Home Amines 101622-51-9
101622-51-9,MFCD00189360
Catalog No.:AA0004WG
101622-51-9 | Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
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5mg
1 week  
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25mg
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Technical Information
Catalog Number:
AA0004WG
Chemical Name:
Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
CAS Number:
101622-51-9
Molecular Formula:
C15H18N6O
Molecular Weight:
298.3430
MDL Number:
MFCD00189360
IUPAC Name:
2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol
InChI:
InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
InChI Key:
GTVPOLSIJWJJNY-UHFFFAOYSA-N
SMILES:
OCCNc1nc(NCc2ccccc2)c2c(n1)n(C)cn2
UNII:
6A839B2HYS
NSC Number:
666096
Properties
Computed Properties
 
Complexity:
338  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
298.154g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
298.35g/mol
Monoisotopic Mass:
298.154g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
87.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5  

Synonyms
 
ethanol, 2-((9-methyl-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)- 
NSC-666096 
6A839B2HYS 
NCGC00025096-02 
NCGC00025096-03 
NCGC00025096-04 
NCGC00025096-05 
NCGC00025096-06 
NCGC00025096-07 
NCGC00261568-01 
CJ-26517 
NCI60_022916 
RT-014854 
CHEMBL280074 
EU-0100883 
FT-0642456 
ST50298830 
O 0886 
C-28477 
J-000453 
SR-01000075518-1 
SR-01000075518-3 
SR-01000075518-6 
BRD-K82731415-001-03-9 
2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol 
BRD-K82731415-001-04-7 
2-[[6-(benzylamino)-9-methyl-purin-2-yl]amino]ethanol 
2-({9-methyl-6-[benzylamino]purin-2-yl}amino)ethan-1-ol 
2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)ethanol 
6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine 
2-[[9-methyl-6-(phenylmethylamino)purin-2-yl]amino]ethanol 
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol 
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol 
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol, 9CI 
trans-Chalcone 
6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine 
D00BPA 
CID4592 
AR-1D7506 
C090046 
2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine 
ethanol, 2-((9-methyl-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)- 
100-25-4 
10214-40-1 
614-47-1 
6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine 
Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- 
2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine 
OLO 
6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine 
6-benzylamino-2-[2-hydroxyethylamino]-9-methylpurine 
olomoucine 
2-(2-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine 
2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol 
C15H18N6O 
2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol 
Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- 
SR-01000075518 
Olomucine 
purine deriv. 5 
NSC 666096 
NSC-666096 
olomoucine 
Kinome_2870 
Tocris-1284 
1w0x 
ACMC-20cp0o 
AC1L1IID 
AC1Q4XZU 
BiomolKI_000046 
Lopac-O-0886 
BiomolKI2_000052 
UPCMLD-DP136 
101622-51-9 
CBiol_002050 
Lopac0_000883 
BSPBio_000990 
KBioGR_000330 
KBioSS_000330 
SCHEMBL135056 
BDBM5718 
BMK1-E10 
2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine 
Olomoucine, >=98% (HPLC) 
4erk 
UPCMLD-DP136:001 
UPCMLD-DP136:002 
BCBcMAP01_000205 
CTK4A0020 
KBio2_000330 
KBio2_002898 
KBio2_005466 
KBio3_000659 
KBio3_000660 
BIO3107 
UNII-6A839B2HYS 
DTXSID90144068 
GTVPOLSIJWJJNY-UHFFFAOYSA-N 
ZX-AFC001655 
Bio1_000336 
Bio1_000825 
Bio1_001314 
Bio2_000335 
Bio2_000815 
HMS1362B11 
HMS1792B11 
MFCD00189360 
HMS1990B11 
HMS3262B08 
HMS3267L09 
HMS3403B11 
HMS3650F19 
HMS3676E10 
ZINC1641925 
Tox21_500883 
1966AH 
IN1179 
InSolution™ Olomoucine 
IN1182 
NSC666096 
AKOS005145988 
CCG-100650 
DB02116 
LP00883 
TRA0035611 
IDI1_002090 
SMP1_000281 
2,6,9-Trisubstituted purine deriv. 26 
2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine 
NCGC00015763-01 
NCGC00015763-02 
NCGC00015763-03 
NCGC00015763-04 
NCGC00015763-05 
NCGC00015763-06 
NCGC00015763-07 
NCGC00015763-08 
NCGC00015763-09 
NCGC00025096-01 
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Title: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.

