Title: Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells.
Journal: Experimental cell research 20121001
Title: Role of trefoil factor 1 in gastric cancer and relationship between trefoil factor 1 and gastrokine 1.
Journal: Oncology reports 20121001
Title: Synthesis, biological evaluation, and molecular docking studies of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)aniline derivatives as novel anticancer agents.
Journal: Bioorganic & medicinal chemistry 20120815
Title: Co-ordination of cell cycle and differentiation in the developing nervous system.
Journal: The Biochemical journal 20120615
Title: Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma.
Journal: Acta neuropathologica 20120401
Title: Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone.
Journal: Pharmacological research 20120301
Title: Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.
Journal: Journal of cellular physiology 20120201
Title: Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
Journal: PloS one 20120101
Title: Polydendrocytes display large lineage plasticity following focal cerebral ischemia.
Journal: PloS one 20120101
Title: [Effect of inhibitors serine/threonine protein kinases and protein phosphatases on mitosis progression of synchronized tobacco by-2 cells].
Journal: TSitologiia i genetika 20120101
Title: Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors.
Journal: European journal of medicinal chemistry 20111201
Title: In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111101
Title: Transcriptional modulation of apoptosis regulators by roscovitine and related compounds.
Journal: Apoptosis : an international journal on programmed cell death 20110701
Title: Ibulocydine is a novel prodrug Cdk inhibitor that effectively induces apoptosis in hepatocellular carcinoma cells.
Journal: The Journal of biological chemistry 20110603
Title: Evidence for amylase release by cyclin-dependent kinase 5 in the rat parotid.
Journal: Archives of biochemistry and biophysics 20110315
Title: Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations.
Journal: Chemico-biological interactions 20110201
Title: Reconstitution of human MCF-7 breast cancer cells with caspase-3 does not sensitize them to action of CDK inhibitors.
Journal: Journal of cellular biochemistry 20110101
Title: Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
Journal: PloS one 20110101
Title: Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2.
Journal: PloS one 20110101
Title: Striatal signal transduction and drug addiction.
Journal: Frontiers in neuroanatomy 20110101
Title: Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product.
Journal: PloS one 20110101
Title: Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus.
Journal: International journal of endocrinology 20110101
Title: Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes.
Journal: Molecular neurodegeneration 20110101
Title: Predicting the possibility of two newly isolated phenetheren ring containing compounds from Aristolochia manshuriensis as CDK2 inhibitors.
Journal: Bioinformation 20110101
Title: Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2.
Journal: Toxicology 20101205
Title: Comparison of effects of protein kinase A, mitogen-activated protein kinase, and cyclin-dependent kinase blockers on rabbit ovarian granulosa cell functions.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.
Journal: European journal of medicinal chemistry 20100901
Title: Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine.
Journal: Investigational new drugs 20100601
Title: Previous stress exposure enhances both anxiety-like behaviour and p35 levels in the basolateral amygdala complex: modulation by midazolam.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100601
Title: Cytotoxic activities of several geranyl-substituted flavanones.
Journal: Journal of natural products 20100423
Title: Phosphorylation of TFIIB links transcription initiation and termination.
Journal: Current biology : CB 20100323
Title: Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors.
Journal: European journal of medicinal chemistry 20100301
Title: Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells.
Journal: Stem cells and development 20100201
Title: Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.
Journal: Melanoma research 20100201
Title: Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells.
Journal: Neuroscience letters 20100118
Title: The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.
Journal: Antiviral chemistry & chemotherapy 20100105
Title: Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.
Journal: European journal of medicinal chemistry 20100101
Title: The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors.
Journal: Neoplasma 20100101
Title: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors.
Journal: AIDS research and therapy 20100101
Title: Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.
Journal: Advances in pharmacological sciences 20100101
Title: Cell cycle inhibitor enhances the resolution of HSV-1-induced proinflammatory response in murine microglial cells.
Journal: Neurological research 20091101
Title: MAP kinase dependent cyclinE/cdk2 activity promotes DNA replication in early sea urchin embryos.
