133053-19-7,MFCD04040031
Catalog No.:AA0011IH

133053-19-7 | Go 6983

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$209.00   $146.00
- +
50mg
95%
in stock  
$252.00   $177.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0011IH
Chemical Name:
Go 6983
CAS Number:
133053-19-7
Molecular Formula:
C26H26N4O3
Molecular Weight:
442.5096
MDL Number:
MFCD04040031
SMILES:
COc1ccc2c(c1)c(cn2CCCN(C)C)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2
Properties
Properties
 
BP:
709°C at 760 mmHg  
Form:
Solid  
Solubility:
DMSO: 20 mg/mL, clear, red  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
796  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.1  

Downstream Synthesis Route
1064777-83-8   
CASUnavailable 
  133053-19-7 

[1]CurrentPatentAssignee:GYEONGSANGNATIONALUNIVERSITY-WO2008/117935,2008,A1Locationinpatent:Page/Pagecolumn32

879-37-8   
GO6983 

[1]Patent:WO2008/117935,2008,A1

[1]CurrentPatentAssignee:GYEONGSANGNATIONALUNIVERSITY-WO2008/117935,2008,A1

[1]CurrentPatentAssignee:GYEONGSANGNATIONALUNIVERSITY-WO2008/117935,2008,A1

Literature

Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure influence the expression of glutamate transporter GLT-1 in C6 glioma cells via the Ca(2+) /protein kinase C pathway.

Journal: Journal of applied toxicology : JAT 20161101

Title: p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).

Journal: The Journal of biological chemistry 20160318

Title: Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.

Journal: The Biochemical journal 20130901

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels.

Journal: The Biochemical journal 20121115

Title: Novel regulation of protein kinase C-η.

Journal: Biochemical and biophysical research communications 20120907

Title: Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120901

Title: Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.

Journal: Investigative ophthalmology & visual science 20120501

Title: Interferon-γ-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway.

Journal: Immunobiology 20120401

Title: Regulation and rate limiting mechanisms of Ca2+ ATPase (SERCA2) expression in cardiac myocytes.

Journal: Molecular and cellular biochemistry 20120201

Title: The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.

Journal: Cellular signalling 20120101

Title: Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells.

Journal: Cellular signalling 20120101

Title: Reduced calcium current density in female versus male mouse adrenal chromaffin cells in situ.

Journal: Cell calcium 20120101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Inhibition of protein kinase C promotes differentiation of neuroblastoma × glioma NG108-15 hybrid cells.

Journal: The European journal of neuroscience 20111001

Title: Protective effect of 4,4'-diaminodiphenylsulfone against paraquat-induced mouse lung injury.

Journal: Experimental & molecular medicine 20110930

Title: Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha.

Journal: Cellular signalling 20110901

Title: Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.

Journal: The Journal of biological chemistry 20110826

Title: Protein kinase D regulates the adiponectin gene expression through phosphorylation of AP-2: a common pathway to the ABCA1 gene regulation.

Journal: Atherosclerosis 20110501

Title: Proteomic analysis of cPKCβII-interacting proteins involved in HPC-induced neuroprotection against cerebral ischemia of mice.

Journal: Journal of neurochemistry 20110401

Title: PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.

Journal: BMB reports 20110201

Title: Differential roles of phosphorylated AMPA receptor GluR1 subunits at Serine-831 and Serine-845 sites in spinal cord dorsal horn in a rat model of post-operative pain.

Journal: Neurochemical research 20110101

Title: Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.

Journal: British journal of pharmacology 20100801

Title: Rapid activation of dormant presynaptic terminals by phorbol esters.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100728

Title: SSeCKS promote beta-amyloid-induced PC12 cells neurotoxicity by up-regulating tau phosphorylation in Alzheimer's disease.

Journal: Molecular and cellular biochemistry 20100701

Title: Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.

Journal: The Prostate 20100701

Title: [Effect of PKC signalling pathway and aldose reductase on expression of fibronectin induced by transforming growth factor-β1 in human mesangial cells].

Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology 20100601

Title: Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2.

Journal: Cellular signalling 20091101

Title: Anti-cancer activity and mechanistic features of a NK cell activating molecule.

Journal: Cancer immunology, immunotherapy : CII 20091001

Title: Establishment of screening system toward discovery of kinase inhibitors using label-free on-chip phosphorylation assays.

Journal: Bio Systems 20090901

Title: Involvement of protein kinase C in IL-1beta-induced expression of cyclooxygenase-2 in human gingival fibroblasts.

Journal: Journal of oral science 20090901

Title: Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake.

