: Nuclear medicine and biology 20081101

Title: Gene therapy offers HD patients relief from some symptoms. Tetrabenazine inhibits the transport of a molecule called vesicular monoamine transporter type 2 or VMAT2.

Journal: Managed care (Langhorne, Pa.) 20081101

Title: Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080924

Title: Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20080915

Title: Anterocollis: clinical features and treatment options.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20080901

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Journal: Current neuropharmacology 20080901

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Journal: Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent 20080801

Title: In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701

Title: Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.

Journal: The Journal of endocrinology 20080701

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Journal: European journal of nuclear medicine and molecular imaging 20080401

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Journal: Journal of child neurology 20080401

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Journal: Clinical drug investigation 20080101

Title: Differentiating Alzheimer's disease from dementia with Lewy bodies and Parkinson's disease with (+)-[11C]dihydrotetrabenazine positron emission tomography.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association 20080101

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Journal: Journal of the American Pharmacists Association : JAPhA 20080101

Title: The long-term effect of tetrabenazine in the management of Huntington disease.

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Journal: Journal of neurogenetics 20080101

Title: Identification of the substrate binding region of vesicular monoamine transporter-2 (VMAT-2) using iodoaminoflisopolol as a novel photoprobe.

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Title: PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20071001

Title: Tetrabenazine in the treatment of Huntington's disease.

Journal: Neuropsychiatric disease and treatment 20071001

Title: Drug-induced tardive motor syndromes.

Journal: Psychiatrike = Psychiatriki 20071001

Title: Specific derivatization of the vesicle monoamine transporter with novel carrier-free radioiodinated reserpine and tetrabenazine photoaffinity labels.

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Title: In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070701

Title: Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070701

Title: Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice.

Journal: Journal of ethnopharmacology 20070530

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Journal: Nuclear medicine and biology 20070401

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Title: Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders.

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Journal: Movement disorders : official journal of the Movement Disorder Society 20070101

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Journal: The Journal of neuropsychiatry and clinical neurosciences 20070101

Title: Parkinsonism and tremor disorders. A clinical approach.

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Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

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Title: Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population.

Journal: Behavioral and brain functions : BBF 20060101

Title: Eating dysfunction associated with oromandibular dystonia: clinical characteristics and treatment considerations.

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Journal: Endocrinology 20041001

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Journal: Brain : a journal of neurology 20031201

Title: Raclopride studies of dopamine release: dependence on presynaptic integrity.

Journal: Biological psychiatry 20031201

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Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001

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Journal: Journal of neurology, neurosurgery, and psychiatry 19991001

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Tags:58-46-8 Molecular Formula|58-46-8 MDL|58-46-8 SMILES|58-46-8 9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one
Catalog No.: AA003UJN
58-46-8,MFCD00042740
58-46-8 | 9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one
Pack Size: 10mg
Purity: ≥98% (mixture of enantiomers)
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$46.00 $32.00
Pack Size: 250mg
Purity: 98%(HPLC)
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$62.00 $44.00
Pack Size: 1g
Purity: 98%(HPLC)
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Pack Size: 5g
Purity: 98%(HPLC)
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Technical Information
Catalog Number: AA003UJN
Chemical Name: 9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one
CAS Number: 58-46-8
Molecular Formula: C19H27NO3
Molecular Weight: 317.4226
MDL Number: MFCD00042740
SMILES: COc1cc2c(cc1OC)CCN1C2CC(=O)C(C1)CC(C)C
Properties
BP: 456.71°C (rough estimate)  
Form: Solid  
MP: 128-130?C  
Refractive Index: 1.5180 (estimate)  
Solubility: DMSO: >10mg/mL  
Storage: 2-8℃;  
Complexity: 425  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 2  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.9  
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Title: In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20080701

Title: Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.

Journal: The Journal of endocrinology20080701

Title: Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine.

Journal: Journal of neurochemistry20080601

Title: Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens.

Journal: Journal of neurochemistry20080601

Title: Camptocormia: a rare axial myopathy disease.

Journal: Clinics (Sao Paulo, Brazil)20080601

Title: Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole hemisphere autoradiography.

Journal: Psychiatry research20080530

Title: Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

Journal: Human molecular genetics20080515

Title: Treatment of tardive dyskinesia with levetiracetam in a transplant patient.

Journal: Acta neurologica Scandinavica20080501

Title: [Severe generalized dystonia due to postradiotherapy cerebral calcifications].