Journal: Developmental biology 20091015
Title: Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.
Journal: Molecular pharmacology 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: The influence of bioactive oxylipins from marine diatoms on invertebrate reproduction and development.
Journal: Marine drugs 20090901
Title: The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5.
Journal: Journal of neurochemistry 20090801
Title: Is olomoucine, a weak CDK2 inhibitor, able to induce apoptosis in cancer cells?
Journal: Annals of the New York Academy of Sciences 20090801
Title: Interactions of olomoucine II with human liver microsomal cytochromes P450.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090601
Title: Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine.
Journal: Journal of cellular biochemistry 20090601
Title: Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine.
Journal: Brain research 20090406
Title: Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB.
Journal: Cell proliferation 20090401
Title: A cell cycle timer for asymmetric spindle positioning.
Journal: PLoS biology 20090401
Title: The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease.
Journal: Aging 20090401
Title: Molecular pathology of neuro-AIDS (CNS-HIV).
Journal: International journal of molecular sciences 20090301
Title: ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.
Journal: Bioorganic & medicinal chemistry 20090201
Title: Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.
Journal: Pharmaceutical research 20090201
Title: Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease.
Journal: Frontiers in molecular neuroscience 20090101
Title: Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase.
Journal: Cell division 20090101
Title: CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
Journal: The Journal of biological chemistry 20081219
Title: Hydrolytic cleavage of N6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases.
Journal: Bioscience reports 20081201
Title: Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201
Title: Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells.
Journal: Biochemical pharmacology 20081201
Title: BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis.
Journal: Molecular cancer therapeutics 20081201
Title: Distinct functions of Cdk5(Y15) phosphorylation and Cdk5 activity in stress fiber formation and organization.
Journal: Experimental cell research 20081115
Title: Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080801
Title: Rat focal cerebral ischemia induced astrocyte proliferation and delayed neuronal death are attenuated by cyclin-dependent kinase inhibition.
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20080301
Title: Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
Journal: The EMBO journal 20080109
Title: Maize D4;1 and D5 cyclin proteins in germinating maize. Associated kinase activity and regulation by phytohormones.
Journal: Physiologia plantarum 20080101
Title: The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo.
Journal: Molecular vision 20080101
Title: Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways.
Journal: AIDS research and therapy 20080101
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein.
Journal: Journal of cellular biochemistry 20071215
Title: [Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20071001
Title: [Effects of cyclin dependent protein kinase inhibitor olomoucine on the neuronal apoptosis after status epilepticus: experiment with rats].
Journal: Zhonghua yi xue za zhi 20070807
Title: Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model.
Journal: Brain research 20070618
Title: The role of ghrelin and some intracellular mechanisms in controlling the secretory activity of chicken ovarian cells.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070501
Title: Cell cycle inhibition and retinoblastoma protein overexpression prevent Purkinje cell death in organotypic slice cultures.
Journal: Developmental neurobiology 20070501
Title: Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells.
Journal: Journal of cellular biochemistry 20070415
Title: Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo.
Journal: Glia 20070401
Title: Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats.
Journal: Brain research 20070302
Title: Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.
Journal: The Journal of biological chemistry 20070302
Title: Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5.
Journal: Experimental and molecular pathology 20070201
Title: A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days.
Journal: British journal of cancer 20070115
Title: A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport.
Journal: Endocrinology 20070101
Title: Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice.
Journal: Journal of brachial plexus and peripheral nerve injury 20070101
Title: Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses.
Journal: Molecular vision 20070101
Title: 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Journal: Journal of medicinal chemistry 20061102
Title: Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine.
Journal: Journal of neuroscience research 20061001
Title: p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study.
Journal: Cellular and molecular life sciences : CMLS 20061001
Title: Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia.
Journal: Biochemical and biophysical research communications 20060818
Title: Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53.
Journal: Cancer gene therapy 20060801
Title: Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors.
Journal: Molecular neurobiology 20060801
Title: Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons.
Journal: Life sciences 20060627
Title: The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction.
