52906-92-0,MFCD00076521
Catalog No.:AA00D85O

52906-92-0 | MOTILIN (HUMAN, PORCINE)

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1mg
95%
1 week  
$317.00   $222.00
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2mg
95%
1 week  
$535.00   $375.00
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5mg
95%
1 week  
$924.00   $647.00
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10mg
95%
1 week  
$1,269.00   $888.00
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25mg
95%
1 week  
$1,863.00   $1,304.00
- +
50mg
95%
1 week  
$2,492.00   $1,744.00
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100mg
95%
1 week  
$3,338.00   $2,336.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00D85O
Chemical Name:
MOTILIN (HUMAN, PORCINE)
CAS Number:
52906-92-0
Molecular Formula:
C120H188N34O35S
Molecular Weight:
2699.0485
MDL Number:
MFCD00076521
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CCC(=O)N)CCCCN)CC(=O)N)CCCNC(=N)N)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)N)Cc1ccccc1)Cc1ccc(cc1)O)CCC(=O)O)CC(C)C)CCC(=O)N)CCCNC(=N)N)CCSC)CCC(=O)N)CCC(=O)O
Properties
Computed Properties
 
Complexity:
6010  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
22  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
190  
Hydrogen Bond Acceptor Count:
41  
Hydrogen Bond Donor Count:
39  
Isotope Atom Count:
0  
Rotatable Bond Count:
95  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-14  

Literature

Title: The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin.

Journal: British journal of pharmacology 20130401

Title: Can small non-peptide motilin agonists force a breakthrough as gastroprokinetic drugs?

Journal: British journal of pharmacology 20121001

Title: Acute effects of different glycemic index diets on serum motilin, orexin and neuropeptide Y concentrations in healthy individuals.

Journal: Neuropeptides 20120601

Title: Gastrointestinal hormone concentrations associated with gastric feeding in critically ill patients.

Journal: JPEN. Journal of parenteral and enteral nutrition 20120301

Title: A new strategy for metabolic stabilization of motilin using the C-terminal part of ghrelin.

Journal: Peptides 20120201

Title: Transcription factor binding site polymorphism in the motilin gene associated with left-sided displacement of the abomasum in German Holstein cattle.

Journal: PloS one 20120101

Title: Influence of acute exposure to high altitude on basal and postprandial plasma levels of gastroenteropancreatic peptides.

Journal: PloS one 20120101

Title: Myenteric neural network activated by motilin in the stomach of Suncus murinus (house musk shrew).

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111201

Title: [Long-term efficacy and safety research on functional dyspepsia treated with electroacupuncture and Zhizhu Kuanzhong capsule].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20111201

Title: [Effects of transcutaneous electrical acupoint stimulation combined with general anesthesia on changes of gastric dynamics in controlled hypotension dogs].

Journal: Zhen ci yan jiu = Acupuncture research 20111201

Title: Motilin stimulates preadipocyte proliferation and differentiation and adipocyte lipid storage.

Journal: American journal of physiology. Endocrinology and metabolism 20111101

Title: The paraventricular nucleus modulates thyroidal motilin release and rat gastric motility.

Journal: Journal of neuroendocrinology 20110901

Title: Lactulose in fat-free milk, rather than increased ghrelin and motilin level, might help for solving constipation: author update.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20110601

Title: Simotang enhances gastrointestinal motility, motilin and cholecystokinin expression in chronically stressed mice.

Journal: World journal of gastroenterology 20110328

Title: Effect of ginger on gastric motility and symptoms of functional dyspepsia.

Journal: World journal of gastroenterology 20110107

Title: Effect of ω-3 fatty acid on gastrointestinal motility after abdominal operation in rats.

Journal: Mediators of inflammation 20110101

Title: Comparison of the effects of pantethine and fursultiamine on plasma gastrointestinal peptide levels in healthy volunteers.

Journal: Biological & pharmaceutical bulletin 20110101

Title: 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus).

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101001

Title: Pharmacologic management of chronic constipation.

Journal: Gastroenterology clinics of North America 20100901

Title: Endogenous gastric mediators: patho-physiological role and measurements.

Journal: Current protocols in toxicology 20100801

Title: Mechanism of interdigestive migrating motor complex in conscious dogs.

Journal: Journal of gastroenterology 20100501

Title: Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats.

Journal: Acta physiologica (Oxford, England) 20100501

Title: Colitis affects the smooth muscle and neural response to motilin in the rabbit antrum.

Journal: British journal of pharmacology 20100101

Title: Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety.

