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30271-38-6,MFCD31544368
Catalog No.:AA00C2PJ

30271-38-6 | 24-Hydroxycholesterol

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2mg
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1 week  
$265.00   $185.00
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5mg
98%
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  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C2PJ
Chemical Name:
24-Hydroxycholesterol
CAS Number:
30271-38-6
Molecular Formula:
C27H46O2
Molecular Weight:
402.6529
MDL Number:
MFCD31544368
SMILES:
O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC(C(C)C)O)C)C)C1)C
Properties
Computed Properties
 
Complexity:
624  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
7  

Literature

Title: Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols.

Journal: PloS one 20140101

Title: Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat.

Journal: Acta ophthalmologica 20121101

Title: Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration.

Journal: Investigative ophthalmology & visual science 20121009

Title: Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease.

Journal: Journal of neurochemistry 20121001

Title: Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells.

Journal: Neuroscience letters 20120906

Title: Cholesterol loss during glutamate-mediated excitotoxicity.

Journal: The EMBO journal 20120404

Title: Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease.

Journal: Cell death and differentiation 20120301

Title: Interactions of amyloid β peptide 1-40 and cerebrosterol.

Journal: Neurochemical research 20120301

Title: Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.

Journal: Neurochemistry international 20120101

Title: Nuclear receptors in nonalcoholic Fatty liver disease.

Journal: Journal of lipids 20120101

Title: side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons.

Journal: Neuro-degenerative diseases 20120101

Title: Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease.

Journal: Journal of Alzheimer's disease : JAD 20120101

Title: Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients.

Journal: Lipids in health and disease 20120101

Title: Beta-amyloid peptides enhance the proliferative response of activated CD4CD28 lymphocytes from Alzheimer disease patients and from healthy elderly.

Journal: PloS one 20120101

Title: Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation.

Journal: Journal of Alzheimer's disease : JAD 20120101

Title: Spatial distribution of the pathways of cholesterol homeostasis in human retina.

Journal: PloS one 20120101

Title: ABC Transporters and the Alzheimer's Disease Enigma.

Journal: Frontiers in psychiatry 20120101

Title: Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.

Journal: Journal of internal medicine 20111001

Title: 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.

Journal: Chemistry and physics of lipids 20110901

Title: Oxidative damage in ischemic stroke revealed using multiple biomarkers.

Journal: Stroke 20110801

Title: Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism.

Journal: The Journal of biological chemistry 20110722

Title: 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis.

Journal: The Journal of biological chemistry 20110715

Title: Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?

Journal: Free radical biology & medicine 20110615

Title: Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime.

Journal: Aging cell 20110601

Title: Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20110601

Title: Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?

Journal: Experimental gerontology 20110401

Title: Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain.

Journal: Journal of proteome research 20110107

Title: Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain.

Journal: Investigative ophthalmology & visual science 20110101

Title: Complex genetic mechanisms in glaucoma: an overview.

Journal: Indian journal of ophthalmology 20110101

Title: Role of cholesterol 24S-hydroxylase gene polymorphism (rs754203) in primary open angle glaucoma.

Journal: Molecular vision 20110101

Title: Lipid pathway alterations in Parkinson's disease primary visual cortex.

Journal: PloS one 20110101

Title: Mechanisms of oxysterol-induced carcinogenesis.

Journal: Lipids in health and disease 20110101

Title: Oxysterol derivatives of cholesterol in neurodegenerative disorders.

Journal: Current medicinal chemistry 20110101

Title: Function and comorbidities of apolipoprotein e in Alzheimer's disease.

Journal: International journal of Alzheimer's disease 20110101

Title: Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments.

Journal: Journal of ophthalmology 20110101

Title: Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease.

Journal: Frontiers in neurology 20110101

Title: Processing of endogenous AβPP in blood-brain barrier endothelial cells is modulated by liver-X receptor agonists and altered cellular cholesterol homeostasis.

Journal: Journal of Alzheimer's disease : JAD 20110101

Title: Lipids, lipoproteins, and age-related macular degeneration.

Journal: Journal of lipids 20110101

Title: ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage.

Journal: PloS one 20110101

Title: Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina.

Journal: BMC ophthalmology 20110101

Title: Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.

Journal: Lipids in health and disease 20110101

Title: Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study.

Journal: BMC neurology 20110101

Title: Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus.

Journal: PloS one 20110101

Title: Inflammatory-induced hibernation in the fetus: priming of fetal sheep metabolism correlates with developmental brain injury.

Journal: PloS one 20110101

Title: The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease.

Journal: ISRN neurology 20110101

Title: Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits.

Journal: Molecular and cellular neurosciences 20101201

Title: LXR-α genomics programmes neuronal death observed in Alzheimer's disease.

Journal: Apoptosis : an international journal on programmed cell death 20101201

Title: Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines.

Journal: Anticancer research 20100901

Title: The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.

Journal: Neuroscience 20100811

Title: A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol).

Journal: Biochimica et biophysica acta 20100801

Title: Changes in brain cholesterol metabolome after excitotoxicity.