Journal: The European journal of neuroscience 20060601
Title: An efficient direct amination of cyclic amides and cyclic ureas.
Journal: Organic letters 20060525
Title: [Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats].
Journal: Zhonghua yi xue za zhi 20060404
Title: The role of protein kinase A and cyclin-dependent (CDC2) kinase in the control of basal and IGF-II-induced proliferation and secretory activity of chicken ovarian cells.
Journal: Animal reproduction science 20060301
Title: Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.
Journal: Cell cycle (Georgetown, Tex.) 20060301
Title: Selectivity and potency of cyclin-dependent kinase inhibitors.
Journal: The AAPS journal 20060301
Title: Analysis on heat stress-induced hyperphosphorylation of stathmin at serine 37 in Jurkat cells by means of two-dimensional gel electrophoresis and tandem mass spectrometry.
Journal: Journal of chromatography. A 20060217
Title: Zinc(II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity.
Journal: Journal of inorganic biochemistry 20060201
Title: Nitric oxide modulates the expression of cell cycle regulatory genes during lateral root formation in tomato.
Journal: Journal of experimental botany 20060101
Title: Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of the novel anticancer agent 17-DMAG in human plasma.
Journal: Rapid communications in mass spectrometry : RCM 20060101
Title: Cyclin-dependent kinase (CDK) inhibitor olomoucine enhances gamma-irradiation-induced apoptosis and cell cycle arrest in Raji cells.
Journal: Anticancer research 20060101
Title: Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes.
Journal: Toxicology 20051215
Title: Molecular models of protein kinase 6 from Plasmodium falciparum.
Journal: Journal of molecular modeling 20051201
Title: Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs.
Journal: European journal of pharmacology 20051107
Title: Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.
Journal: Journal of medicinal chemistry 20051103
Title: Cdk2 activity is dispensable for triggering replicon initiation after transient hypoxia in T24 cells.
Journal: The FEBS journal 20051101
Title: During male pronuclei formation chromatin remodeling is uncoupled from nucleus decondensation.
Journal: Journal of cellular biochemistry 20051001
Title: Cdk5-dependent regulation of glucose-stimulated insulin secretion.
Journal: Nature medicine 20051001
Title: Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.
Journal: Biophysical journal 20050901
Title: Role of the cell cycle in the pathobiology of central nervous system trauma.
Journal: Cell cycle (Georgetown, Tex.) 20050901
Title: DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells.
Journal: Journal of Alzheimer's disease : JAD 20050901
Title: Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.
Journal: Cellular and molecular life sciences : CMLS 20050801
Title: In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050701
Title: Signaling pathways in ascidian oocyte maturation: effects of various inhibitors and activators on germinal vesicle breakdown.
Journal: Development, growth & differentiation 20050501
Title: Resveratrol-induced apoptotic death in human U251 glioma cells.
Journal: Molecular cancer therapeutics 20050401
Title: Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response.
Journal: Cancer research 20050201
Title: CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.
Journal: The Journal of biological chemistry 20050128
Title: Clinical anticancer drug development: targeting the cyclin-dependent kinases.
Journal: British journal of cancer 20050117
Title: Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration.
Journal: Sub-cellular biochemistry 20050101
Title: Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways.
Journal: Breast cancer research : BCR 20050101
Title: N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
Journal: The Journal of biological chemistry 20041112
Title: A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors.
Journal: Journal of medicinal chemistry 20041021
Title: Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle.
Journal: The Journal of biological chemistry 20040917
Title: Mitogen-activated protein kinase regulates neurofilament axonal transport.
Journal: Journal of cell science 20040915
Title: Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.
Journal: The American journal of pathology 20040901
Title: Cdk5 regulates activation and localization of Src during corneal epithelial wound closure.
Journal: Journal of cell science 20040815
Title: Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040707
Title: A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons.
Journal: The EMBO journal 20040602
Title: Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons.
Journal: Biochemical pharmacology 20040515
Title: Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs.
