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Home Other Building Blocks 1033805-22-9
1033805-22-9,MFCD18251583
Catalog No.:AA008TEQ

1033805-22-9 | Lx1606

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
1 week  
$56.00   $39.00
- +
5mg
98+%
1 week  
$94.00   $66.00
- +
10mg
98+%
1 week  
$124.00   $87.00
- +
25mg
98+%
1 week  
$162.00   $114.00
- +
50mg
98+%
1 week  
$255.00   $179.00
- +
100mg
98+%
1 week  
$378.00   $265.00
- +
250mg
98+%
1 week  
$566.00   $396.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TEQ
Chemical Name:
Lx1606
CAS Number:
1033805-22-9
Molecular Formula:
C27H26ClF3N6O3
Molecular Weight:
574.9819
MDL Number:
MFCD18251583
SMILES:
CCOC(=O)[C@H](Cc1ccc(cc1)c1cc(nc(n1)N)O[C@@H](C(F)(F)F)c1ccc(cc1n1ccc(n1)C)Cl)N
Properties
Computed Properties
 
Complexity:
821  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
5.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GTCRLLC-US2008/153852,2008,A1Locationinpatent:Page/Pagecolumn19

[1]CurrentPatentAssignee:GTCRLLC-US2008/153852,2008,A1Locationinpatent:Page/Pagecolumn19

[2]CurrentPatentAssignee:LEXICONPHARMACEUTICALSINC-CN104045626,2017,BLocationinpatent:Paragraph0234;0235;02360237

[1]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn11

[1]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn11

[2]CurrentPatentAssignee:GTCRLLC-US2009/62540,2009,A1Locationinpatent:Page/Pagecolumn12

[3]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn7

110-15-6    1033805-22-9   
(S)-ethyl2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoatesuccinate 

[1]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn8

Literature

Title: Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20170101

Title: Telotristat ethyl: a new option for the management of carcinoid syndrome.

Journal: Expert opinion on pharmacotherapy 20161201

Title: Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20150915

Title: Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide.

Journal: Endocrine-related cancer 20141001

Title: Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

Journal: Gut 20140601

Title: Attractants for synanthropic flies. Identification of attractants and coattractants for Hippelates eye gnats (Diptera: Chloropidae).

Journal: Journal of agricultural and food chemistry 19760101

Title: Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.

Title: Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

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SDS
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