Journal: American journal of physiology. Endocrinology and metabolism 20090801

Title: Cortical F-actin, the exocytic mode, and neuropeptide release in mouse chromaffin cells is regulated by myristoylated alanine-rich C-kinase substrate and myosin II.

Journal: Molecular biology of the cell 20090701

Title: Low-power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway.

Journal: Journal of cellular physiology 20090601

Title: Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.

Journal: The Journal of biological chemistry 20090515

Title: Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation.

Journal: Investigative ophthalmology & visual science 20090201

Title: Phosphatidylethanol mediates its effects on the vascular endothelial growth factor via HDL receptor in endothelial cells.

Journal: Alcoholism, clinical and experimental research 20090201

Title: Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090201

Title: Leptin stimulated C-reactive protein production by human coronary artery endothelial cells.

Journal: Journal of vascular research 20090101

Title: Low-power laser irradiation activates Src tyrosine kinase through reactive oxygen species-mediated signaling pathway.

Journal: Journal of cellular physiology 20081101

Title: PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.

Journal: International journal of cancer 20080815

Title: Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C.

Journal: Cellular signalling 20080701

Title: Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.

Journal: Bioorganic & medicinal chemistry 20080415

Title: Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells.

Journal: Regulatory peptides 20080410

Title: Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.

Journal: Experimental and molecular pathology 20080201

Title: nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells.

Journal: American journal of physiology. Cell physiology 20071101

Title: Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20071001

Title: Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.

Journal: American journal of physiology. Lung cellular and molecular physiology 20070801

Title: Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070501

Title: Regulation of anion exchanger Slc26a6 by protein kinase C.

Journal: American journal of physiology. Cell physiology 20070401

Title: Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis.

Journal: Journal of neurochemistry 20070101

Title: Beta(2)-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP.

Journal: Diabetologia 20070101

Title: Lactoferrin stimulates erythrocyte Na+/K+ -adenosine triphosphatase: effect of some modulators of membrane phosphorylation.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

Title: Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060915

Title: Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway.

Journal: Biochemical and biophysical research communications 20060217

Title: Effect of topiramate and dBcAMP on expression of the glutamate transporters GLAST and GLT-1 in astrocytes cultured separately, or together with neurons.

Journal: Neurochemistry international 20060101

Title: Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle.

Journal: Lung 20060101

Title: Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes.

Journal: The Journal of biological chemistry 20050729

Title: Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor.

Journal: The Journal of biological chemistry 20050513

Title: Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor.

Journal: The Journal of biological chemistry 20050211

Title: Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983).

Journal: Molecular pharmacology 20050201

Title: alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway.

Journal: Endocrinology 20050201

Title: Metabolic arrest and its regulation in anoxic eel hepatocytes.

Journal: Physiological and biochemical zoology : PBZ 20050101

Title: Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.

Journal: Cardiovascular drug reviews 20050101

Title: A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

Title: IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.

Journal: Microbes and infection 20041101

Title: Possible involvement of protein kinase C activation in differentiation of human umbilical vein endothelium-derived cell into smooth muscle-like cell.

Journal: Biology of the cell 20040901

Title: Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes.

Journal: Cardiovascular research 20040815

Title: Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation.

Journal: Molecules and cells 20040630

Title: PfPKB, a novel protein kinase B-like enzyme from Plasmodium falciparum: I. Identification, characterization, and possible role in parasite development.

Journal: The Journal of biological chemistry 20040604

Title: PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice.

Journal: European journal of pharmacology 20040525

Title: Mechanism of human urotensin II-induced contraction in rat aorta.

Journal: Journal of pharmacological sciences 20040401

Title: PKA- and PKC-dependent regulation of angiopoietin 2 mRNA in human granulosa lutein cells.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040201

Title: Extracellular signal-regulated kinase 1/2 is required for the induction of group I metabotropic glutamate receptor-mediated epileptiform discharges.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040107

Title: Protein kinase C modulation of cyclic GMP in rat neonatal pulmonary vascular smooth muscle.

Journal: Lung 20040101

Title: Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation.

Journal: British journal of pharmacology 20031201

Title: Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.

Journal: The Journal of biological chemistry 20020405

Title: Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.

Journal: FEBS letters 19960826

Title: Gschwendt M, et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett, 1996, 392(2), 77-80.

Title: Peterman EE, et al. G0 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol, 2004, 43(5), 645-656.

Title: Young LH, et al. G0 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev, 2005, 23(3), 255-272.