Journal: Journal of medicinal chemistry 20091112

Title: [Promotility drugs use in critical care: indications and limits?].

Journal: Annales francaises d'anesthesie et de reanimation 20091101

Title: Emerging drugs for chronic constipation.

Journal: Expert opinion on emerging drugs 20090901

Title: An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying.

Journal: European journal of pharmacology 20090801

Title: Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats.

Journal: Regulatory peptides 20090605

Title: GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090601

Title: Prokinetic drugs for feed intolerance in critical illness: current and potential therapies.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20090601

Title: [Clinical observation on transcutaneous electrical acupoint stimulation for treatment of functional dyspepsia].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20090601

Title: Effect of TZP-201, a novel motilin receptor antagonist, in the colon of the musk shrew (Suncus murinus).

Journal: The Journal of pharmacy and pharmacology 20090301

Title: Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.

Journal: Journal of medicinal chemistry 20090226

Title: An immunocytochemical study of the endocrine cells in the stomach and duodenum of Zonotrichia capensis subtorquata (Passeriformes, Emberizidae).

Journal: Acta histochemica 20090101

Title: Current treatment of nausea and vomiting associated with gastroparesis: antiemetics, prokinetics, tricyclics.

Journal: Gastrointestinal endoscopy clinics of North America 20090101

Title: Predictors of gastric myoelectrical activity in type 2 diabetes mellitus.

Journal: Journal of clinical gastroenterology 20090101

Title: Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome.

Journal: Expert opinion on investigational drugs 20081101

Title: A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20080901

Title: Effect of ileal infusion of short-chain fatty acids on pancreatic prandial secretion and gastrointestinal hormones in pigs.

Journal: Pancreas 20080801

Title: Effect of motilin on the discharge of rat hippocampal neurons responding to gastric distension and its potential mechanism.

Journal: Peptides 20080401

Title: Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits.

Journal: European journal of pharmacology 20080310

Title: Mutational analysis of predicted intracellular loop domains of human motilin receptor.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080201

Title: Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin.

Journal: General and comparative endocrinology 20080101

Title: Effects of motilin and mitemcinal (GM-611) on gastrointestinal contractile activity in rhesus monkeys in vivo and in vitro.

Journal: Digestive diseases and sciences 20071101

Title: Emerging drugs for postoperative ileus.

Journal: Expert opinion on emerging drugs 20071101

Title: Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits.

Journal: Journal of gastroenterology and hepatology 20071001

Title: A comparison study between early enteral nutrition and parenteral nutrition in severe burn patients.

Journal: Burns : journal of the International Society for Burn Injuries 20070901

Title: Distribution and electrophysiological effects of motilin in Purkinje cells.

Journal: Neuroreport 20070827

Title: [Physiological effects of cold and cool Chinese herbal medicine of channel tropism of stomach on rats with stomach-heat syndrome].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

Title: Effect of acupuncture at Foot-Yangming Meridian on gastric mucosal blood flow, gastric motility and brain-gut peptide.

Journal: World journal of gastroenterology 20070421

Title: Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070401

Title: Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro.

Journal: British journal of pharmacology 20070201

Title: Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs.

Journal: Inflammopharmacology 20070201

Title: Therapeutic strategies for the management of delayed gastric emptying after pancreatic resection.

Journal: Langenbeck's archives of surgery 20070101

Title: Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs.

Journal: Pharmacology 20070101

Title: Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20061201

Title: [Effects of acute hypobaric hypoxia on gastric emptying and intestinal propulsion: experiment with rats].

Journal: Zhonghua yi xue za zhi 20060912

Title: [Clinicopharmacological study of gastrointestinal drugs from the viewpoint of postmarketing development].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060901

Title: [Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060901

Title: [Regulative effect of leptin on gastric motility: experiment with conscious rats].

Journal: Zhonghua yi xue za zhi 20060829

Title: Intragastric acidification inhibits motilin-induced phase III activity in humans.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20060801

Title: Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy.

Journal: European journal of endocrinology 20060701

Title: Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man.

Journal: European journal of clinical investigation 20060701

Title: [Effects of intra-amygdaloid injection of motilin on the interdigestive migrating myoelectrical complex in rat].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060701

Title: Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.

Journal: The Journal of biological chemistry 20060505

Title: Clinical application of an enzyme immunoassay for cholecystokinin-like immunoreactive substance for determination of the human plasma levels: the effect of metoclopramide on gastrointestinal peptides and stress-related hormones.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20060501

Title: [Effect of motilin on intracellular free calcium of antral smooth muscle cells and its mechanisms].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060501

Title: Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways.

