Home Indole and Oxindoles 137592-45-1
137592-45-1,MFCD00236430
Catalog No.:AA009AQ2

137592-45-1 | BISINDOLYLMALEIMIDE II

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1mg
≥97% (isomer mixture)
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$82.00   $57.00
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5mg
≥97% (isomer mixture)
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$246.00   $172.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA009AQ2
Chemical Name:
BISINDOLYLMALEIMIDE II
CAS Number:
137592-45-1
Molecular Formula:
C27H26N4O2
Molecular Weight:
438.5209
MDL Number:
MFCD00236430
SMILES:
CN1CCCC1CCn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
825  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.7  

Literature

Title: Phospholipase C-δ(1) regulates interleukin-1β and tumor necrosis factor-α mRNA expression.

Journal: Experimental cell research 20121001

Title: Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons.

Journal: The Journal of physiology 20120101

Title: Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100901

Title: Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.

Journal: Journal of medicinal chemistry 20090625

Title: Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090101

Title: Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether.

Journal: Bioorganic & medicinal chemistry letters 20080401

Title: Signalling pathways involved in the control of sperm cell volume.

Journal: Reproduction (Cambridge, England) 20070101

Title: Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.

Journal: Journal of medicinal chemistry 20061214

Title: The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.

Journal: The Journal of biological chemistry 20040528

Title: Phospholipase C and protein kinase C involvement in mouse embryonic stem-cell proliferation and apoptosis.

Journal: Reproduction (Cambridge, England) 20030701

Title: Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.

Journal: Molecular pharmacology 20020601

Title: Protein kinase C involvement in proliferation and survival of breast cancer cells.

Journal: Folia histochemica et cytobiologica 20020101

Title: Role of protein kinase Cdelta in transmitting hypoxia signal to HSF and HIF-1.

Journal: Journal of cellular physiology 20010801

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Tags:137592-45-1 Molecular Formula|137592-45-1 MDL|137592-45-1 SMILES|137592-45-1 BISINDOLYLMALEIMIDE II