Journal: European journal of biochemistry 20031201

Title: Changes in the activities of hydroxysteroid dehydrogenases in mouse oocytes during meiotic maturation.

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Title: Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells.

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Title: Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.

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Title: Prevention of dopaminergic neuronal death by cyclic AMP in mixed neuronal/glial mesencephalic cultures requires the repression of presumptive astrocytes.

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Title: Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells.

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Title: Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis.

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Title: Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials.

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Title: Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors.

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Title: The specificities of protein kinase inhibitors: an update.

Journal: The Biochemical journal 20030401

Title: Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH+-N7)Cl(3)].9/5H2O [Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine].

Journal: Journal of inorganic biochemistry 20030401

Title: Studies of the cell cycle of in vitro cultured skin fibroblasts in goats: work in progress.

Journal: Theriogenology 20030301

Title: Growth cones contain a dynamic population of neurofilament subunits.

Journal: Cell motility and the cytoskeleton 20030301

Title: Inhibition of nucleoside transport by protein kinase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20030201

Title: In vitro glycosidation potential towards olomoucine-type cyclin-dependent kinase inhibitors in rodent and primate microsomes.

Journal: Physiological research 20030101

Title: Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis.

Journal: The Journal of biological chemistry 20021213

Title: Synthesis and biological activity of olomoucine II.

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Title: Inducible DNA demethylation mediated by the maize Suppressor-mutator transposon-encoded TnpA protein.

Journal: The Plant cell 20021101

Title: Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future.

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Title: PCNA protein associates to Cdk-A type protein kinases in germinating maize.

Journal: Plant molecular biology 20020901

Title: Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition.

Journal: Developmental cell 20020901

Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: involvement of cyclin A.

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Title: M phase-specific expression and phosphorylation-dependent ubiquitination of the ClC-2 channel.

Journal: The Journal of biological chemistry 20020830

Title: Differential effects of cyclin-dependent kinase blockers upon cell death in the developing retina.

Journal: Brain research 20020823

Title: Two kinase activities are sufficient for sea urchin sperm chromatin decondensation in vitro.

Journal: Molecular reproduction and development 20020801

Title: Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.

Journal: Antimicrobial agents and chemotherapy 20020801

Title: Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.

Journal: Biochemical pharmacology 20020801

Title: Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines.

Journal: Molecular pathology : MP 20020801

Title: Mimosine prevents the death of glucose-deprived immunostimulated astrocytes by scavenging peroxynitrite.

Journal: Glia 20020701

Title: Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture.

Journal: Journal of neurochemistry 20020701

Title: Molecular mechanism of enhanced apoptotic response in U937 cells mediated by sodium butyrate.

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020701

Title: Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes.

Journal: Journal of medicinal chemistry 20020606

Title: Involvement of cyclin-dependent kinases in axotomy-induced retinal ganglion cell death.

Journal: The Journal of comparative neurology 20020520

Title: A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes.

Journal: Developmental biology 20020501

Title: Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase.

Journal: The Journal of physiology 20020501

Title: Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi.

Journal: Molecular and biochemical parasitology 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

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Title: Beta-carbolines as specific inhibitors of cyclin-dependent kinases.

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Title: The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity.

Journal: Neuroscience letters 20020405

Title: Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020401

Title: Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors.

Journal: British journal of pharmacology 20020401

Title: Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases.

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Title: A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication.

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Title: Comparison of the TUNEL, lamin B and annexin V methods for the detection of apoptosis by flow cytometry.

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Title: The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic.

Journal: EMBO reports 20011215

Title: Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis.

Journal: The Journal of biological chemistry 20011214

Title: Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase.

Journal: Neuroreport 20011204

Title: Cell cycle arrest allows centrin translation but not basal body formation during spermiogenesis in Marsilea.

Journal: Journal of cell science 20011201

Title: Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote.

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Title: Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells.

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Title: Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.

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Title: Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors.

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Title: Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010715

Title: Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle.

Journal: Immunology and cell biology 20010601

Title: Reversible nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase upon serum depletion.

Journal: European journal of cell biology 20010601

Title: Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support.

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Title: Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.

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Title: Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells.

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Title: Cell cycle in the fucus zygote parallels a somatic cell cycle but displays a unique translational regulation of cyclin-dependent kinases.

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Title: Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins.

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Title: Modulation of Sp1 activity by a cyclin A/CDK complex.

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Title: The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor.

Journal: Neuroscience letters 20010112

Title: Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation.

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Title: Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.

Journal: Genome biology 20010101

Title: 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.

Journal: Bioorganic & medicinal chemistry letters 20000306

Title: 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 19990104

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