Journal: The American journal of gastroenterology 20060401

Title: Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus.

Journal: Metabolism: clinical and experimental 20060301

Title: Effects of pirenzepine on Dai-kenchu-to-induced elevation of the plasma neuropeptide levels in humans.

Journal: Biological & pharmaceutical bulletin 20060101

Title: Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects.

Journal: Pharmacology 20060101

Title: A motilin agonist, erythromycin, decreases circulating growth hormone levels in normal subjects but not in diabetic subjects.

Journal: Journal of diabetes and its complications 20060101

Title: Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population.

Journal: Neuroscience research 20051201

Title: Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon.

Journal: European journal of pharmacology 20051107

Title: Small intestinal manometry in patients with systemic sclerosis.

Journal: European journal of gastroenterology & hepatology 20051101

Title: Preproghrelin Leu72Met polymorphism in obese Korean children.

Journal: Journal of pediatric endocrinology & metabolism : JPEM 20051101

Title: Basic and clinical pharmacology of new motility promoting agents.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051001

Title: [Effects of acupuncture on the gastric motivity in patients with functional dyspepsia].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20051001

Title: Regulation of vascular reactivity by established and emerging GPCRs.

Journal: Trends in pharmacological sciences 20050901

Title: Effects of domperidone on human plasma levels of motilin, somatostatin, gastrin, adrenocorticotropic hormone and cortisol.

Journal: Biological & pharmaceutical bulletin 20050901

Title: [Distribution and role of motilin receptor in the amygdala of rats].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050901

Title: Effect of erythromycin on gastric dysmotility and neuroendocrine peptides in rats with diabetes mellitus.

Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20050901

Title: [Effects of intrahippocampal microinjection of motilin on interdigestive migrating myoelectrical complexes of rat duodenum].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050801

Title: Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: Ecabet sodium raises plasma levels of calcitonin generelated peptide and substance P in healthy humans.

Journal: The Journal of pharmacy and pharmacology 20050601

Title: [Measurements and significance of serum gastrin, plasma motilin and serum beta-endorphin in patients with severe burns].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20050601

Title: Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.

Journal: European journal of pharmacology 20050516

Title: Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes.

Journal: Clinical biochemistry 20050501

Title: Excitatory actions of motilin on myenteric neurons of the guinea-pig small intestine.

Journal: Autonomic neuroscience : basic & clinical 20050331

Title: Omeprazole raises somatostatin and motilin in human plasma.

Journal: Biological & pharmaceutical bulletin 20050201

Title: Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus.

Journal: Regulatory peptides 20050115

Title: Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050101

Title: Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20050101

Title: Effect of environmental hyperthermia on gastrin, somatostatin and motilin in rat ulcerated antral mucosa.

Journal: World journal of gastroenterology 20041201

Title: Effects of motilin and ursodeoxycholic acid on gastrointestinal myoelectric activity of different origins in fasted rats.

Journal: World journal of gastroenterology 20040901

Title: Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis.

Journal: Alimentary pharmacology & therapeutics 20040801

Title: Relationship between intraduodenal 5-hydroxytryptamine release and interdigestive contractions in dogs.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20040601

Title: Discovery of a potent and novel motilin agonist.

Journal: Journal of medicinal chemistry 20040325

Title: Neuromodulation of experimental Shigella infection reduces damage to the gut mucosa.

Journal: Microbes and infection 20040301

Title: Screening of a large panel of gastrointestinal peptide plasma levels is not adapted for the evaluation of digestive damage following irradiation.

Journal: Canadian journal of physiology and pharmacology 20040201

Title: Autonomic neuropathy and gastrointestinal motility disorders in children and adolescents with type 1 diabetes mellitus.

Journal: Journal of pediatric gastroenterology and nutrition 20040101

Title: Quantitative determination of the polypeptide motilin in rat plasma by externally calibrated liquid chromatography/electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: [Clinical observation on treatment of gastro-esophageal reflux with modified zhizhu pill].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040101

Title: Effect of motilin on endogenous release of insulin in conscious dogs in the fed state.

Journal: Digestive diseases and sciences 20031201

Title: Excitatory effects of motilin in the hippocampus on gastric motility in rats.

Journal: Brain research 20030912

Title: Gastrointestinal motility disorders and gastrointestinal prokinetic therapy.

Journal: The Veterinary clinics of North America. Small animal practice 20030901

Title: [Effect of motilin on gastric smooth contraction induced by interstitial cells of Cajal].