Journal: Molecular neurobiology 20100601

Title: Distribution of cholesterol 24-hydroxylase in the monkey brain.

Journal: Neuroscience bulletin 20100601

Title: Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.

Journal: IUBMB life 20100401

Title: 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury.

Journal: Brain research 20100310

Title: Vascular pathology in the aged human brain.

Journal: Acta neuropathologica 20100301

Title: The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo.

Journal: Journal of lipid research 20100201

Title: Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20100101

Title: Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.

Journal: Biochimica et biophysica acta 20100101

Title: Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs.

Journal: PloS one 20100101

Title: Cardiovascular dementia - a different perspective.

Journal: The open biochemistry journal 20100101

Title: Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.

Journal: Alzheimer disease and associated disorders 20100101

Title: Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices.

Journal: Pharmacology 20100101

Title: The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.

Journal: BMC ophthalmology 20100101

Title: Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4.

Journal: Alzheimer's research & therapy 20100101

Title: Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.

Journal: Investigative ophthalmology & visual science 20091201

Title: Polar metabolite of cholesterol induces rat cognitive dysfunctions.

Journal: Neuroscience 20091201

Title: Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.

Journal: Neuroscience letters 20091002

Title: 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20091001

Title: Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals.

Journal: Neurobiology of aging 20090601

Title: Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.

Journal: Biochemistry 20090519

Title: Central nervous system: cholesterol turnover, brain development and neurodegeneration.

Journal: Biological chemistry 20090401

Title: CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20090401

Title: Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase.

Journal: Archives of biochemistry and biophysics 20090301

Title: Sterols in the central nervous system.

Journal: Current opinion in clinical nutrition and metabolic care 20090301

Title: Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.

Journal: Journal of lipid research 20090201

Title: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells.

Journal: Molecular neurodegeneration 20090101

Title: Oxysterols as markers of neurological disease--a review.

Journal: Scandinavian journal of clinical and laboratory investigation 20090101

Title: Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease.

Journal: Dementia and geriatric cognitive disorders 20090101

Title: Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death.

Journal: PloS one 20090101

Title: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.

Journal: Journal of neurochemistry 20081201

Title: A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels.

Journal: Bioscience, biotechnology, and biochemistry 20081201

Title: Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease.

Journal: Brain : a journal of neurology 20081101

Title: Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol.

Journal: Analytical biochemistry 20081001

Title: Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.

Journal: Journal of neurotrauma 20080901

Title: Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.

Journal: Journal of neurochemistry 20080701

Title: Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury.

Journal: Brain injury 20080701

Title: Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample.

Journal: Free radical biology & medicine 20080401

Title: The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome.

Journal: Journal of proteome research 20080401

Title: Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers.

Journal: Neurochemical research 20080301

Title: [Synthesis of sterols oxygenated in the terminal fragment of their side chains].

Journal: Bioorganicheskaia khimiia 20080101

Title: Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis.

Journal: PPAR research 20080101

Title: Liver x receptor: a novel therapeutic target.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20071226

Title: Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis.

Journal: Journal of neurochemistry 20071201

Title: Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier.

Journal: Journal of neurochemistry 20071101

Title: Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1.

Journal: International journal of clinical pharmacology and therapeutics 20071101

Title: Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders.

Journal: Neuroscience letters 20070925

Title: Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.

Journal: Human molecular genetics 20070915

Title: Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers.

Journal: Atherosclerosis 20070901

Title: Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: effects of gender, CYP46, and ApoE polymorphisms.

Journal: Journal of molecular neuroscience : MN 20070901

Title: Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway.

Journal: Biochemical and biophysical research communications 20070720

Title: Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi).

Journal: Lipids 20070701

Title: 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis.

Journal: Journal of neuroscience research 20070515

Title: Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.

Journal: Journal of internal medicine 20070501

Title: Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols.

Journal: Journal of lipid research 20070401

Title: Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells.

Journal: Current eye research 20070301

Title: Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation.

Journal: The Journal of biological chemistry 20070202

Title: 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression.

Journal: Journal of neurochemistry 20070201

Title: Rediscovery of cerebrosterol.

Journal: Lipids 20070201

Title: Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

Journal: Cell metabolism 20070101

Title: [A new synthesis of cerebrosterol and its 24-epimer from lithocholic acid].

Journal: Bioorganicheskaia khimiia 20070101

Title: Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry.

Journal: Methods in enzymology 20070101

Title: Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

Journal: Journal of internal medicine 20061201

Title: Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis.

Journal: Clinical neurology and neurosurgery 20060701

Title: High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels.

Journal: Journal of clinical pharmacology 20060701

Title: Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury.

Journal: Journal of neuropathology and experimental neurology 20060701

Title: 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

Journal: The Journal of biological chemistry 20060505

Title: Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease.

Journal: International journal of molecular medicine 20060501

Title: Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer's disease.

Journal: Expert review of neurotherapeutics 20060501

Title: Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?

Journal: Neuroscience letters 20060401

Title: Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin.

