Title: A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.
Journal: Genes & development 20150915
Title: 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.
Journal: Journal of medicinal chemistry 20130822
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.
Journal: Organic & biomolecular chemistry 20120907
Title: Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.
Journal: Bioorganic & medicinal chemistry letters 20120901
Title: Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.
Journal: Cancer chemotherapy and pharmacology 20120101
Title: Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.
Journal: Organic & biomolecular chemistry 20110907
Title: DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.
Journal: Molecular pharmacology 20110801
Title: DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.
Journal: Bioorganic & medicinal chemistry letters 20110201
Title: Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia.
Journal: British journal of haematology 20110101
Title: Targeting the DNA double strand break repair machinery in prostate cancer.
Journal: PloS one 20110101
Title: Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100615
Title: Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation.
Journal: International journal of radiation oncology, biology, physics 20091201
Title: 8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).
Journal: Bioorganic & medicinal chemistry letters 20080901
Title: DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080615
Title: Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase inhibitors.
Journal: Organic letters 20061221
Title: Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
Journal: Cancer research 20060515
Title: Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.
Journal: Biochemical pharmacology 20051219
Title: Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Journal: Journal of medicinal chemistry 20051201
Title: Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
Journal: Bioorganic & medicinal chemistry letters 20041220
Title: The DNA-dependent protein kinase.
Journal: Genes & development 19990415
Title: Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 19970701
Title: Differential implications of the oncogene-tumor suppressor gene complex in the geneses of 19 human neoplasias. Evidence in support of the steroid carcinogenesis hypothesis.
Journal: Anticancer research 19970101
Title: Justin J J Leahy, et al. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7.
Title: Yang C, et al. NU7441 Enhances the Radiosensitivity of Liver Cancer Cells. Cell Physiol Biochem. 2016;38(5):1897-905
Title: Hardcastle IR, et al. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46
Title: Ember SW, et al. The acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. ACS Chem Biol. 2014 Feb 25.
Title: Robert F, et al. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015 Aug 27;7:93