Journal: Revue neurologique20080501

Title: VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.

Journal: Journal of neurochemistry20080401

Title: Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates.

Journal: European journal of nuclear medicine and molecular imaging20080401

Title: Comparison of weight gain in treatments for Tourette syndrome: tetrabenazine versus neuroleptic drugs.

Journal: Journal of child neurology20080401

Title: Expression and function of the rat vesicular monoamine transporter 2.

Journal: American journal of physiology. Cell physiology20080401

Title: Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease.

Journal: Annals of neurology20080301

Title: [A comparison of the pharmacology of (-)-deprenyl to N-methylpropargylamine-1-aminoindane (J-508) and rasagiline, the desmethyl-analogue of J-508].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology20080301

Title: Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study.

Journal: Journal of medicinal chemistry20080227

Title: [Quick and simple synthesis of (11)C-(+)-alpha-dihydrotetrabenazine to be used as a PET radioligand of vesicular monoamine transporters].

Journal: Revista espanola de medicina nuclear20080101

Title: [Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease].

Journal: Revista espanola de medicina nuclear20080101

Title: A study of chorea after tetrabenazine withdrawal in patients with Huntington disease.

Journal: Clinical neuropharmacology20080101

Title: Tourette's syndrome and role of tetrabenazine: review and personal experience.

Journal: Clinical drug investigation20080101

Title: Differentiating Alzheimer's disease from dementia with Lewy bodies and Parkinson's disease with (+)-[11C]dihydrotetrabenazine positron emission tomography.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association20080101

Title: New drugs: Clevidipine butyrate, difluprednate, and tetrabenazine.

Journal: Journal of the American Pharmacists Association : JAPhA20080101

Title: The long-term effect of tetrabenazine in the management of Huntington disease.

Journal: Clinical neuropharmacology20080101

Title: Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia.

Journal: Journal of neurogenetics20080101

Title: Identification of the substrate binding region of vesicular monoamine transporter-2 (VMAT-2) using iodoaminoflisopolol as a novel photoprobe.

Journal: Molecular pharmacology20071201

Title: Neurotransmitter depleter tetrabenazine; potential candidate for schizophrenia treatment?

Journal: Schizophrenia research20071101

Title: PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20071001

Title: Tetrabenazine in the treatment of Huntington's disease.

Journal: Neuropsychiatric disease and treatment20071001

Title: Drug-induced tardive motor syndromes.

Journal: Psychiatrike = Psychiatriki20071001

Title: Specific derivatization of the vesicle monoamine transporter with novel carrier-free radioiodinated reserpine and tetrabenazine photoaffinity labels.

Journal: Analytical biochemistry20070801

Title: Dopaminergic signaling and striatal neurodegeneration in Huntington's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20070725

Title: Neurotoxicity in murine striatal dopaminergic pathways following long-term application of low doses of permethrin and MPTP.

Journal: Toxicology letters20070710

Title: In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20070701

Title: Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20070701

Title: Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice.

Journal: Journal of ethnopharmacology20070530

Title: Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells.

Journal: American journal of physiology. Renal physiology20070501

Title: Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.

Journal: Bioorganic & medicinal chemistry20070415

Title: Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain.

Journal: Nuclear medicine and biology20070401

Title: Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters.

Journal: Nuclear medicine and biology20070401

Title: Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial.

Journal: Neurology20070306

Title: A systematic review of the treatment studies in Huntington's disease since 1990.

Journal: Expert opinion on pharmacotherapy20070201

Title: Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders.

Journal: Movement disorders : official journal of the Movement Disorder Society20070115

Title: Short-term effects of tetrabenazine on chorea associated with Huntington's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society20070101

Title: Olanzapine-induced tardive dystonia successfully treated by tetrabenazine.

Journal: The Journal of neuropsychiatry and clinical neurosciences20070101

Title: Parkinsonism and tremor disorders. A clinical approach.

Journal: The Libyan journal of medicine20070101

Title: Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice.

Journal: Neurochemistry international20061201

Title: Vesicular monoamine transporter 2: role as a novel target for drug development.

Journal: The AAPS journal20061201

Title: Therapeutic Strategies in Huntington's Disease.

Journal: Journal of clinical neurology (Seoul, Korea)20061201

Title: Tetrabenazine therapy of pediatric hyperkinetic movement disorders.

Journal: Movement disorders : official journal of the Movement Disorder Society20061101

Title: Tetrabenazine for hyperglycemic-induced hemichorea-hemiballismus.