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population.

Journal: International psychogeriatrics 20060301

Title: Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060201

Title: Circulating biomarkers of cognitive decline and dementia.

Journal: Clinica chimica acta; international journal of clinical chemistry 20060201

Title: Effect of pravastatin on plasma sterols and oxysterols in men.

Journal: European journal of clinical pharmacology 20060101

Title: Cholesterol metabolism in the brain: importance of 24S-hydroxylation.

Journal: Acta neurologica Scandinavica. Supplementum 20060101

Title: Oxysterols and Alzheimer's disease.

Journal: Acta neurologica Scandinavica. Supplementum 20060101

Title: Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease.

Journal: Journal of biomedicine & biotechnology 20060101

Title: Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20051001

Title: A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.

Journal: The Journal of clinical psychiatry 20050701

Title: 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells.

Journal: Neuroreport 20050621

Title: Effect of raloxifene and hormone therapy on serum markers of brain and whole-body cholesterol metabolism in postmenopausal women.

Journal: Maturitas 20050411

Title: Cholesterol homeostasis in neurons and glial cells.

Journal: Seminars in cell & developmental biology 20050401

Title: Biological markers in CSF and blood for axonal degeneration in multiple sclerosis.

Journal: The Lancet. Neurology 20050101

Title: Cholesterol and apolipoprotein E in Alzheimer's disease.

Journal: American journal of Alzheimer's disease and other dementias 20050101

Title: Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.

Journal: PLoS biology 20041001

Title: Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients.

Journal: Neuroscience letters 20040930

Title: Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke?

Journal: Neuroscience letters 20040923

Title: Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease.

Journal: Neurobiology of aging 20040901

Title: Differential expression of cholesterol hydroxylases in Alzheimer's disease.

Journal: The Journal of biological chemistry 20040813

Title: Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal.

Journal: Journal of lipid research 20040801

Title: High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs.

Journal: Steroids 20040601

Title: Brain cholesterol: long secret life behind a barrier.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040501

Title: Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry.

Journal: Journal of lipid research 20040401

Title: Diagnostic use of cerebral and extracerebral oxysterols.

Journal: Clinical chemistry and laboratory medicine 20040201

Title: The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins.

Journal: Current Alzheimer research 20040201

Title: Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.

Journal: Journal of lipid research 20040101

Title: Linking lipids, Alzheimer's and LXRs?

Journal: Nuclear receptor signaling 20040101

Title: Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.

Journal: Biochemistry 20031209

Title: Combination of serum markers related to several mechanisms in Alzheimer's disease.

Journal: Neurobiology of aging 20031101

Title: 24S-hydroxycholesterol: a marker of brain cholesterol metabolism.

Journal: Pharmacopsychiatry 20030901

Title: Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients.

Journal: Neuroscience letters 20030828

Title: On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.

Journal: Journal of lipid research 20030801

Title: Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.

Journal: The Journal of biological chemistry 20030620

Title: Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers.

Journal: Journal of lipid research 20030401

Title: Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease.

Journal: Archives of neurology 20030401

Title: Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye.

Journal: Laboratory investigation; a journal of technical methods and pathology 20030301

Title: Serum cholesterol, precursors and metabolites and cognitive performance in an aging population.

Journal: Neurobiology of aging 20030101

Title: Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.

Journal: Archives of neurology 20030101

Title: The role of 24S-hydroxycholesterol in Alzheimer's disease.

Journal: The journal of nutrition, health & aging 20030101

Title: Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.

Journal: The Journal of biological chemistry 20021213

Title: Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis.

Journal: Neuroscience letters 20021018

Title: Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis.

Journal: The Journal of biological chemistry 20020913

Title: Metabolism of 4 beta -hydroxycholesterol in humans.

Journal: The Journal of biological chemistry 20020830

Title: Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls.

Journal: Neuroscience letters 20020510

Title: Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain.

Journal: Archives of neurology 20020201

Title: 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia.

Journal: Journal of psychiatric research 20020101

Title: Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease.

Journal: Molecular psychiatry 20020101

Title: On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells.

Journal: Neuroscience letters 20011113

Title: Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

Journal: The Journal of biological chemistry 20011019

Title: From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans.

Journal: The Journal of biological chemistry 20011005

Title: Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20010601

Title: Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol.

Journal: Journal of lipid research 20010301

Title: Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study.

Journal: Journal of lipid research 20010101

Title: Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).

Journal: Journal of lipid research 20001001

Title: Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.

Journal: The Journal of biological chemistry 20000602

Title: Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.

Journal: The Journal of biological chemistry 19970207

Title: 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver.

Journal: Biochimica et biophysica acta 19930224

Title: Soncini M, et al. 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6219-E6227. Epub 2016 Sep 26.

Title: Mast N, et al. Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. Neuropharmacology. 2017 Sep 1;123:465-476.

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Tags:30271-38-6 Molecular Formula|30271-38-6 MDL|30271-38-6 SMILES|30271-38-6 24-Hydroxycholesterol