Journal: Experimental cell research 20040415
Title: Xylocydine, a novel inhibitor of cyclin-dependent kinases, prevents the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic cell death of SK-HEP-1 cells.
Journal: The Journal of pharmacology and experimental therapeutics 20040301
Title: Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.
Journal: Journal of biomolecular screening 20040301
Title: Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis.
Journal: Molecular cancer therapeutics 20040301
Title: Activation of cyclin-dependent kinase 5 is involved in axonal regeneration.
Journal: Molecular and cellular neurosciences 20040301
Title: Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.
Journal: Journal of cell science 20040215
Title: Protection of renal cells from cisplatin toxicity by cell cycle inhibitors.
Journal: American journal of physiology. Renal physiology 20040201
Title: Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5.
Journal: Journal of cellular biochemistry 20040201
Title: Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.
Journal: Oncology 20040101
Title: Cell cycle arrest induced in human breast cancer cells by cyclin-dependent kinase inhibitors: a comparison of the effects exerted by roscovitine and olomoucine.
Journal: Polish journal of pharmacology 20040101
Title: Synergic effects of the cyclin-dependent kinase (CDK) inhibitor olomoucine and androgen-antagonist bicalutamide on prostatic cancer cell lines.
Journal: Neoplasma 20040101
Title: An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis.
Journal: Journal of cell science 20031215
Title: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.
Journal: European journal of biochemistry 20031201
Title: Changes in the activities of hydroxysteroid dehydrogenases in mouse oocytes during meiotic maturation.
Journal: The Journal of reproduction and development 20031201
Title: Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells.
Journal: Molecular and cellular neurosciences 20031101
Title: Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20030915
Title: Prevention of dopaminergic neuronal death by cyclic AMP in mixed neuronal/glial mesencephalic cultures requires the repression of presumptive astrocytes.
Journal: Molecular pharmacology 20030901
Title: Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells.
Journal: Brain research. Molecular brain research 20030819
Title: Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis.
Journal: Biochemical and biophysical research communications 20030613
Title: Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials.
Journal: Accounts of chemical research 20030601
Title: Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors.
Journal: European journal of medicinal chemistry 20030501
Title: The specificities of protein kinase inhibitors: an update.
Journal: The Biochemical journal 20030401
Title: Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH+-N7)Cl(3)].9/5H2O [Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine].
Journal: Journal of inorganic biochemistry 20030401
Title: Studies of the cell cycle of in vitro cultured skin fibroblasts in goats: work in progress.
Journal: Theriogenology 20030301
Title: Growth cones contain a dynamic population of neurofilament subunits.
Journal: Cell motility and the cytoskeleton 20030301
Title: Inhibition of nucleoside transport by protein kinase inhibitors.
Journal: The Journal of pharmacology and experimental therapeutics 20030201
Title: In vitro glycosidation potential towards olomoucine-type cyclin-dependent kinase inhibitors in rodent and primate microsomes.
Journal: Physiological research 20030101
Title: Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis.
Journal: The Journal of biological chemistry 20021213
Title: Synthesis and biological activity of olomoucine II.
Journal: Bioorganic & medicinal chemistry letters 20021118
Title: Inducible DNA demethylation mediated by the maize Suppressor-mutator transposon-encoded TnpA protein.
Journal: The Plant cell 20021101
Title: Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future.
Journal: Current topics in medicinal chemistry 20020901
Title: PCNA protein associates to Cdk-A type protein kinases in germinating maize.
Journal: Plant molecular biology 20020901
Title: Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition.
Journal: Developmental cell 20020901
Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: involvement of cyclin A.
Journal: Toxicology and applied pharmacology 20020901
Title: M phase-specific expression and phosphorylation-dependent ubiquitination of the ClC-2 channel.
Journal: The Journal of biological chemistry 20020830
Title: Differential effects of cyclin-dependent kinase blockers upon cell death in the developing retina.
Journal: Brain research 20020823
Title: Two kinase activities are sufficient for sea urchin sperm chromatin decondensation in vitro.
Journal: Molecular reproduction and development 20020801
Title: Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.
