+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
1033805-22-9,MFCD18251583
Catalog No.:AA008TEQ

1033805-22-9 | Lx1606

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
1 week  
$56.00   $39.00
- +
5mg
98+%
1 week  
$94.00   $66.00
- +
10mg
98+%
1 week  
$124.00   $87.00
- +
25mg
98+%
1 week  
$162.00   $114.00
- +
50mg
98+%
1 week  
$255.00   $179.00
- +
100mg
98+%
1 week  
$378.00   $265.00
- +
250mg
98+%
1 week  
$566.00   $396.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TEQ
Chemical Name:
Lx1606
CAS Number:
1033805-22-9
Molecular Formula:
C27H26ClF3N6O3
Molecular Weight:
574.9819
MDL Number:
MFCD18251583
SMILES:
CCOC(=O)[C@H](Cc1ccc(cc1)c1cc(nc(n1)N)O[C@@H](C(F)(F)F)c1ccc(cc1n1ccc(n1)C)Cl)N
Properties
Computed Properties
 
Complexity:
821  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
5.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GTCRLLC-US2008/153852,2008,A1Locationinpatent:Page/Pagecolumn19

[1]CurrentPatentAssignee:GTCRLLC-US2008/153852,2008,A1Locationinpatent:Page/Pagecolumn19

[2]CurrentPatentAssignee:LEXICONPHARMACEUTICALSINC-CN104045626,2017,BLocationinpatent:Paragraph0234;0235;02360237

[1]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn11

[1]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn11

[2]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn12

[3]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn7

110-15-6    1033805-22-9   
(S)-ethyl2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoatesuccinate 

[1]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn8

Literature

Title: Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20170101

Title: Telotristat ethyl: a new option for the management of carcinoid syndrome.

Journal: Expert opinion on pharmacotherapy 20161201

Title: Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20150915

Title: Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide.

Journal: Endocrine-related cancer 20141001

Title: Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

Journal: Gut 20140601

Title: Attractants for synanthropic flies. Identification of attractants and coattractants for Hippelates eye gnats (Diptera: Chloropidae).

Journal: Journal of agricultural and food chemistry 19760101

Title: Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.

Title: Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 1033805-22-9
1137608-69-5

1137608-69-5

 1033805-28-5

1033805-28-5

 1033805-27-4

1033805-27-4

 1125828-44-5

1125828-44-5

 1374745-52-4

1374745-52-4
Building Blocks
More >
Tags:1033805-22-9 Molecular Formula|1033805-22-9 MDL|1033805-22-9 SMILES|1033805-22-9 Lx1606
Catalog No.: AA008TEQ
1033805-22-9,MFCD18251583
1033805-22-9 | Lx1606
Pack Size： 1mg
Purity： 98+%
1 week
$56.00 $39.00
Pack Size： 5mg
Purity： 98+%
1 week
$94.00 $66.00
Pack Size： 10mg
Purity： 98+%
1 week
$124.00 $87.00
Pack Size： 25mg
Purity： 98+%
1 week
$162.00 $114.00
Pack Size： 50mg
Purity： 98+%
1 week
$255.00 $179.00
Pack Size： 100mg
Purity： 98+%
1 week
$378.00 $265.00
Pack Size： 250mg
Purity： 98+%
1 week
$566.00 $396.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008TEQ
Chemical Name: Lx1606
CAS Number: 1033805-22-9
Molecular Formula: C27H26ClF3N6O3
Molecular Weight: 574.9819
MDL Number: MFCD18251583
SMILES: CCOC(=O)[C@H](Cc1ccc(cc1)c1cc(nc(n1)N)O[C@@H](C(F)(F)F)c1ccc(cc1n1ccc(n1)C)Cl)N
Properties
Complexity: 821  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Heavy Atom Count: 40  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 10  
XLogP3: 5.1  
Downstream Synthesis Route
67-56-1    1033805-28-5    1033805-22-9 

[1]CurrentPatentAssignee:GTCRLLC-US2008/153852,2008,A1Locationinpatent:Page/Pagecolumn19

1033805-22-9    1033805-28-5 

[1]CurrentPatentAssignee:GTCRLLC-US2008/153852,2008,A1Locationinpatent:Page/Pagecolumn19

[2]CurrentPatentAssignee:LEXICONPHARMACEUTICALSINC-CN104045626,2017,BLocationinpatent:Paragraph0234;0235;02360237

64-17-5    1125828-44-5    1033805-22-9 

[1]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn11

1125828-44-5    1033805-22-9 

[1]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn11

[2]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn12

[3]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn7

110-15-6    1033805-22-9   
(S)-ethyl2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoatesuccinate 

[1]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn8

Literature fold

Title: Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20170101

Title: Telotristat ethyl: a new option for the management of carcinoid syndrome.

Journal: Expert opinion on pharmacotherapy20161201

Title: Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.

Journal: American journal of physiology. Gastrointestinal and liver physiology20150915

Title: Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide.

Journal: Endocrine-related cancer20141001

Title: Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

Journal: Gut20140601

Title: Attractants for synanthropic flies. Identification of attractants and coattractants for Hippelates eye gnats (Diptera: Chloropidae).

Journal: Journal of agricultural and food chemistry19760101

Title: Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.

Title: Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

Related Products of of 1033805-22-9
1137608-69-5
1137608-69-5
1033805-28-5
1033805-28-5
1033805-27-4
1033805-27-4
1125828-44-5
1125828-44-5
1374745-52-4
1374745-52-4
Building Blocks More >
1203494-49-8
1203494-49-8
DASA-58
AA008TIW | MFCD29472280
1187830-47-2
1187830-47-2
4,5,6,7-Tetrahydro-1h-pyrazolo[4,3-b]pyridine hydrochloride
AA008TN1 | MFCD11846201
106535-28-8
106535-28-8
1-(1-Methyl-1H-1,2,4-triazol-5-yl)ethanone
AA008TV7 | MFCD09864474
1071433-06-1
1071433-06-1
2-Methyl-2h-indazole-4-carboxylic acid
AA008U4G | MFCD15071443
106134-16-1
106134-16-1
3-Bromophenylglyoxal hydrate
AA008UDL | MFCD08448029
1204298-55-4
1204298-55-4
Piperazin-1-yl(quinoxalin-6-yl)methanone hydrochloride
AA008UNX | MFCD13619874
73890-74-1
73890-74-1
2-Penten-1-ol, 2-methyl-5-[(1R,2R,4S)-2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl]-, (2E)-rel-
AA01X5CA | MFCD00046301
1177349-02-8
1177349-02-8
3-(4-Bromo-1h-pyrazol-1-yl)propanamide
AA008V55 | MFCD12030835
1003-34-5
1003-34-5
5-Chloro-2,4-dihydro-3h-1,2,4-triazol-3-one
AA008VBX | MFCD14702886
1199215-93-4
1199215-93-4
3-Cyclobutyl-1h-1,2,4-triazole
AA008VGH | MFCD13188588
Submit
© 2017 AA BLOCKS, INC. All rights reserved.