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SDS
Tags:133053-19-7 Molecular Formula|133053-19-7 MDL|133053-19-7 SMILES|133053-19-7 Go 6983
Catalog No.: AA0011IH
133053-19-7,MFCD04040031
133053-19-7 | Go 6983
Pack Size: 1mg
Purity: ≥98%
in stock
$63.00 $44.00
Pack Size: 5mg
Purity: ≥98%
in stock
$209.00 $146.00
Pack Size: 50mg
Purity: 95%
in stock
$252.00 $177.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0011IH
Chemical Name: Go 6983
CAS Number: 133053-19-7
Molecular Formula: C26H26N4O3
Molecular Weight: 442.5096
MDL Number: MFCD04040031
SMILES: COc1ccc2c(c1)c(cn2CCCN(C)C)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2
Properties
BP: 709°C at 760 mmHg  
Form: Solid  
Solubility: DMSO: 20 mg/mL, clear, red  
Storage: Inert atmosphere;-20 ℃;  
Complexity: 796  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 33  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.1  
Downstream Synthesis Route
1064777-83-8   
CASUnavailable 
  133053-19-7 

[1]CurrentPatentAssignee:GYEONGSANGNATIONALUNIVERSITY-WO2008/117935,2008,A1Locationinpatent:Page/Pagecolumn32

879-37-8   
GO6983 

[1]Patent:WO2008/117935,2008,A1

1064777-55-4    133053-19-7 

[1]CurrentPatentAssignee:GYEONGSANGNATIONALUNIVERSITY-WO2008/117935,2008,A1

1064777-81-6    133053-19-7 

[1]CurrentPatentAssignee:GYEONGSANGNATIONALUNIVERSITY-WO2008/117935,2008,A1

Literature fold

Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure influence the expression of glutamate transporter GLT-1 in C6 glioma cells via the Ca(2+) /protein kinase C pathway.

Journal: Journal of applied toxicology : JAT20161101

Title: p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).

Journal: The Journal of biological chemistry20160318

Title: Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.

Journal: The Biochemical journal20130901

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels.

Journal: The Biochemical journal20121115

Title: Novel regulation of protein kinase C-η.

Journal: Biochemical and biophysical research communications20120907

Title: Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20120901

Title: Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.

Journal: Investigative ophthalmology & visual science20120501

Title: Interferon-γ-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway.

Journal: Immunobiology20120401

Title: Regulation and rate limiting mechanisms of Ca2+ ATPase (SERCA2) expression in cardiac myocytes.

Journal: Molecular and cellular biochemistry20120201

Title: The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.

Journal: Cellular signalling20120101

Title: Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells.

Journal: Cellular signalling20120101

Title: Reduced calcium current density in female versus male mouse adrenal chromaffin cells in situ.

Journal: Cell calcium20120101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Inhibition of protein kinase C promotes differentiation of neuroblastoma × glioma NG108-15 hybrid cells.

Journal: The European journal of neuroscience20111001

Title: Protective effect of 4,4'-diaminodiphenylsulfone against paraquat-induced mouse lung injury.

Journal: Experimental & molecular medicine20110930

Title: Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha.

Journal: Cellular signalling20110901

Title: Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.

Journal: The Journal of biological chemistry20110826

Title: Protein kinase D regulates the adiponectin gene expression through phosphorylation of AP-2: a common pathway to the ABCA1 gene regulation.

Journal: Atherosclerosis20110501

Title: Proteomic analysis of cPKCβII-interacting proteins involved in HPC-induced neuroprotection against cerebral ischemia of mice.

Journal: Journal of neurochemistry20110401

Title: PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.

Journal: BMB reports20110201

Title: Differential roles of phosphorylated AMPA receptor GluR1 subunits at Serine-831 and Serine-845 sites in spinal cord dorsal horn in a rat model of post-operative pain.

Journal: Neurochemical research20110101

Title: Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.

Journal: British journal of pharmacology20100801

Title: Rapid activation of dormant presynaptic terminals by phorbol esters.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100728

Title: SSeCKS promote beta-amyloid-induced PC12 cells neurotoxicity by up-regulating tau phosphorylation in Alzheimer's disease.

Journal: Molecular and cellular biochemistry20100701

Title: Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.

Journal: The Prostate20100701

Title: [Effect of PKC signalling pathway and aldose reductase on expression of fibronectin induced by transforming growth factor-β1 in human mesangial cells].

Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology20100601

Title: Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2.

Journal: Cellular signalling20091101

Title: Anti-cancer activity and mechanistic features of a NK cell activating molecule.

Journal: Cancer immunology, immunotherapy : CII20091001

Title: Establishment of screening system toward discovery of kinase inhibitors using label-free on-chip phosphorylation assays.