Journal: Movement disorders : official journal of the Movement Disorder Society20061101

Title: [The study and treatment of dystonias in childhood].

Journal: Revista de neurologia20061010

Title: Interaction of amphetamines and related compounds at the vesicular monoamine transporter.

Journal: The Journal of pharmacology and experimental therapeutics20061001

Title: Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?

Journal: Nature clinical practice. Neurology20061001

Title: Visualizing pancreatic beta-cell mass with [11C]DTBZ.

Journal: Nuclear medicine and biology20061001

Title: Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20060901

Title: Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters.

Journal: Nuclear medicine and biology20060801

Title: Measurement of kinetically resolved vesicular dopamine uptake and efflux using rotating disk electrode voltammetry.

Journal: Journal of neuroscience methods20060715

Title: Tetrabenazine versus placebo for chorea in Huntington's disease.

Journal: Current neurology and neuroscience reports20060701

Title: Partial depletion of dopamine in substantia nigra impairs motor performance without altering striatal dopamine neurotransmission.

Journal: The European journal of neuroscience20060701

Title: Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.

Journal: The Journal of clinical investigation20060601

Title: Huntington's Disease.

Journal: Current treatment options in neurology20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial.

Journal: Neurology20060214

Title: A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitis.

Journal: Movement disorders : official journal of the Movement Disorder Society20060101

Title: Tetrabenazine in the treatment of hyperkinetic movement disorders.

Journal: Expert review of neurotherapeutics20060101

Title: Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series.

Journal: BMC neurology20060101

Title: Pharmacological management of Huntington's disease: an evidence-based review.

Journal: Current pharmaceutical design20060101

Title: Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging20060101

Title: Is history of depression a contraindication to treatment with tetrabenazine?

Journal: Clinical neuropharmacology20060101

Title: Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population.

Journal: Behavioral and brain functions : BBF20060101

Title: Eating dysfunction associated with oromandibular dystonia: clinical characteristics and treatment considerations.

Journal: Head & face medicine20060101

Title: PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.

Journal: Brain : a journal of neurology20051201

Title: Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects.

Journal: International clinical psychopharmacology20051101

Title: Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia.

Journal: Psychiatry research20050915

Title: Management of the extrapyramidal syndrome in chronic acquired hepatocerebral degeneration (CAHD).

Journal: Movement disorders : official journal of the Movement Disorder Society20050801

Title: The influence of measurement uncertainties on the evaluation of the distribution volume ratio and binding potential in rat studies on a microPET R4: a phantom study.

Journal: Physics in medicine and biology20050621

Title: 11C-DTBZ and 18F-FDG PET measures in differentiating dementias.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20050601

Title: Emerging drugs in Tourette syndrome.

Journal: Expert opinion on emerging drugs20050501

Title: Antidepressant properties of some Hypericum canariense L. and Hypericum glandulosum Ait. extracts in the forced swimming test in mice.

Journal: Journal of ethnopharmacology20050321

Title: Decreased platelet vesicular monoamine transporter density in children and adolescents with attention deficit/hyperactivity disorder.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20050301

Title: Decreased platelet vesicular monoamine transporter density in habitual smokers.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20050301

Title: The role of radiotracer imaging in Parkinson disease.

Journal: Neurology20050125

Title: Lack of regional selectivity during the progression of Parkinson disease: implications for pathogenesis.

Journal: Archives of neurology20041201

Title: Identification of tissue-restricted transcripts in human islets.

Journal: Endocrinology20041001

Title: Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.

Journal: The Journal of pharmacology and experimental therapeutics20040901

Title: The effect of rare human sequence variants on the function of vesicular monoamine transporter 2.

Journal: Pharmacogenetics20040901

Title: Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain.

Journal: Experimental neurology20040801

Title: PET studies and physiopathology of motor fluctuations in Parkinson's disease.

Journal: Brain : a journal of neurology20040801

Title: [Movement disorders in childhood: therapeutic update].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie20040801

Title: Adrafinil-induced orofacial dyskinesia.

Journal: Movement disorders : official journal of the Movement Disorder Society20040801

Title: Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20040701

Title: Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain.

Journal: Nuclear medicine and biology20040701

Title: Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease.

Journal: Annals of neurology20040601

Title: Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes.

Journal: Journal of neuroscience methods20040215

Title: Dopamine transmission in DYT1 dystonia.

