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Home Amines 1211443-80-9
1211443-80-9,MFCD28167745
Catalog No.:AA008TEK

1211443-80-9 | 7-Cyclopentyl-n,n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$85.00   $59.00
- +
25mg
98%
in stock  
$148.00   $104.00
- +
100mg
98%
in stock  
$402.00   $282.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TEK
Chemical Name:
7-Cyclopentyl-n,n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
CAS Number:
1211443-80-9
Molecular Formula:
C23H31ClN8O
Molecular Weight:
470.9982
MDL Number:
MFCD28167745
SMILES:
CN(C(=O)c1cc2c(n1C1CCCC1)nc(nc2)Nc1ccc(cn1)N1CCNCC1)C.Cl
Properties
Computed Properties
 
Complexity:
636  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  

Downstream Synthesis Route

[1]Patent:WO2010/20675,2010,A1.Locationinpatent:Page/Pagecolumn66;67

[1]Patent:WO2010/20675,2010,A1.Locationinpatent:Page/Pagecolumn70;71

[1]Patent:EP3434676,2019,A1.Locationinpatent:Paragraph0141;0142

Literature

Title: VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

Title: Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

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SDS
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Tags:1211443-80-9 Molecular Formula|1211443-80-9 MDL|1211443-80-9 SMILES|1211443-80-9 7-Cyclopentyl-n,n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride