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29976-75-8,MFCD00017461
Catalog No.:AA00BD0F

29976-75-8 | 6-Methylflavone

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250mg
98%
in stock  
$99.00   $69.00
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1g
≥ 98% (HPLC)
in stock  
$127.00   $89.00
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5g
≥ 98% (HPLC)
in stock  
$454.00   $318.00
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25g
≥ 98% (HPLC)
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$1,857.00   $1,300.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BD0F
Chemical Name:
6-Methylflavone
CAS Number:
29976-75-8
Molecular Formula:
C16H12O2
Molecular Weight:
236.2653
MDL Number:
MFCD00017461
SMILES:
Cc1ccc2c(c1)c(=O)cc(o2)c1ccccc1
Properties
Properties
 
Form:
Solid  
MP:
119-122℃ (dec.)(lit.)  

Computed Properties
 
Complexity:
352  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.9  

Downstream Synthesis Route

[1]JournalofChemicalResearch,2009,p.27-29

[2]ComptesRendusChimie,2016,vol.19,p.551-555

[3]OrganicPreparationsandProceduresInternational,2009,vol.41,p.69-75

[4]SyntheticCommunications,2009,vol.39,p.4199-4211

[5]JournaloftheIndianChemicalSociety,2006,vol.83,p.835-837

[6]BulletinoftheChemicalSocietyofJapan,1987,vol.60,p.1919-1920

[7]JournalofChemicalResearch,2005,p.556-557

[8]AppliedCatalysisA:General,2011,vol.404,p.68-73

[9]MedicinalChemistryResearch,2012,vol.21,p.1833-1849,17

[10]Molecules,2018,vol.23

[11]EuropeanJournalofMedicinalChemistry,2014,vol.73,p.195-209

[12]AdvancedSynthesisandCatalysis,2019,vol.361,p.3318-3323

[13]TetrahedronLetters,2016,vol.57,p.3841-3843

[14]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1987,vol.26,p.873-876

[15]Heterocycles,1986,vol.24,p.2511-2517

[16]JournalofOrganicChemistry,1991,vol.56,p.7292-7297

[17]JournalofMedicinalChemistry,2002,vol.45,p.4188-4201

[18]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2012,vol.51,p.770-773

[1]Kahnberg,Pia;Lager,Erik;Rosenberg,Celia;Schougaard,Jette;Camet,Linda;Sterner,Olov;Nielsen,ElsebetØstergaard;Nielsen,Mogens;Liljefors,Tommy[JournalofMedicinalChemistry,2002,vol.45,#19,p.4188-4201]

[1]AngewandteChemie-InternationalEdition,2011,vol.50,p.3769-3773

[1]Locationinpatent:experimentalpartKim,Donghee;Ham,Kyungrok;Hong,Sungwoo[OrganicandBiomolecularChemistry,2012,vol.10,#36,p.7305-7312]

[1]AngewandteChemie-InternationalEdition,2012,vol.51,p.11333-11336,4

Literature

Title: In vitro cytotoxic activity of novel protoflavone analogs - selectivity towards a multidrug resistant cancer cell line.

Journal: Anticancer research 20120701

Title: Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands.

Journal: Journal of medicinal chemistry 20090924

Title: Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: QSAR modeling of the interaction of flavonoids with GABA(A) receptor.

Journal: European journal of medicinal chemistry 20080801

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes.

Journal: European journal of pharmacology 20050411

Title: Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors.

Journal: European journal of pharmacology 20040426

Title: Insect antifeedant activity of flavones and chromones against Spodoptera litura.

Journal: Journal of agricultural and food chemistry 20030115

Title: Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor.

Journal: Journal of medicinal chemistry 20020912

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

Title: Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex.

Journal: Journal of medicinal chemistry 19991021

Title: Hall BJ, et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol. 2004 Apr 26;491(1):1-8.

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