Name: Name:9-Isopropyl-N2,N6-bis(4-methoxybenzyl)-9H-purine-2,6-diamine
Brand: AABLOCKS
SKU: AA00C2TJ
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00C2TJ

Chemical Name: 9-Isopropyl-N2,N6-bis(4-methoxybenzyl)-9H-purine-2,6-diamine

CAS Number: 267402-71-1

Molecular Formula: C24H28N6O2

Molecular Weight: 432.5181

MDL Number: MFCD02683596

SMILES: COc1ccc(cc1)CNc1nc(NCc2ccc(cc2)OC)c2c(n1)n(cn2)C(C)C

Properties

Form: Solid

Storage: Inert atmosphere;-20 ℃;

Complexity: 551

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 32

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 9

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.3

Literature fold

Title: Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.

Journal: Bioorganic & medicinal chemistry20090501

Title: Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition.

Journal: Cell motility and the cytoskeleton20080101

Title: Evaluation of novel microtubules interfering agents myoseverin, tubulyzine and E2GG in primary cultures of rat hepatocytes.

Journal: General physiology and biophysics20070901

Title: Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin.

Journal: European journal of medicinal chemistry20061201

Title: Myoseverin is a potential angiogenesis inhibitor by inhibiting endothelial cell function and endothelial progenitor cell differentiation.

Journal: DNA and cell biology20060901

Title: Small molecules driving myotube fission.

Journal: Chemistry & biology20051001

Title: A single-cell analysis of myogenic dedifferentiation induced by small molecules.

Journal: Chemistry & biology20051001

Title: A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.

Journal: Journal of the American Chemical Society20021002

Title: Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors.

Journal: Chemistry & biology20020401

Title: Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors.

Journal: Journal of medicinal chemistry20011220

Title: Rosania GR, et al. Myoseverin, a microtubule-binding molecule with novel cellular effects. Nat Biotechnol. 2000;18(3):304-308.

267402-71-1 | 9-Isopropyl-N2,N6-bis(4-methoxybenzyl)-9H-purine-2,6-diamine