Journal: Zhonghua yi xue za zhi 20030825

Title: Intestinal aspects of cholesterol gallstone formation.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20030701

Title: Motilin-bicelle interactions: membrane position and translational diffusion.

Journal: FEBS letters 20030619

Title: Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20030401

Title: [Synthetic studies of microbial natural products from microorganisms].

Journal: The Japanese journal of antibiotics 20030201

Title: The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?

Journal: Regulatory peptides 20021231

Title: Motilin regulates interdigestive gastric blood flow in dogs.

Journal: Gastroenterology 20021101

Title: (13)C-(1)H NMR relaxation and fluorescence anisotropy decay study of tyrosine dynamics in motilin.

Journal: Biophysical journal 20021101

Title: Atropine-induced gastric dysrhythmia is not normalized by electroacupuncture.

Journal: Digestive diseases and sciences 20021101

Title: The structure of erythromycin enol ether as a model for its activity as a motilide.

Journal: Journal of medicinal chemistry 20021024

Title: Intraduodenal capsaicin inhibits gastric migrating motor complex via an extrinsic neural reflex in conscious dogs.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20021001

Title: A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.

Journal: The Journal of clinical endocrinology and metabolism 20020801

Title: [Effect of jianpi wenshen decoction on serum gastrin, plasma motilin and somatostatin in patients of diabetic diarrhea].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20020801

Title: [The other gastrointestinal hormones in diabetes mellitus].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020701

Title: Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats.

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020701

Title: Design and synthesis of novel tetra-peptide motilin agonists.

Journal: Bioorganic & medicinal chemistry 20020601

Title: In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020601

Title: The motilin pharmacophore in CHO cells expressing the human motilin receptor.

Journal: Biochemical and biophysical research communications 20020517

Title: Effects of motilin on human interdigestive gastrointestinal and gallbladder motility, and involvement of 5HT3 receptors.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020401

Title: Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. Critical role of second extracellular loop for peptide binding and action.

Journal: The Journal of biological chemistry 20020322

Title: Potentiation of motilin-induced contraction by nitric oxide synthase inhibition in the isolated chicken gastrointestinal tract.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020201

Title: Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin.

Journal: Journal of medicinal chemistry 20020131

Title: Effect of erythromycin on gastroduodenal contractile activity in developing neonates.

Journal: Journal of pediatric gastroenterology and nutrition 20020101

Title: Effects of adjustable gastric banding on altered gut neuropeptide levels in morbidly obese patients.

Journal: Obesity surgery 20011201

Title: Pressure-geometry relationship in the antroduodenal region in humans.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20011101

Title: Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.

Journal: The Journal of biological chemistry 20010921

Title: Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial.

Journal: Gut 20010901

Title: Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin.

Journal: Biological & pharmaceutical bulletin 20010901

Title: Gastric myoelectrical activity and gut hormone secretion in myotonic dystrophy.

Journal: European journal of gastroenterology & hepatology 20010701

Title: The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

Journal: European journal of pharmacology 20010629

Title: Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs.

Journal: Digestive diseases and sciences 20010601

Title: Interdigestive gallbladder emptying, antroduodenal motility, and motilin release patterns are altered in cholesterol gallstone patients.

Journal: Digestive diseases and sciences 20010601

Title: Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.

Journal: Brain research 20010323

Title: Effect of duodenectomy on gastric motility and gastric hormones in dogs.

Journal: Annals of surgery 20010301

Title: Contractile effects and intracellular Ca2+ signalling induced by motilin and erythromycin in the circular smooth muscle of human colon.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20010201

Title: Immunohistochemical study of the distribution of endocrine cells in the gastrointestinal tract of the camel (Camelus bactrianus).

Journal: European journal of morphology 20010201

Title: Growth hormone secretagogue receptor family members and ligands.

Journal: Endocrine 20010201

Title: Design and synthesis of N-terminal cyclic motilin partial peptides: a novel pure motilin antagonist.

Journal: Chemical & pharmaceutical bulletin 20010101

Title: Effects of intraduodenal bile on interdigestive gastrointestinal and gallbladder motility in healthy subjects.

Journal: Digestion 20010101

Title: Discovery of the first non-peptide antagonist of the motilin receptor.

Journal: Drug design and discovery 20010101

Title: Gastroprokinetic effect and mechanism of SK-896, a new motilin analogue, during the interdigestive period in conscious dogs.

Journal: Pharmacology 20010101

Title: Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: a pilot study.

Journal: Digestion 20010101

Title: Motilin and motilin receptors: characterization and functional significance.

Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20010101

Title: An unusual metastatic motilin-secreting neuroendocrine tumour with a 20-year survival. Pathological, biochemical and motility features.

Journal: Digestion 20010101

Title: Receptor for motilin identified in the human gastrointestinal system.

Journal: Science (New York, N.Y.) 19990625

Title: Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum.

Journal: Clinical and experimental pharmacology & physiology 19990301

Title: GM-109: a novel, selective motilin receptor antagonist in the smooth muscle of the rabbit small intestine.

Journal: The Journal of pharmacology and experimental therapeutics 19950501

Title: Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones.

Journal: Life sciences 19940101

Title: Coulie B, et al. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J Biol Chem. 2001 Sep 21;276(38):35518-22. Epub 2001 Jul 18.

Title: Huang J, et al. Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G23-31.

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Tags:52906-92-0 Molecular Formula|52906-92-0 MDL|52906-92-0 SMILES|52906-92-0 MOTILIN (HUMAN, PORCINE)
Catalog No.: AA00D85O
52906-92-0,MFCD00076521
52906-92-0 | MOTILIN (HUMAN, PORCINE)
Pack Size: 1mg
Purity: 95%
1 week
$317.00 $222.00
Pack Size: 2mg
Purity: 95%
1 week
$535.00 $375.00
Pack Size: 5mg
Purity: 95%
1 week
$924.00 $647.00
Pack Size: 10mg
Purity: 95%
1 week
$1,269.00 $888.00
Pack Size: 25mg
Purity: 95%
1 week
$1,863.00 $1,304.00
Pack Size: 50mg
Purity: 95%
1 week
$2,492.00 $1,744.00
Pack Size: 100mg
Purity: 95%
1 week
$3,338.00 $2,336.00
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Technical Information
Catalog Number: AA00D85O
Chemical Name: MOTILIN (HUMAN, PORCINE)
CAS Number: 52906-92-0
Molecular Formula: C120H188N34O35S
Molecular Weight: 2699.0485
MDL Number: MFCD00076521
SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CCC(=O)N)CCCCN)CC(=O)N)CCCNC(=N)N)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)N)Cc1ccccc1)Cc1ccc(cc1)O)CCC(=O)O)CC(C)C)CCC(=O)N)CCCNC(=N)N)CCSC)CCC(=O)N)CCC(=O)O
Properties
Complexity: 6010  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 22  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 190  
Hydrogen Bond Acceptor Count: 41  
Hydrogen Bond Donor Count: 39  
Isotope Atom Count: 0  
Rotatable Bond Count: 95  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -14  
Literature fold

Title: The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin.

Journal: British journal of pharmacology20130401

Title: Can small non-peptide motilin agonists force a breakthrough as gastroprokinetic drugs?

Journal: British journal of pharmacology20121001

Title: Acute effects of different glycemic index diets on serum motilin, orexin and neuropeptide Y concentrations in healthy individuals.

Journal: Neuropeptides20120601

Title: Gastrointestinal hormone concentrations associated with gastric feeding in critically ill patients.

Journal: JPEN. Journal of parenteral and enteral nutrition20120301

Title: A new strategy for metabolic stabilization of motilin using the C-terminal part of ghrelin.

Journal: Peptides20120201

Title: Transcription factor binding site polymorphism in the motilin gene associated with left-sided displacement of the abomasum in German Holstein cattle.

Journal: PloS one20120101

Title: Influence of acute exposure to high altitude on basal and postprandial plasma levels of gastroenteropancreatic peptides.

Journal: PloS one20120101

Title: Myenteric neural network activated by motilin in the stomach of Suncus murinus (house musk shrew).

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20111201

Title: [Long-term efficacy and safety research on functional dyspepsia treated with electroacupuncture and Zhizhu Kuanzhong capsule].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion20111201

Title: [Effects of transcutaneous electrical acupoint stimulation combined with general anesthesia on changes of gastric dynamics in controlled hypotension dogs].

Journal: Zhen ci yan jiu = Acupuncture research20111201

Title: Motilin stimulates preadipocyte proliferation and differentiation and adipocyte lipid storage.

Journal: American journal of physiology. Endocrinology and metabolism20111101

Title: The paraventricular nucleus modulates thyroidal motilin release and rat gastric motility.

Journal: Journal of neuroendocrinology20110901

Title: Lactulose in fat-free milk, rather than increased ghrelin and motilin level, might help for solving constipation: author update.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20110601

Title: Simotang enhances gastrointestinal motility, motilin and cholecystokinin expression in chronically stressed mice.