Journal: Antimicrobial agents and chemotherapy 20020801
Title: Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.
Journal: Biochemical pharmacology 20020801
Title: Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines.
Journal: Molecular pathology : MP 20020801
Title: Mimosine prevents the death of glucose-deprived immunostimulated astrocytes by scavenging peroxynitrite.
Journal: Glia 20020701
Title: Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture.
Journal: Journal of neurochemistry 20020701
Title: Molecular mechanism of enhanced apoptotic response in U937 cells mediated by sodium butyrate.
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020701
Title: Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes.
Journal: Journal of medicinal chemistry 20020606
Title: Involvement of cyclin-dependent kinases in axotomy-induced retinal ganglion cell death.
Journal: The Journal of comparative neurology 20020520
Title: A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes.
Journal: Developmental biology 20020501
Title: Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase.
Journal: The Journal of physiology 20020501
Title: Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi.
Journal: Molecular and biochemical parasitology 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Beta-carbolines as specific inhibitors of cyclin-dependent kinases.
Journal: Bioorganic & medicinal chemistry letters 20020408
Title: The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity.
Journal: Neuroscience letters 20020405
Title: Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020401
Title: Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors.
Journal: British journal of pharmacology 20020401
Title: Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases.
Journal: Leukemia 20020301
Title: A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication.
Journal: The Journal of biological chemistry 20020222
Title: Sensitivity of the origin decision point to specific inhibitors of cellular signaling and metabolism.
Journal: Experimental cell research 20020201
Title: Sequential expression patterns of apoptosis- and cell cycle-related proteins in neuronal response to severe or mild transient hypoxia.
Journal: Neuroscience 20020101
Title: Comparison of the TUNEL, lamin B and annexin V methods for the detection of apoptosis by flow cytometry.
Journal: Acta histochemica 20020101
Title: The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic.
Journal: EMBO reports 20011215
Title: Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis.
Journal: The Journal of biological chemistry 20011214
Title: Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase.
Journal: Neuroreport 20011204
Title: Cell cycle arrest allows centrin translation but not basal body formation during spermiogenesis in Marsilea.
Journal: Journal of cell science 20011201
Title: Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote.
Journal: Development (Cambridge, England) 20011101
Title: Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells.
Journal: Oncogene 20010920
Title: Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.
Journal: Biochemical pharmacology 20010801
Title: Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors.
Journal: Journal of virology 20010801
Title: Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010715
Title: Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle.
Journal: Immunology and cell biology 20010601
Title: Reversible nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase upon serum depletion.
Journal: European journal of cell biology 20010601
Title: Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support.
Journal: The Journal of biological chemistry 20010323
Title: Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
Journal: Nature 20010315
Title: Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells.
Journal: Oncogene 20010308
Title: Cell cycle in the fucus zygote parallels a somatic cell cycle but displays a unique translational regulation of cyclin-dependent kinases.
Journal: The Plant cell 20010301
Title: Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins.
Journal: Molecular and biochemical parasitology 20010301
Title: Modulation of Sp1 activity by a cyclin A/CDK complex.
Journal: Journal of molecular biology 20010216
Title: The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor.
Journal: Neuroscience letters 20010112
Title: Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation.
Journal: European journal of pharmacology 20010105
Title: Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.
Journal: Genome biology 20010101
Title: 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.
Journal: Bioorganic & medicinal chemistry letters 20000306
Title: 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 19990104
Title: Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994).
Title: Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83(2), 105-120 (1995).
Title: Hajdúch M, et al. Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine. Anticancer Drugs. 1997 Nov. 8(10):1007-13.
Title: Raynaud FI, et al. Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. Mol Cancer Ther. 2004 Mar. 3(3):353-62.
101975-10-4 | 3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]- | AA00061Q | MFCD00867059
102636-82-8 | 1-Propanaminium, 3-carboxy-2-(4-carboxy-1-oxobutoxy)-N,N,N-trimethyl-, inner salt, (2R)- | AA0007X2 | MFCD16036250