Journal: Advances in neurology20040101

Title: Behavioural effects of thieno and pyrazolo [2,1] benzothiazepine derivatives in mice.

Journal: Arzneimittel-Forschung20040101

Title: Tetrabenazine treatment in movement disorders.

Journal: Clinical neuropharmacology20040101

Title: [11C]DTBZ-PET correlates of levodopa responses in asymmetric Parkinson's disease.

Journal: Brain : a journal of neurology20031201

Title: Raclopride studies of dopamine release: dependence on presynaptic integrity.

Journal: Biological psychiatry20031201

Title: Apparent opposite effects of tetrabenazine and reserpine on the toxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine on nigro-striatal dopaminergic neurons.

Journal: Brain research20031107

Title: Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease.

Journal: Experimental neurology20031101

Title: Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20031001

Title: Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons.

Journal: The European journal of neuroscience20030901

Title: Increased ventral striatal monoaminergic innervation in Tourette syndrome.

Journal: Neurology20030812

Title: Huntington's disease: prospects for neuroprotective therapy 10 years after the discovery of the causative genetic mutation.

Journal: Current opinion in neurology20030801

Title: REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA.

Journal: Neurology20030708

Title: Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA.

Journal: Neurology20030708

Title: VMAT2 binding is elevated in dopa-responsive dystonia: visualizing empty vesicles by PET.

Journal: Synapse (New York, N.Y.)20030701

Title: Pharmacological management of tics in patients with TS.

Journal: Journal of psychosomatic research20030701

Title: Tetrabenazine in the treatment of severe pediatric chorea.

Journal: Movement disorders : official journal of the Movement Disorder Society20030601

Title: Effects of adrenal medulla graft on recovery of GABAergic and dopaminergic neuron deficits in mice: behavioural, pharmacological and immunohistochemical study.

Journal: Behavioural brain research20030318

Title: Decreased limbic vesicular monoamine transporter 2 in a genetic rat model of depression.

Journal: Brain research20030307

Title: Successful therapy of tardive dyskinesia in a 71-year-old woman with a combination of tetrabenazine, olanzapine and tiapride.

Journal: International journal of clinical practice20030301

Title: Gilles de la Tourette's syndrome.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques20030301

Title: Psychopharmacological effects of tianeptine analogous hetero[2,1] benzothiazepine derivatives.

Journal: Arzneimittel-Forschung20030101

Title: Classification and treatment of tardive syndromes.

Journal: The neurologist20030101

Title: Self-biting induced by activation of L-type calcium channels in mice: dopaminergic influences.

Journal: Developmental neuroscience20030101

Title: Non-synaptic release of [3H]noradrenaline in response to oxidative stress combined with mitochondrial dysfunction in rat hippocampal slices.

Journal: Neuroscience20030101

Title: Evaluation of the central properties of several Hypericum species from the Canary Islands.

Journal: Phytotherapy research : PTR20021201

Title: Elevated platelet vesicular monoamine transporter density in untreated patients diagnosed with major depression.

Journal: Psychiatry research20021115

Title: Methylphenidate redistributes vesicular monoamine transporter-2: role of dopamine receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20021001

Title: 1-(Benzofuran-2-yl)-2-(3,3,3-trifluoropropyl)aminopentane HCl, 3-F-BPAP, antagonizes the enhancer effect of (-)-BPAP in the shuttle box and leaves the effect of (-)-deprenyl unchanged.

Journal: Life sciences20020913

Title: Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice.

Journal: Journal of neuroendocrinology20020901

Title: Catastrophic reactions induced by tetrabenazine.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie20020901

Title: Increased platelet vesicular monoamine transporter density in adult schizophrenia patients.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20020801

Title: Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.

Journal: Pharmacology, biochemistry, and behavior20020701

Title: Effect of tetrabenazine on the striatal uptake of exogenous L-DOPA in vivo: a PET study in young and aged rhesus monkeys.

Journal: Synapse (New York, N.Y.)20020615

Title: Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20020601

Title: Human megakaryocytes cultured in vitro accumulate serotonin but not meta-iodobenzylguanidine whereas platelets concentrate both.

Journal: Experimental hematology20020601

Title: Norepinephrine triggers Ca2+-dependent exocytosis of 5-hydroxytryptamine from rat pinealocytes in culture.

Journal: Journal of neurochemistry20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Hemiballismus.

Journal: Irish medical journal20020401

Title: In vivo measures of dopaminergic radioligands in the rat brain: equilibrium infusion studies.