Journal: World journal of gastroenterology20110328

Title: Effect of ginger on gastric motility and symptoms of functional dyspepsia.

Journal: World journal of gastroenterology20110107

Title: Effect of ω-3 fatty acid on gastrointestinal motility after abdominal operation in rats.

Journal: Mediators of inflammation20110101

Title: Comparison of the effects of pantethine and fursultiamine on plasma gastrointestinal peptide levels in healthy volunteers.

Journal: Biological & pharmaceutical bulletin20110101

Title: 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety.

Journal: Bioorganic & medicinal chemistry20101101

Title: Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus).

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20101001

Title: Pharmacologic management of chronic constipation.

Journal: Gastroenterology clinics of North America20100901

Title: Endogenous gastric mediators: patho-physiological role and measurements.

Journal: Current protocols in toxicology20100801

Title: Mechanism of interdigestive migrating motor complex in conscious dogs.

Journal: Journal of gastroenterology20100501

Title: Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats.

Journal: Acta physiologica (Oxford, England)20100501

Title: Colitis affects the smooth muscle and neural response to motilin in the rabbit antrum.

Journal: British journal of pharmacology20100101

Title: Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety.

Journal: Journal of medicinal chemistry20091112

Title: [Promotility drugs use in critical care: indications and limits?].

Journal: Annales francaises d'anesthesie et de reanimation20091101

Title: Emerging drugs for chronic constipation.

Journal: Expert opinion on emerging drugs20090901

Title: An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying.

Journal: European journal of pharmacology20090801

Title: Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats.

Journal: Regulatory peptides20090605

Title: GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20090601

Title: Prokinetic drugs for feed intolerance in critical illness: current and potential therapies.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine20090601

Title: [Clinical observation on transcutaneous electrical acupoint stimulation for treatment of functional dyspepsia].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion20090601

Title: Effect of TZP-201, a novel motilin receptor antagonist, in the colon of the musk shrew (Suncus murinus).

Journal: The Journal of pharmacy and pharmacology20090301

Title: Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.

Journal: Journal of medicinal chemistry20090226

Title: An immunocytochemical study of the endocrine cells in the stomach and duodenum of Zonotrichia capensis subtorquata (Passeriformes, Emberizidae).

Journal: Acta histochemica20090101

Title: Current treatment of nausea and vomiting associated with gastroparesis: antiemetics, prokinetics, tricyclics.

Journal: Gastrointestinal endoscopy clinics of North America20090101

Title: Predictors of gastric myoelectrical activity in type 2 diabetes mellitus.

Journal: Journal of clinical gastroenterology20090101

Title: Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome.

Journal: Expert opinion on investigational drugs20081101

Title: A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis.

Journal: Journal of alternative and complementary medicine (New York, N.Y.)20080901

Title: Effect of ileal infusion of short-chain fatty acids on pancreatic prandial secretion and gastrointestinal hormones in pigs.

Journal: Pancreas20080801

Title: Effect of motilin on the discharge of rat hippocampal neurons responding to gastric distension and its potential mechanism.

Journal: Peptides20080401

Title: Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits.

Journal: European journal of pharmacology20080310

Title: Mutational analysis of predicted intracellular loop domains of human motilin receptor.

Journal: American journal of physiology. Gastrointestinal and liver physiology20080201

Title: Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin.

Journal: General and comparative endocrinology20080101

Title: Effects of motilin and mitemcinal (GM-611) on gastrointestinal contractile activity in rhesus monkeys in vivo and in vitro.

Journal: Digestive diseases and sciences20071101

Title: Emerging drugs for postoperative ileus.

Journal: Expert opinion on emerging drugs20071101

Title: Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits.

Journal: Journal of gastroenterology and hepatology20071001

Title: A comparison study between early enteral nutrition and parenteral nutrition in severe burn patients.

Journal: Burns : journal of the International Society for Burn Injuries20070901

Title: Distribution and electrophysiological effects of motilin in Purkinje cells.

Journal: Neuroreport20070827

Title: [Physiological effects of cold and cool Chinese herbal medicine of channel tropism of stomach on rats with stomach-heat syndrome].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20070601

Title: Effect of acupuncture at Foot-Yangming Meridian on gastric mucosal blood flow, gastric motility and brain-gut peptide.

Journal: World journal of gastroenterology20070421

Title: Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20070401

Title: Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro.

Journal: British journal of pharmacology20070201

Title: Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs.

