Home Amines 21561-09-1
21561-09-1,MFCD01815294
Catalog No.:AA007PVD

21561-09-1 | 4-Phenylamino-6,7-dimethoxyquinazoline

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25mg
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500mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007PVD
Chemical Name:
4-Phenylamino-6,7-dimethoxyquinazoline
CAS Number:
21561-09-1
Molecular Formula:
C16H15N3O2
Molecular Weight:
281.3092
MDL Number:
MFCD01815294
SMILES:
COc1cc2c(ncnc2cc1OC)Nc1ccccc1
Properties
Computed Properties
 
Complexity:
323  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.4  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.1371-1375

[2]JournalofMedicinalChemistry,2019,vol.62,p.2428-2446

[3]OrganicLetters,2019,vol.21,p.5111-5115

[4]BioorganicandMedicinalChemistry,2014,vol.22,p.1909-1915

[5]BioorganicandMedicinalChemistry,1996,vol.4,p.1203-1207

[6]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.2724-2729

[7]Molecules,2021,vol.26

100-52-7    21561-09-1   
6,7-dimethoxy-8-(hydroxyphenylmethyl)-4-phenylaminoquinazoline 

[1]Chapoulaud,V.Gautheron;Salliot;Ple;Turck;Queguiner[Tetrahedron,1999,vol.55,#17,p.5389-5404]

75-07-0    21561-09-1   
6,7-dimethoxy-8-(1-hydroxyethyl)-4-phenylaminoquinazoline 

[1]Chapoulaud,V.Gautheron;Salliot;Ple;Turck;Queguiner[Tetrahedron,1999,vol.55,#17,p.5389-5404]

[1]Gazit,Aviv;Chen,Jeffrey;Harald,App;McMahon,Gerald;Hirth,Peter;Chen,Irit;Levitzki,Alexander[BioorganicandMedicinalChemistry,1996,vol.4,#8,p.1203-1207]

[2]Bensinger,Dennis;Stubba,Daniel;Cremer,Anjali;Kohl,Vanessa;Waßmer,Theresa;Stuckert,Johanna;Engemann,Victoria;Stegmaier,Kimberly;Schmitz,Katja;Schmidt,Boris[JournalofMedicinalChemistry,2019,vol.62,#5,p.2428-2446]

Literature

Title: Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

Journal: Journal of medicinal chemistry 20120209

Title: Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Journal: Journal of medicinal chemistry 19960105

Title: Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.

Title: Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.

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Tags:21561-09-1 Molecular Formula|21561-09-1 MDL|21561-09-1 SMILES|21561-09-1 4-Phenylamino-6,7-dimethoxyquinazoline