+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
1010085-13-8,MFCD22124479
Catalog No.:AA008TFD

1010085-13-8 | MK-5108

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$38.00   $27.00
- +
5mg
98%
in stock  
$84.00   $59.00
- +
10mg
98%
in stock  
$154.00   $108.00
- +
100mg
95%
in stock  
$1,075.00 $753.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TFD
Chemical Name:
MK-5108
CAS Number:
1010085-13-8
Molecular Formula:
C22H21ClFN3O3S
Molecular Weight:
461.9368
MDL Number:
MFCD22124479
SMILES:
OC(=O)C1(CCC(CC1)Oc1cccc(c1F)Cl)Cc1cccc(n1)Nc1nccs1
Properties
Computed Properties
 
Complexity:
611  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
5.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:MERCK&COINC-US2008/58347,2008,A1Locationinpatent:Page/Pagecolumn37

[1]CurrentPatentAssignee:EUBULUSBIOTHERAPEUTICS-CN111018857,2020,ALocationinpatent:Paragraph0217;0245-0247;0250

[1]CurrentPatentAssignee:EUBULUSBIOTHERAPEUTICS-CN111018857,2020,ALocationinpatent:Paragraph0217;0236-0238;0241

Literature

Title: Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.

Journal: Journal of molecular biology 20170217

Title: A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120615

Title: Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

Journal: Cancer research 20110601

Title: Aurora kinase inhibitors as anti-cancer therapy.

Journal: Anti-cancer drugs 20100401

Title: MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.

Journal: Molecular cancer therapeutics 20100101

Title: Shimomura T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther. 2010 Jan;9(1):157-66.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 1010085-13-8
Building Blocks
More >
Tags:1010085-13-8 Molecular Formula|1010085-13-8 MDL|1010085-13-8 SMILES|1010085-13-8 MK-5108
Catalog No.: AA008TFD
1010085-13-8,MFCD22124479
1010085-13-8 | MK-5108
Pack Size： 1mg
Purity： 98%
in stock
$38.00 $27.00
Pack Size： 5mg
Purity： 98%
in stock
$84.00 $59.00
Pack Size： 10mg
Purity： 98%
in stock
$154.00 $108.00
Pack Size： 100mg
Purity： 95%
in stock
$1,075.00 $753.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008TFD
Chemical Name: MK-5108
CAS Number: 1010085-13-8
Molecular Formula: C22H21ClFN3O3S
Molecular Weight: 461.9368
MDL Number: MFCD22124479
SMILES: OC(=O)C1(CCC(CC1)Oc1cccc(c1F)Cl)Cc1cccc(n1)Nc1nccs1
Properties
Complexity: 611  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 7  
XLogP3: 5.4  
Downstream Synthesis Route
1010085-11-6    1010085-13-8 

[1]CurrentPatentAssignee:MERCK&COINC-US2008/58347,2008,A1Locationinpatent:Page/Pagecolumn37

1010085-13-8    2361119-88-0    2415738-27-9 

[1]CurrentPatentAssignee:EUBULUSBIOTHERAPEUTICS-CN111018857,2020,ALocationinpatent:Paragraph0217;0245-0247;0250

1010085-13-8    1946779-33-4    2415738-16-6 

[1]CurrentPatentAssignee:EUBULUSBIOTHERAPEUTICS-CN111018857,2020,ALocationinpatent:Paragraph0217;0236-0238;0241

Literature fold

Title: Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.

Journal: Journal of molecular biology20170217

Title: A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20120615

Title: Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

Journal: Cancer research20110601

Title: Aurora kinase inhibitors as anti-cancer therapy.

Journal: Anti-cancer drugs20100401

Title: MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.

Journal: Molecular cancer therapeutics20100101

Title: Shimomura T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther. 2010 Jan;9(1):157-66.

Related Products of of 1010085-13-8
Building Blocks More >
1202055-32-0
1202055-32-0
NMS-P715
AA008TK0 | MFCD19443684
1187830-77-8
1187830-77-8
5,6,7,8-Tetrahydro-4-methoxypyrido[3,4-d]pyrimidine hcl
AA008TO5 | MFCD11846181
1060816-19-4
1060816-19-4
2-bromo-4-phenyl-1,3-oxazole
AA008TXY | MFCD12828097
120081-14-3
120081-14-3
Goralatide
AA008U6J | MFCD00076849
107485-43-8
107485-43-8
2-Chloro-6-methoxybenzamide
AA008UFE | MFCD11846167
112758-89-1
112758-89-1
1-Phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
AA008UQ2 | MFCD00297430
1042640-05-0
1042640-05-0
1-(Pyrrolidin-1-ylsulfonyl)piperidine-3-carboxylic acid
AA008V0Q | MFCD11171650
1199215-88-7
1199215-88-7
3-Chloro-5-(trifluoromethyl)-1h-1,2,4-triazole
AA008V67 | MFCD13248683
1177358-72-3
1177358-72-3
2-Methyl-2-(1H-pyrazol-1-yl)propan-1-ol
AA008VCG | MFCD11505285
110822-97-4
110822-97-4
2-(4H-1,2,4-Triazol-4-yl)acetic acid
AA008VHP | MFCD03093050
Submit
© 2017 AA BLOCKS, INC. All rights reserved.