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175519-16-1,MFCD00946608
Catalog No.:AA00ABJ9

175519-16-1 | Voreloxin Hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$268.00   $188.00
- +
10mg
95%
in stock  
$427.00   $299.00
- +
25mg
95%
in stock  
$890.00   $623.00
- +
50mg
95%
in stock  
$1,382.00   $968.00
- +
100mg
95%
in stock  
$2,443.00   $1,710.00
- +
200mg
95%
in stock  
$4,352.00   $3,047.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABJ9
Chemical Name:
Voreloxin Hydrochloride
CAS Number:
175519-16-1
Molecular Formula:
C18H20ClN5O4S
Molecular Weight:
437.9005
MDL Number:
MFCD00946608
SMILES:
CNC1CN(CC1OC)c1ccc2c(n1)n(cc(c2=O)C(=O)O)c1nccs1.Cl
Properties
Computed Properties
 
Complexity:
662  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  

Literature

Title: Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2.

Journal: Journal of medicinal chemistry 20040408

Title: Hotinski AK, et al. Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia. Expert Opin Pharmacother. 2015 Jun;16(9):1395-402.

Title: Scatena CD, et al. Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8.

Title: Walsby EJ, et al. The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine. Haematologica. 2011 Mar;96(3):393-9.

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Tags:175519-16-1 Molecular Formula|175519-16-1 MDL|175519-16-1 SMILES|175519-16-1 Voreloxin Hydrochloride