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1456858-58-4,MFCD28167714
Catalog No.:AA00ABHK

1456858-58-4 | Hg-9-91-01

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$173.00   $121.00
- +
2mg
in stock  
$322.00   $225.00
- +
5mg
in stock  
$406.00   $284.00
- +
10mg
in stock  
$620.00   $434.00
- +
50mg
95%
in stock  
$912.00   $639.00
- +
100mg
95%
in stock  
$1,547.00   $1,083.00
- +
250mg
95%
in stock  
$3,222.00   $2,255.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ABHK
Chemical Name:
Hg-9-91-01
CAS Number:
1456858-58-4
Molecular Formula:
C32H37N7O3
Molecular Weight:
567.6813
MDL Number:
MFCD28167714
SMILES:
COc1cc(OC)ccc1N(C(=O)Nc1c(C)cccc1C)c1ncnc(c1)Nc1ccc(cc1)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
825  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.3  

Literature

Title: SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.

Journal: Journal of leukocyte biology 20160501

Title: Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20121016

Title: Clark K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated andregulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.

Title: Sundberg TB, et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73.

Title: Patel K, et al.The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat Commun. 2014 Aug 4;5:4535.

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SDS
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Tags:1456858-58-4 Molecular Formula|1456858-58-4 MDL|1456858-58-4 SMILES|1456858-58-4 Hg-9-91-01
Catalog No.: AA00ABHK
1456858-58-4,MFCD28167714
1456858-58-4 | Hg-9-91-01
Pack Size： 1mg
Purity： ≥95%
in stock
$173.00 $121.00
Pack Size： 2mg
Purity：
in stock
$322.00 $225.00
Pack Size： 5mg
Purity：
in stock
$406.00 $284.00
Pack Size： 10mg
Purity：
in stock
$620.00 $434.00
Pack Size： 50mg
Purity： 95%
in stock
$912.00 $639.00
Pack Size： 100mg
Purity： 95%
in stock
$1,547.00 $1,083.00
Pack Size： 250mg
Purity： 95%
in stock
$3,222.00 $2,255.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00ABHK
Chemical Name: Hg-9-91-01
CAS Number: 1456858-58-4
Molecular Formula: C32H37N7O3
Molecular Weight: 567.6813
MDL Number: MFCD28167714
SMILES: COc1cc(OC)ccc1N(C(=O)Nc1c(C)cccc1C)c1ncnc(c1)Nc1ccc(cc1)N1CCN(CC1)C
Properties
Complexity: 825  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 42  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.3  
Literature fold

Title: SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.

Journal: Journal of leukocyte biology20160501

Title: Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.

Journal: Proceedings of the National Academy of Sciences of the United States of America20121016

Title: Clark K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated andregulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.

Title: Sundberg TB, et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73.

Title: Patel K, et al.The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat Commun. 2014 Aug 4;5:4535.

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