Journal: Inflammopharmacology20070201

Title: Therapeutic strategies for the management of delayed gastric emptying after pancreatic resection.

Journal: Langenbeck's archives of surgery20070101

Title: Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs.

Journal: Pharmacology20070101

Title: Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs.

Journal: Journal of veterinary pharmacology and therapeutics20061201

Title: [Effects of acute hypobaric hypoxia on gastric emptying and intestinal propulsion: experiment with rats].

Journal: Zhonghua yi xue za zhi20060912

Title: [Clinicopharmacological study of gastrointestinal drugs from the viewpoint of postmarketing development].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20060901

Title: [Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20060901

Title: [Regulative effect of leptin on gastric motility: experiment with conscious rats].

Journal: Zhonghua yi xue za zhi20060829

Title: Intragastric acidification inhibits motilin-induced phase III activity in humans.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20060801

Title: Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy.

Journal: European journal of endocrinology20060701

Title: Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man.

Journal: European journal of clinical investigation20060701

Title: [Effects of intra-amygdaloid injection of motilin on the interdigestive migrating myoelectrical complex in rat].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20060701

Title: Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.

Journal: The Journal of biological chemistry20060505

Title: Clinical application of an enzyme immunoassay for cholecystokinin-like immunoreactive substance for determination of the human plasma levels: the effect of metoclopramide on gastrointestinal peptides and stress-related hormones.

Journal: Journal of peptide science : an official publication of the European Peptide Society20060501

Title: [Effect of motilin on intracellular free calcium of antral smooth muscle cells and its mechanisms].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology20060501

Title: Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways.

Journal: The American journal of gastroenterology20060401

Title: Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus.

Journal: Metabolism: clinical and experimental20060301

Title: Effects of pirenzepine on Dai-kenchu-to-induced elevation of the plasma neuropeptide levels in humans.

Journal: Biological & pharmaceutical bulletin20060101

Title: Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects.

Journal: Pharmacology20060101

Title: A motilin agonist, erythromycin, decreases circulating growth hormone levels in normal subjects but not in diabetic subjects.

Journal: Journal of diabetes and its complications20060101

Title: Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population.

Journal: Neuroscience research20051201

Title: Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon.

Journal: European journal of pharmacology20051107

Title: Small intestinal manometry in patients with systemic sclerosis.

Journal: European journal of gastroenterology & hepatology20051101

Title: Preproghrelin Leu72Met polymorphism in obese Korean children.

Journal: Journal of pediatric endocrinology & metabolism : JPEM20051101

Title: Basic and clinical pharmacology of new motility promoting agents.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20051001

Title: [Effects of acupuncture on the gastric motivity in patients with functional dyspepsia].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine20051001

Title: Regulation of vascular reactivity by established and emerging GPCRs.

Journal: Trends in pharmacological sciences20050901

Title: Effects of domperidone on human plasma levels of motilin, somatostatin, gastrin, adrenocorticotropic hormone and cortisol.

Journal: Biological & pharmaceutical bulletin20050901

Title: [Distribution and role of motilin receptor in the amygdala of rats].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA20050901

Title: Effect of erythromycin on gastric dysmotility and neuroendocrine peptides in rats with diabetes mellitus.

Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih20050901

Title: [Effects of intrahippocampal microinjection of motilin on interdigestive migrating myoelectrical complexes of rat duodenum].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA20050801

Title: Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog.

Journal: The Journal of pharmacology and experimental therapeutics20050601

Title: Ecabet sodium raises plasma levels of calcitonin generelated peptide and substance P in healthy humans.

Journal: The Journal of pharmacy and pharmacology20050601

Title: [Measurements and significance of serum gastrin, plasma motilin and serum beta-endorphin in patients with severe burns].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery]20050601

Title: Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.

Journal: European journal of pharmacology20050516

Title: Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes.

Journal: Clinical biochemistry20050501

Title: Excitatory actions of motilin on myenteric neurons of the guinea-pig small intestine.

Journal: Autonomic neuroscience : basic & clinical20050331

Title: Omeprazole raises somatostatin and motilin in human plasma.

Journal: Biological & pharmaceutical bulletin20050201

Title: Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus.

Journal: Regulatory peptides20050115

Title: Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors.

Journal: American journal of physiology. Gastrointestinal and liver physiology20050101

Title: Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]20050101

Title: Effect of environmental hyperthermia on gastrin, somatostatin and motilin in rat ulcerated antral mucosa.

Journal: World journal of gastroenterology20041201

Title: Effects of motilin and ursodeoxycholic acid on gastrointestinal myoelectric activity of different origins in fasted rats.

