Home Other Building Blocks 1137608-69-5
1137608-69-5,MFCD22741520
Catalog No.:AA008TER

1137608-69-5 | Telotristat Etiprate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$238.00   $166.00
- +
25mg
≥98%
in stock  
$490.00   $343.00
- +
50mg
≥99%
in stock  
$515.00   $360.00
- +
250mg
≥99%
in stock  
$2,116.00   $1,482.00
- +
1g
≥99%
in stock  
$7,465.00   $5,225.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TER
Chemical Name:
Telotristat Etiprate
CAS Number:
1137608-69-5
Molecular Formula:
C36H35ClF3N7O6
Molecular Weight:
754.1546
MDL Number:
MFCD22741520
SMILES:
OC(=O)CNC(=O)c1ccccc1.CCOC(=O)[C@H](Cc1ccc(cc1)c1cc(nc(n1)N)O[C@H](c1ccc(cc1n1ccc(n1)C)Cl)C(F)(F)F)N
Properties
Computed Properties
 
Complexity:
1020  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
53  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
13  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn8

[1]CurrentPatentAssignee:GTCRLLC-US2009/88447,2009,A1Locationinpatent:Page/Pagecolumn8

Literature

Title: Telotristat ethyl: a new option for the management of carcinoid syndrome.

Journal: Expert opinion on pharmacotherapy 20161201

Title: Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20150915

Title: Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide.

Journal: Endocrine-related cancer 20141001

Title: Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

Journal: Gut 20140601

Title: Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.

Title: Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

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SDS
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