Journal: Synapse (New York, N.Y.)20020301

Title: Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity.

Journal: The Journal of pharmacology and experimental therapeutics20020301

Title: Phencyclidine increases vesicular dopamine uptake.

Journal: European journal of pharmacology20020301

Title: [Herpetic encephalitis in childhood: a diagnosis which should not be forgotten].

Journal: Revista de neurologia20020201

Title: Antidepressant effects of the methanol extract of several Hypericum species from the Canary Islands.

Journal: Journal of ethnopharmacology20020101

Title: Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys.

Journal: Pharmacology, biochemistry, and behavior20020101

Title: Tetrabenazine treatment for Huntington's disease-associated chorea.

Journal: Clinical neuropharmacology20020101

Title: Dual-[11C]tracer single-acquisition positron emission tomography studies.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20011201

Title: Characterization of high-affinity [3H]TBZOH binding to the human platelet vesicular monoamine transporter.

Journal: Life sciences20010928

Title: Vesicular neurotransmitter transporters in Huntington's disease: initial observations and comparison with traditional synaptic markers.

Journal: Synapse (New York, N.Y.)20010915

Title: Cocaine-induced increases in vesicular dopamine uptake: role of dopamine receptors.

Journal: The Journal of pharmacology and experimental therapeutics20010901

Title: Repetitive administration of tetrabenazine induces irreversible changes in locomotion and morphology of the substantia nigra in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie20010901

Title: Assessing the integrity of the dopamine system in Parkinson's disease: how best to do it?

Journal: Movement disorders : official journal of the Movement Disorder Society20010901

Title: Interactions of 1-methyl-4-phenylpyridinium and other compounds with P-glycoprotein: relevance to toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Journal: Brain research20010810

Title: Mutagenesis and derivatization of human vesicle monoamine transporter 2 (VMAT2) cysteines identifies transporter domains involved in tetrabenazine binding and substrate transport.

Journal: The Journal of biological chemistry20010720

Title: Structure-activity studies leading to (-)1-(benzofuran-2-yl)-2-propylaminopentane, ((-)BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain.

Journal: Bioorganic & medicinal chemistry20010501

Title: Meige syndrome secondary to basal ganglia injury: a potential cause of acute respiratory distress.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques20010501

Title: Hemichorea, moya-moya, and ulcerative colitis.

Journal: Movement disorders : official journal of the Movement Disorder Society20010501

Title: Vesicular monoamine transporters heterologously expressed in the yeast Saccharomyces cerevisiae display high-affinity tetrabenazine binding.

Journal: Biochimica et biophysica acta20010209

Title: [Spasmodic torticollis and vertebral hemangioma].

Journal: Revista de neurologia20010101

Title: Decreased densities of dopamine and serotonin transporters and of vesicular monoamine transporter 2 in severely kainic acid lesioned subregions of the striatum.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20010101

Title: Pharmacological options for the treatment of Tourette's disorder.

Journal: Drugs20010101

Title: Dyskinesia: L-dopa-induced and tardive dyskinesia.

Journal: Clinical neuropharmacology20010101

Title: Reversal of tetrabenazine induced depression by selective noradrenaline (norepinephrine) reuptake inhibition.

Journal: Journal of neurology, neurosurgery, and psychiatry19991001

Title: Modulation of gastrin processing by vesicular monoamine transporter type 1 (VMAT1) in rat gastrin cells.

Journal: The Journal of physiology19990601

Title: Levodopa therapy can ameliorate tetrabenazine-induced parkinsonism.

Journal: Movement disorders : official journal of the Movement Disorder Society19990101

Title: Peptide mapping of the [125I]Iodoazidoketanserin and [125I]2-N-[(3'-iodo-4'-azidophenyl)propionyl]tetrabenazine binding sites for the synaptic vesicle monoamine transporter.

Journal: The Journal of biological chemistry19971010

Title: Long-term effects of tetrabenazine in hyperkinetic movement disorders.

Journal: Neurology19970201

Title: Active transport of acetylcholine by the human vesicular acetylcholine transporter.

Journal: The Journal of biological chemistry19961101

Title: Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.

Journal: Proceedings of the National Academy of Sciences of the United States of America19960514

Title: [Drug-induced dystonia misinterpreted as hysteria].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke19960310

Title: Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile.