Journal: Bio Systems20090901

Title: Involvement of protein kinase C in IL-1beta-induced expression of cyclooxygenase-2 in human gingival fibroblasts.

Journal: Journal of oral science20090901

Title: Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake.

Journal: American journal of physiology. Endocrinology and metabolism20090801

Title: Cortical F-actin, the exocytic mode, and neuropeptide release in mouse chromaffin cells is regulated by myristoylated alanine-rich C-kinase substrate and myosin II.

Journal: Molecular biology of the cell20090701

Title: Low-power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway.

Journal: Journal of cellular physiology20090601

Title: Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.

Journal: The Journal of biological chemistry20090515

Title: Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation.

Journal: Investigative ophthalmology & visual science20090201

Title: Phosphatidylethanol mediates its effects on the vascular endothelial growth factor via HDL receptor in endothelial cells.

Journal: Alcoholism, clinical and experimental research20090201

Title: Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20090201

Title: Leptin stimulated C-reactive protein production by human coronary artery endothelial cells.

Journal: Journal of vascular research20090101

Title: Low-power laser irradiation activates Src tyrosine kinase through reactive oxygen species-mediated signaling pathway.

Journal: Journal of cellular physiology20081101

Title: PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.

Journal: International journal of cancer20080815

Title: Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C.

Journal: Cellular signalling20080701

Title: Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.

Journal: Bioorganic & medicinal chemistry20080415

Title: Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells.

Journal: Regulatory peptides20080410

Title: Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.

Journal: Experimental and molecular pathology20080201

Title: nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells.

Journal: American journal of physiology. Cell physiology20071101

Title: Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells.

Journal: Liver international : official journal of the International Association for the Study of the Liver20071001

Title: Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.

Journal: American journal of physiology. Lung cellular and molecular physiology20070801

Title: Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin.

Journal: Journal of immunology (Baltimore, Md. : 1950)20070501

Title: Regulation of anion exchanger Slc26a6 by protein kinase C.

Journal: American journal of physiology. Cell physiology20070401

Title: Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis.

Journal: Journal of neurochemistry20070101

Title: Beta(2)-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP.

Journal: Diabetologia20070101

Title: Lactoferrin stimulates erythrocyte Na+/K+ -adenosine triphosphatase: effect of some modulators of membrane phosphorylation.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20070101

Title: Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20060915

Title: Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway.

Journal: Biochemical and biophysical research communications20060217

Title: Effect of topiramate and dBcAMP on expression of the glutamate transporters GLAST and GLT-1 in astrocytes cultured separately, or together with neurons.

Journal: Neurochemistry international20060101

Title: Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle.

Journal: Lung20060101

Title: Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes.

Journal: The Journal of biological chemistry20050729

Title: Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor.

Journal: The Journal of biological chemistry20050513

Title: Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor.

Journal: The Journal of biological chemistry20050211

Title: Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983).

Journal: Molecular pharmacology20050201

Title: alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway.

Journal: Endocrinology20050201

Title: Metabolic arrest and its regulation in anoxic eel hepatocytes.

Journal: Physiological and biochemical zoology : PBZ20050101

Title: Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.

Journal: Cardiovascular drug reviews20050101

Title: A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20041201

Title: IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.

Journal: Microbes and infection20041101

Title: Possible involvement of protein kinase C activation in differentiation of human umbilical vein endothelium-derived cell into smooth muscle-like cell.

Journal: Biology of the cell20040901

Title: Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes.

Journal: Cardiovascular research20040815

Title: Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation.

Journal: Molecules and cells20040630

Title: PfPKB, a novel protein kinase B-like enzyme from Plasmodium falciparum: I. Identification, characterization, and possible role in parasite development.

Journal: The Journal of biological chemistry20040604

Title: PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice.

Journal: European journal of pharmacology20040525

Title: Mechanism of human urotensin II-induced contraction in rat aorta.

Journal: Journal of pharmacological sciences20040401

Title: PKA- and PKC-dependent regulation of angiopoietin 2 mRNA in human granulosa lutein cells.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20040201

Title: Extracellular signal-regulated kinase 1/2 is required for the induction of group I metabotropic glutamate receptor-mediated epileptiform discharges.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20040107

Title: Protein kinase C modulation of cyclic GMP in rat neonatal pulmonary vascular smooth muscle.

Journal: Lung20040101

Title: Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation.

Journal: British journal of pharmacology20031201

Title: Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.

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Title: Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.

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Title: Gschwendt M, et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett, 1996, 392(2), 77-80.

Title: Peterman EE, et al. G0 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol, 2004, 43(5), 645-656.

Title: Young LH, et al. G0 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev, 2005, 23(3), 255-272.

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