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1033735-94-2,MFCD18251526
Catalog No.:AA008TDR

1033735-94-2 | GNE-493

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$29.00   $21.00
- +
5mg
98+%
in stock  
$74.00   $52.00
- +
10mg
98+%
in stock  
$111.00   $78.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TDR
Chemical Name:
GNE-493
CAS Number:
1033735-94-2
Molecular Formula:
C17H20N6O2S
Molecular Weight:
372.4447
MDL Number:
MFCD18251526
SMILES:
Nc1ncc(cn1)c1nc(N2CCOCC2)c2c(n1)cc(s2)C(O)(C)C
Properties
Computed Properties
 
Complexity:
484  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
0.7  

Downstream Synthesis Route

[1]Locationinpatent:experimentalpartSutherlin,DanielP.;Sampath,Deepak;Berry,Megan;Castanedo,Georgette;Chang,Zhigang;Chuckowree,Irina;Dotson,Jenna;Folkes,Adrian;Friedman,Lori;Goldsmith,Richard;Heffron,Tim;Lee,Leslie;Lesnick,John;Lewis,Cristina;Mathieu,Simon;Nonomiya,Jim;Olivero,Alan;Pang,Jodie;Prior,WeiWei;Salphati,Laurent;Sideris,Steve;Tian,Qingping;Tsui,Vickie;Wan,NanChi;Wang,Shumei;Wiesmann,Christian;Wong,Susan;Zhu,Bing-Yan[JournalofMedicinalChemistry,2010,vol.53,#3,p.1086-1097]

[1]Locationinpatent:experimentalpartSutherlin,DanielP.;Sampath,Deepak;Berry,Megan;Castanedo,Georgette;Chang,Zhigang;Chuckowree,Irina;Dotson,Jenna;Folkes,Adrian;Friedman,Lori;Goldsmith,Richard;Heffron,Tim;Lee,Leslie;Lesnick,John;Lewis,Cristina;Mathieu,Simon;Nonomiya,Jim;Olivero,Alan;Pang,Jodie;Prior,WeiWei;Salphati,Laurent;Sideris,Steve;Tian,Qingping;Tsui,Vickie;Wan,NanChi;Wang,Shumei;Wiesmann,Christian;Wong,Susan;Zhu,Bing-Yan[JournalofMedicinalChemistry,2010,vol.53,#3,p.1086-1097]

Literature

Title: Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform.

Journal: Journal of medicinal chemistry 20111124

Title: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer.

Journal: Journal of medicinal chemistry 20100211

Title: Sutherlin DP, et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97.

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SDS
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Tags:1033735-94-2 Molecular Formula|1033735-94-2 MDL|1033735-94-2 SMILES|1033735-94-2 GNE-493
Catalog No.: AA008TDR
1033735-94-2,MFCD18251526
1033735-94-2 | GNE-493
Pack Size： 1mg
Purity： 98+%
in stock
$29.00 $21.00
Pack Size： 5mg
Purity： 98+%
in stock
$74.00 $52.00
Pack Size： 10mg
Purity： 98+%
in stock
$111.00 $78.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA008TDR
Chemical Name: GNE-493
CAS Number: 1033735-94-2
Molecular Formula: C17H20N6O2S
Molecular Weight: 372.4447
MDL Number: MFCD18251526
SMILES: Nc1ncc(cn1)c1nc(N2CCOCC2)c2c(n1)cc(s2)C(O)(C)C
Properties
Complexity: 484  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 3  
XLogP3: 0.7  
Downstream Synthesis Route
402960-38-7    1033743-25-7    1033735-94-2 

[1]Locationinpatent:experimentalpartSutherlin,DanielP.;Sampath,Deepak;Berry,Megan;Castanedo,Georgette;Chang,Zhigang;Chuckowree,Irina;Dotson,Jenna;Folkes,Adrian;Friedman,Lori;Goldsmith,Richard;Heffron,Tim;Lee,Leslie;Lesnick,John;Lewis,Cristina;Mathieu,Simon;Nonomiya,Jim;Olivero,Alan;Pang,Jodie;Prior,WeiWei;Salphati,Laurent;Sideris,Steve;Tian,Qingping;Tsui,Vickie;Wan,NanChi;Wang,Shumei;Wiesmann,Christian;Wong,Susan;Zhu,Bing-Yan[JournalofMedicinalChemistry,2010,vol.53,#3,p.1086-1097]

1033735-94-2    1204033-41-9 

[1]Locationinpatent:experimentalpartSutherlin,DanielP.;Sampath,Deepak;Berry,Megan;Castanedo,Georgette;Chang,Zhigang;Chuckowree,Irina;Dotson,Jenna;Folkes,Adrian;Friedman,Lori;Goldsmith,Richard;Heffron,Tim;Lee,Leslie;Lesnick,John;Lewis,Cristina;Mathieu,Simon;Nonomiya,Jim;Olivero,Alan;Pang,Jodie;Prior,WeiWei;Salphati,Laurent;Sideris,Steve;Tian,Qingping;Tsui,Vickie;Wan,NanChi;Wang,Shumei;Wiesmann,Christian;Wong,Susan;Zhu,Bing-Yan[JournalofMedicinalChemistry,2010,vol.53,#3,p.1086-1097]

Literature fold

Title: Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform.

Journal: Journal of medicinal chemistry20111124

Title: Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer.

Journal: Journal of medicinal chemistry20100211

Title: Sutherlin DP, et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97.

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