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483-17-0,MFCD14702530
Catalog No.:AA00DD8Y

483-17-0 | cephaeline

Pack Size
Purity
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Price(USD)
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1mg
≥95%
in stock  
$252.00   $176.00
- +
5mg
95%
in stock  
$852.00   $597.00
- +
10mg
95%
in stock  
$1,490.00   $1,043.00
- +
25mg
95%
in stock  
$3,277.00   $2,294.00
- +
50mg
95%
in stock  
$5,852.00   $4,097.00
- +
100mg
95%
in stock  
$10,486.00   $7,340.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DD8Y
Chemical Name:
cephaeline
CAS Number:
483-17-0
Molecular Formula:
C28H38N2O4
Molecular Weight:
466.6123
MDL Number:
MFCD14702530
SMILES:
CC[C@H]1CN2CCc3c([C@@H]2C[C@@H]1C[C@H]1NCCc2c1cc(OC)c(c2)O)cc(c(c3)OC)OC
Properties
Computed Properties
 
Complexity:
664  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4.4  

Literature

Title: Angustinine--a new benzopyridoquinolizine alkaloid from Alangium lamarckii.

Journal: Natural product communications 20120901

Title: [Rapid detection of alkaloids in Ipecac by direct analysis in real time tandem mass spectrometry (DART-MS/MS)].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

Title: Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities.

Journal: Pharmacognosy reviews 20120101

Title: Inhibition of gastric H+, K(+)-ATPase activity by compounds from medicinal plants.

Journal: Natural product communications 20110901

Title: Molecular cloning of an O-methyltransferase from adventitious roots of Carapichea ipecacuanha.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.

Journal: Leukemia research 20100701

Title: Is a metabolic enzyme complex involved in the efficient and accurate control of Ipecac alkaloid biosynthesis in Psychotria ipecacuanha?

Journal: Plant signaling & behavior 20100701

Title: Molecular phylogeography of Carapichea ipecacuanha, an amphitropical shrub that occurs in the understory of both semideciduous and evergreen forests.

Journal: Molecular ecology 20100401

Title: Three new O-methyltransferases are sufficient for all O-methylation reactions of ipecac alkaloid biosynthesis in root culture of Psychotria ipecacuanha.

Journal: The Journal of biological chemistry 20100305

Title: Biochemistry and occurrence of o-demethylation in plant metabolism.

Journal: Frontiers in physiology 20100101

Title: Clonal diversity and conservation genetics of the medicinal plant Carapichea ipecacuanha (Rubiaceae).

Journal: Genetics and molecular biology 20100101

Title: The new beta-D-glucosidase in terpenoid-isoquinoline alkaloid biosynthesis in Psychotria ipecacuanha.

Journal: The Journal of biological chemistry 20081212

Title: Ipecacuanha: the South American vomiting root.

Journal: The journal of the Royal College of Physicians of Edinburgh 20081201

Title: Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).

Journal: Journal of natural products 20080301

Title: Transformation of ipecac (Cephaelis ipecacuanha) with Agrobacterium rhizogenes.

Journal: Planta medica 20031101

Title: Antiparasitic alkaloids from Psychotria klugii.

Journal: Journal of natural products 20030701

Title: Urinary excretion of ipecac alkaloids in human volunteers.

Journal: Veterinary and human toxicology 20021001

Title: Studies for the emetic mechanisms of ipecac syrup (TJN-119) and its active components in ferrets: involvement of 5-hydroxytryptamine receptors.

Journal: Japanese journal of pharmacology 20020601

Title: Absorption, distribution and excretion of 3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats.

Journal: European journal of drug metabolism and pharmacokinetics 20020101

Title: Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats.

Journal: European journal of drug metabolism and pharmacokinetics 20020101

Title: High-performance liquid chromatographic assay with fluorescence detection for the determination of cephaeline and emetine in human plasma and urine.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010615

Title: Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities.

Journal: Biological & pharmaceutical bulletin 20010601

Title: HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products.

Journal: Biochemical and biophysical research communications 19920529

Title: Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase.

Journal: The Journal of biological chemistry 19911215

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: N.P.Sahu, et al. Determination of emetine and cephaeline in Ipecac roots by high- performance liquid chromatography. Journal of Chromatography A. 1982 Apr; 238( 2):525-529.

Title: Yang S, et al. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 2018 Jun 5;4:31.

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