Home Other Building Blocks 1010085-13-8
1010085-13-8,MFCD22124479
Catalog No.:AA008TFD

1010085-13-8 | MK-5108

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$38.00   $27.00
- +
5mg
98%
in stock  
$84.00   $59.00
- +
10mg
98%
in stock  
$154.00   $108.00
- +
100mg
95%
in stock  
$1,075.00   $753.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TFD
Chemical Name:
MK-5108
CAS Number:
1010085-13-8
Molecular Formula:
C22H21ClFN3O3S
Molecular Weight:
461.9368
MDL Number:
MFCD22124479
SMILES:
OC(=O)C1(CCC(CC1)Oc1cccc(c1F)Cl)Cc1cccc(n1)Nc1nccs1
Properties
Computed Properties
 
Complexity:
611  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
5.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:MERCK&COINC-US2008/58347,2008,A1Locationinpatent:Page/Pagecolumn37

[1]CurrentPatentAssignee:EUBULUSBIOTHERAPEUTICS-CN111018857,2020,ALocationinpatent:Paragraph0217;0245-0247;0250

[1]CurrentPatentAssignee:EUBULUSBIOTHERAPEUTICS-CN111018857,2020,ALocationinpatent:Paragraph0217;0236-0238;0241

Literature

Title: Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.

Journal: Journal of molecular biology 20170217

Title: A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120615

Title: Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

Journal: Cancer research 20110601

Title: Aurora kinase inhibitors as anti-cancer therapy.

Journal: Anti-cancer drugs 20100401

Title: MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.

Journal: Molecular cancer therapeutics 20100101

Title: Shimomura T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther. 2010 Jan;9(1):157-66.

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SDS
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Tags:1010085-13-8 Molecular Formula|1010085-13-8 MDL|1010085-13-8 SMILES|1010085-13-8 MK-5108