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206645-99-0,MFCD09263618
Catalog No.:AA00C1CP

206645-99-0 | Compstatin

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Purity
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Price(USD)
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1mg
99%
in stock  
$18.00   $13.00
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5mg
99%
in stock  
$38.00   $27.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C1CP
Chemical Name:
Compstatin
CAS Number:
206645-99-0
Molecular Formula:
C66H99N23O17S2
Molecular Weight:
1550.7662
MDL Number:
MFCD09263618
SMILES:
CC[C@@H]([C@@H](C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2nc[nH]c2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)CCC(=O)N)CC(=O)O)Cc1c[nH]c2c1cccc2)Cc1nc[nH]c1)C(=O)N[C@H](C(=O)N)[C@H](O)C)N)C
Properties
Computed Properties
 
Complexity:
3180  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
14  
Heavy Atom Count:
108  
Hydrogen Bond Acceptor Count:
23  
Hydrogen Bond Donor Count:
22  
Rotatable Bond Count:
25  
XLogP3:
-6.7  

Literature

Title: Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention.

Journal: Molecular oral microbiology 20160201

Title: Complement, a target for therapy in inflammatory and degenerative diseases.

Journal: Nature reviews. Drug discovery 20151201

Title: Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy.

Journal: Immunobiology 20150801

Title: Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention.

Journal: European journal of clinical investigation 20150401

Title: A new generation of potent complement inhibitors of the Compstatin family.

Journal: Chemical biology & drug design 20110601

Title: Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration.

Journal: Advances in experimental medicine and biology 20100101

Title: Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20091115

Title: Structure-activity relationships for substrate-based inhibitors of human complement factor B.

Journal: Journal of medicinal chemistry 20091008

Title: Complement activation by bisretinoid constituents of RPE lipofuscin.

Journal: Investigative ophthalmology & visual science 20090301

Title: Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin.

Journal: Journal of molecular recognition : JMR 20090101

Title: Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation.

Journal: Transplantation 20080427

Title: Small-molecule complement inhibitors cannot prevent the development of the platelet storage lesion.

Journal: Transfusion 20080401

Title: Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.

Journal: Bioorganic & medicinal chemistry 20080215

Title: Compstatin: a complement inhibitor on its way to clinical application.

Journal: Advances in experimental medicine and biology 20080101

Title: Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.

Journal: Journal of medicinal chemistry 20060727

Title: Expression of compstatin in Escherichia coli: incorporation of unnatural amino acids enhances its activity.

Journal: Protein expression and purification 20060501

Title: Design and NMR characterization of active analogues of compstatin containing non-natural amino acids.

Journal: Journal of medicinal chemistry 20050113

Title: Thermodynamic studies on the interaction of the third complement component and its inhibitor, compstatin.

Journal: The Journal of biological chemistry 20041231

Title: Synthetic small-molecule complement inhibitors.

Journal: Current opinion in investigational drugs (London, England : 2000) 20041101

Title: Studies of structure-activity relations of complement inhibitor compstatin.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030815

Title: Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20000901

Title: Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19960715

Title: Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21.

Title: Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65.

Title: Bert J C Janssen, et al. Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem. 2007 Oct 5;282(40):29241-7.

Title: A Sahu, et al. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol. 1996 Jul 15;157(2):884-91.

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