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17320-10-4,MFCD00201408
Catalog No.:AA001YMB

17320-10-4 | 4-Beta-Hydroxycholesterol

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1mg
≥95%
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$53.00   $37.00
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5mg
≥95%
in stock  
$110.00   $77.00
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10mg
≥95%
in stock  
$203.00   $142.00
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25mg
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$405.00   $283.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001YMB
Chemical Name:
4-Beta-Hydroxycholesterol
CAS Number:
17320-10-4
Molecular Formula:
C27H46O2
Molecular Weight:
402.6529
MDL Number:
MFCD00201408
SMILES:
CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H]([C@@H]2O)O)C)C
Properties
Properties
 
Form:
Solid  
MP:
172 - 174C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
624  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
7.4  

Literature

Title: Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis.

Journal: Chemical research in toxicology 20110919

Title: Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110901

Title: A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20110715

Title: Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol.

Journal: European journal of clinical pharmacology 20110701

Title: Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians.

Journal: The pharmacogenomics journal 20110401

Title: 4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.

Journal: British journal of clinical pharmacology 20110201

Title: Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric?

Journal: Journal of clinical pharmacology 20101101

Title: 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.

Journal: International journal of clinical pharmacology and therapeutics 20091201

Title: Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.

Journal: Basic & clinical pharmacology & toxicology 20091101

Title: Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?

Journal: Clinical pharmacology and therapeutics 20090801

Title: Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols.

Journal: Journal of medicinal chemistry 20090709

Title: Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.

Journal: Journal of lipid research 20090201

Title: 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.

Journal: British journal of clinical pharmacology 20090101

Title: Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol.

Journal: Clinical pharmacology and therapeutics 20081101

Title: CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels.

Journal: European journal of clinical pharmacology 20080801

Title: Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.

Journal: British journal of clinical pharmacology 20080501

Title: 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Journal: Pharmacogenetics and genomics 20080301

Title: Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.

Journal: Pharmacogenetics and genomics 20060801

Title: Electron ionization mass spectral fragmentation of cholestane-3beta,4alpha,5alpha-triol and cholestane-3beta,5alpha,6alpha/beta-triol bis- and tris-trimethylsilyl derivatives.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Analysis of cholesterol oxidation products in biological samples.

Journal: Journal of AOAC International 20040101

Title: Metabolism of 4 beta -hydroxycholesterol in humans.

Journal: The Journal of biological chemistry 20020830

Title: Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

Journal: The Journal of biological chemistry 20011019

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Tags:17320-10-4 Molecular Formula|17320-10-4 MDL|17320-10-4 SMILES|17320-10-4 4-Beta-Hydroxycholesterol