Title: Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype.
Journal: Chemico-biological interactions 20180301
Title: Production of bioactive ginsenoside compound K in metabolically engineered yeast.
Journal: Cell research 20140601
Title: Absorption mechanism of ginsenoside compound K and its butyl and octyl ester prodrugs in Caco-2 cells.
Journal: Journal of agricultural and food chemistry 20121017
Title: Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120801
Title: Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer.
Journal: International journal of oncology 20120601
Title: Compound K, a novel ginsenoside metabolite, inhibits adipocyte differentiation in 3T3-L1 cells: involvement of angiogenesis and MMPs.
Journal: Biochemical and biophysical research communications 20120601
Title: Enzymatic biotransformation of ginsenoside Rb1 to compound K by recombinant β-glucosidase from Microbacterium esteraromaticum.
Journal: Journal of agricultural and food chemistry 20120411
Title: Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20120401
Title: Co-transformation of Panax major ginsenosides Rb₁ and Rg₁ to minor ginsenosides C-K and F₁ by Cladosporium cladosporioides.
Journal: Journal of industrial microbiology & biotechnology 20120401
Title: Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway.
Journal: Journal of cellular and molecular medicine 20120101
Title: Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis.
Journal: Fitoterapia 20120101
Title: Snailase preparation of ginsenoside M1 from protopanaxadiol-type ginsenoside and their protective effects against CCl4-induced chronic hepatotoxicity in mice.
Journal: Molecules (Basel, Switzerland) 20111206
Title: Ginsenoside metabolite compound K differentially antagonizing tumor necrosis factor-α-induced monocyte-endothelial trafficking.
Journal: Chemico-biological interactions 20111015
Title: Subchronic toxicity studies with ginsenoside compound K delivered to dogs via intravenous administration.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801
Title: Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation.
Journal: Biochemical pharmacology 20110801
Title: Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110601
Title: Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway.
Journal: Life sciences 20110411
Title: Ginsenoside compound K attenuates metastatic growth of hepatocellular carcinoma, which is associated with the translocation of nuclear factor-κB p65 and reduction of matrix metalloproteinase-2/9.
Journal: Planta medica 20110301
Title: Compound K increases type I procollagen level and decreases matrix metalloproteinase-1 activity and level in ultraviolet-A-irradiated fibroblasts.
Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20110301
Title: Production of aglycon protopanaxadiol via compound K by a thermostable β-glycosidase from Pyrococcus furiosus.
Journal: Applied microbiology and biotechnology 20110201
Title: Post-exposure treatment with ginsenoside compound K ameliorates auditory functional injury associated with noise-induced hearing loss in mice.
Journal: Neuroscience letters 20110107
Title: Compound K, a metabolite of ginsenosides, facilitates spontaneous GABA release onto CA3 pyramidal neurons.
Journal: Journal of neurochemistry 20100801
Title: Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes.
Journal: Journal of agricultural and food chemistry 20100526
Title: Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice.
Journal: Transplant immunology 20100501
Title: Compound K inhibits basic fibroblast growth factor-induced angiogenesis via regulation of p38 mitogen activated protein kinase and AKT in human umbilical vein endothelial cells.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells.
Journal: International journal of molecular sciences 20100101
Title: Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells.
Journal: Journal of agricultural and food chemistry 20091125
Title: Glucocorticoid receptor agonist compound K regulates Dectin-1-dependent inflammatory signaling through inhibition of reactive oxygen species.
Journal: Life sciences 20091021
Title: Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo.
Journal: Journal of agricultural and food chemistry 20090708
Title: Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells.
Journal: Journal of agricultural and food chemistry 20090225
Title: Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells.
Journal: BMC cancer 20090101
Title: Compound K suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair in human keratinocytes.
Journal: Archives of pharmacal research 20081101
Title: The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock.
Journal: Journal of cellular and molecular medicine 20080901
Title: Development and validation of a reversed-phase HPLC method for quantitative determination of ginsenosides Rb1, Rd, F2, and compound K during the process of biotransformation of ginsenoside Rb1.
Journal: Journal of separation science 20080401
Title: Biotransformation of Panax notoginseng saponins into ginsenoside compound K production by Paecilomyces bainier sp. 229.
Journal: Journal of applied microbiology 20080301
Title: A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells.
Journal: Oncology reports 20080301
Title: Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice.
Journal: Journal of agricultural and food chemistry 20071226
Title: Transformation of bioactive compounds by Fusarium sacchari fungus isolated from the soil-cultivated ginseng.
Journal: Journal of agricultural and food chemistry 20071114
Title: Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice.
Journal: Biological & pharmaceutical bulletin 20071101
Title: Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method.
Journal: Chemical & pharmaceutical bulletin 20071001
Title: [Advances in the study of ginsenoside compound K].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070901
Title: Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells.
Journal: Neuroscience letters 20070621
Title: Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes.
Journal: Cardiovascular research 20070401
Title: Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression.
Journal: Journal of agricultural and food chemistry 20070307
Title: Purification and characterization of new special ginsenosidase hydrolyzing multi-glycisides of protopanaxadiol ginsenosides, ginsenosidase type I.
Journal: Chemical & pharmaceutical bulletin 20070201
Title: A ginsenoside metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, triggers apoptosis in activated rat hepatic stellate cells via caspase-3 activation.
Journal: Planta medica 20061001
Title: Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells.
Journal: International journal of cancer 20060115
Title: Pharmacokinetics of a ginseng saponin metabolite compound K in rats.
Journal: Biopharmaceutics & drug disposition 20060101
Title: Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20051001
Title: Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models.
Journal: Journal of pharmacological sciences 20050901
Title: Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis.
Journal: International immunopharmacology 20050701
Title: [Determination of ginsenoside compound-K by reversed-phase high performance liquid chromatography].
Journal: Se pu = Chinese journal of chromatography 20050501
Title: Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide.
Journal: Biological & pharmaceutical bulletin 20050401
Title: Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora.
Journal: Biological & pharmaceutical bulletin 20041001
Title: Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin.
Journal: Biochemical and biophysical research communications 20040402
Title: Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
Journal: Molecules and cells 20040227
Title: A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells.
Journal: International journal of oncology 20031001
Title: Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes.
Journal: Archives of pharmacal research 20031001
Title: Degradation of ginsenosides in humans after oral administration.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030801
Title: Inhibition of intracerebroventricular injection stress-induced plasma corticosterone levels by intracerebroventricularly administered compound K, a ginseng saponin metabolite, in mice.
Journal: Biological & pharmaceutical bulletin 20030701
Title: Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20020101
Title: The antimetastatic and immunomodulating activities of ginseng minor glycosides.
Journal: Doklady. Biochemistry and biophysics 20010101
Title: Kim JH, et al. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responsesand diseases. J Ginseng Res. 2017 Oct;41(4):435-443.
Title: Liu Y, et al. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci. 2006 Jun;91(2):356-64.
Title: Zhang J, et al. Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis. Drug Metab Dispos. 2015 Aug;43(8):1181-9.
Title: Liu KK, et al. Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis. Acta Pharmacol Sin. 2014 May;35(5):599-612.