Journal: Brain research. Molecular brain research19940301

Title: Bilateral akinesia in drug-induced parkinsonism after a subthalamic lesion.

Journal: Movement disorders : official journal of the Movement Disorder Society19940101

Title: Functional identification and molecular cloning of a human brain vesicle monoamine transporter.

Journal: Journal of neurochemistry19931201

Title: Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

Journal: Proceedings of the National Academy of Sciences of the United States of America19921115

Title: Adenosine release in morphine-induced hypotension in rats.

Journal: General pharmacology19920101

Title: Coordinate and differential regulation of phenylethanolamine N-methyltransferase, tyrosine hydroxylase and proenkephalin mRNAs by neural and hormonal mechanisms in cultured bovine adrenal medullary cells.

Journal: Brain research19900305

Title: [Behavioral pharmacological properties of the novel antidepressant paroxetine, a selective 5-HT uptake inhibitor].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica19890901

Title: McN-5652: a highly potent inhibitor of serotonin uptake.

Journal: The Journal of pharmacology and experimental therapeutics19881201

Title: [Behavioral effects of quinupramine, a new tricyclic antidepressant].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica19880601

Title: Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias.

Journal: Neurology19880301

Title: Reserpine increases chromaffin cell enkephalin stores without a concomitant decrease in other proenkephalin-derived peptides.

Journal: Journal of neurochemistry19871101

Title: Iatrogenic parkinsonism in Huntington's chorea.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie19861201

Title: Pharmacology in vivo of the phenylindan derivative, Lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain.

Journal: Naunyn-Schmiedeberg's archives of pharmacology19850401

Title: Tetrabenazine induces acute dystonic reactions.

Journal: Annals of neurology19850201

Title: Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.

Journal: Journal of medicinal chemistry19840801

Title: Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys.

Journal: Psychopharmacology19840101

Title: Long-term treatment of tardive dyskinesia with presynaptically acting dopamine-depleting agents.

Journal: Advances in neurology19830101

Title: (+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 1. Synthesis and evaluation of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and analogues as potential antidepressant agents.

Journal: Journal of medicinal chemistry19820401

Title: Pharmacological evaluation of 2-(4-methylaminobutoxy)diphenylmethane hydrochloride (MCI-2016), a new psychotropic drug with antidepressant activity.

Journal: Arzneimittel-Forschung19810101

Title: [Behavioral pharmacology of mianserin hydrochloride, a new antidepressant (author's transl)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica19800901

Title: [Biochemical study of the animal model depression induced by tetrabenazine (author's transl)].

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica19800101

Title: The influence of cerebral 5-hydroxytryptamine on catalepsy induced by brain-amine depleting neuroleptics or by cholinomimetics.

Journal: British journal of pharmacology19791001

Title: 10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A novel class of potential neuroleptic agents.

Journal: Journal of medicinal chemistry19790601

Title: Pharmacological and biochemical studies with three metabolites of nomifensine.

Journal: Psychopharmacology19770131

Title: Tetrabenazine in the treatment of Huntington's chorea.

Journal: The Medical journal of Australia19760417

Title: [Behavior pharmacology of maprotiline, a new antidepressant].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica19751101

Title: Pharmacological analysis of a new anorexic substance: 5-hydroxy-5(4'-chlorophenyl)-2, 3-dihydro-5H-imidazo-(2, 1-a) isoindole (Mazindol).

Journal: Archives internationales de pharmacodynamie et de therapie19750401

Title: Spontaneous oral dyskinesia. Results of treatment with tetrabenazine, pimozide, or both.

Journal: Archives of neurology19741101

Title: A double-blind trial of tetrabenazine, thiopropazate, and placebo in patients with chorea.

Journal: Lancet (London, England)19740126

Title: Treatment of involuntary movement disorders with tetrabenazine.

Journal: Journal of neurology, neurosurgery, and psychiatry19720401

Title: Role of central dopaminergic receptors in manic response of cats to morphine.

Journal: Psychopharmacologia19720101

Title: Persistent phenothiazine dyskinesia treated with tetrabenazine.

Journal: British medical journal19711002

Title: Tetrabenazine for Huntington's chorea.

Journal: British medical journal19701003

Title: [Mechanism of inversion by demethylimipramine of motor depression induced by tetrabenazine].

Journal: Farmakologiia i toksikologiia19690101

Title: The effect of tetrabenazine in some hyperkinetic syndromes.

Journal: Acta neurologica Scandinavica19680101

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