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1394076-92-6,MFCD28900677
Catalog No.:AA009CFA

1394076-92-6 | GNE-317

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Purity
Availability
Price(USD)
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1mg
98%
in stock  
$24.00   $17.00
- +
5mg
≥98%
in stock  
$56.00   $39.00
- +
10mg
98%
in stock  
$87.00   $61.00
- +
50mg
98%
in stock  
$249.00   $174.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CFA
Chemical Name:
GNE-317
CAS Number:
1394076-92-6
Molecular Formula:
C19H22N6O3S
Molecular Weight:
414.4814
MDL Number:
MFCD28900677
SMILES:
COC1(COC1)c1sc2c(c1C)nc(nc2N1CCOCC1)c1cnc(nc1)N
Properties
Computed Properties
 
Complexity:
570  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
0.5  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2012,vol.55,p.8007-8020,14

[1]Heffron,TimothyP.;Salphati,Laurent;Alicke,Bruno;Cheong,Jonathan;Dotson,Jennafer;Edgar,Kyle;Goldsmith,Richard;Gould,StephenE.;Lee,LeslieB.;Lesnick,JohnD.;Lewis,Cristina;Ndubaku,Chudi;Nonomiya,Jim;Olivero,AlanG.;Pang,Jodie;Plise,EmileG.;Sideris,Steve;Trapp,Sean;Wallin,Jeffrey;Wang,Lan;Zhang,Xiaolin[JournalofMedicinalChemistry,2012,vol.55,#18,p.8007-8020,14]

[1]Heffron,TimothyP.;Salphati,Laurent;Alicke,Bruno;Cheong,Jonathan;Dotson,Jennafer;Edgar,Kyle;Goldsmith,Richard;Gould,StephenE.;Lee,LeslieB.;Lesnick,JohnD.;Lewis,Cristina;Ndubaku,Chudi;Nonomiya,Jim;Olivero,AlanG.;Pang,Jodie;Plise,EmileG.;Sideris,Steve;Trapp,Sean;Wallin,Jeffrey;Wang,Lan;Zhang,Xiaolin[JournalofMedicinalChemistry,2012,vol.55,#18,p.8007-8020,14]

Literature

Title: Salphati L, et al. Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging. Drug Metab Dispos. 2014 Jul;42(7):1110-6.

Title: Becker CM, et al. Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma. Neuro Oncol. 2015 Sep;17(9):1210-9.

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SDS
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