Journal: World journal of gastroenterology20040901

Title: Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis.

Journal: Alimentary pharmacology & therapeutics20040801

Title: Relationship between intraduodenal 5-hydroxytryptamine release and interdigestive contractions in dogs.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi20040601

Title: Discovery of a potent and novel motilin agonist.

Journal: Journal of medicinal chemistry20040325

Title: Neuromodulation of experimental Shigella infection reduces damage to the gut mucosa.

Journal: Microbes and infection20040301

Title: Screening of a large panel of gastrointestinal peptide plasma levels is not adapted for the evaluation of digestive damage following irradiation.

Journal: Canadian journal of physiology and pharmacology20040201

Title: Autonomic neuropathy and gastrointestinal motility disorders in children and adolescents with type 1 diabetes mellitus.

Journal: Journal of pediatric gastroenterology and nutrition20040101

Title: Quantitative determination of the polypeptide motilin in rat plasma by externally calibrated liquid chromatography/electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20040101

Title: [Clinical observation on treatment of gastro-esophageal reflux with modified zhizhu pill].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine20040101

Title: Effect of motilin on endogenous release of insulin in conscious dogs in the fed state.

Journal: Digestive diseases and sciences20031201

Title: Excitatory effects of motilin in the hippocampus on gastric motility in rats.

Journal: Brain research20030912

Title: Gastrointestinal motility disorders and gastrointestinal prokinetic therapy.

Journal: The Veterinary clinics of North America. Small animal practice20030901

Title: [Effect of motilin on gastric smooth contraction induced by interstitial cells of Cajal].

Journal: Zhonghua yi xue za zhi20030825

Title: Intestinal aspects of cholesterol gallstone formation.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver20030701

Title: Motilin-bicelle interactions: membrane position and translational diffusion.

Journal: FEBS letters20030619

Title: Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20030401

Title: [Synthetic studies of microbial natural products from microorganisms].

Journal: The Japanese journal of antibiotics20030201

Title: The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?

Journal: Regulatory peptides20021231

Title: Motilin regulates interdigestive gastric blood flow in dogs.

Journal: Gastroenterology20021101

Title: (13)C-(1)H NMR relaxation and fluorescence anisotropy decay study of tyrosine dynamics in motilin.

Journal: Biophysical journal20021101

Title: Atropine-induced gastric dysrhythmia is not normalized by electroacupuncture.

Journal: Digestive diseases and sciences20021101

Title: The structure of erythromycin enol ether as a model for its activity as a motilide.

Journal: Journal of medicinal chemistry20021024

Title: Intraduodenal capsaicin inhibits gastric migrating motor complex via an extrinsic neural reflex in conscious dogs.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20021001

Title: A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.

Journal: The Journal of clinical endocrinology and metabolism20020801

Title: [Effect of jianpi wenshen decoction on serum gastrin, plasma motilin and somatostatin in patients of diabetic diarrhea].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine20020801

Title: [The other gastrointestinal hormones in diabetes mellitus].

Journal: Nihon rinsho. Japanese journal of clinical medicine20020701

Title: Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats.

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA20020701

Title: Design and synthesis of novel tetra-peptide motilin agonists.

Journal: Bioorganic & medicinal chemistry20020601

Title: In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20020601

Title: The motilin pharmacophore in CHO cells expressing the human motilin receptor.

Journal: Biochemical and biophysical research communications20020517

Title: Effects of motilin on human interdigestive gastrointestinal and gallbladder motility, and involvement of 5HT3 receptors.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20020401

Title: Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. Critical role of second extracellular loop for peptide binding and action.

Journal: The Journal of biological chemistry20020322

Title: Potentiation of motilin-induced contraction by nitric oxide synthase inhibition in the isolated chicken gastrointestinal tract.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20020201

Title: Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin.

Journal: Journal of medicinal chemistry20020131

Title: Effect of erythromycin on gastroduodenal contractile activity in developing neonates.

Journal: Journal of pediatric gastroenterology and nutrition20020101

Title: Effects of adjustable gastric banding on altered gut neuropeptide levels in morbidly obese patients.

Journal: Obesity surgery20011201

Title: Pressure-geometry relationship in the antroduodenal region in humans.

Journal: American journal of physiology. Gastrointestinal and liver physiology20011101

Title: Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.

Journal: The Journal of biological chemistry20010921

Title: Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial.

Journal: Gut20010901

Title: Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin.

Journal: Biological & pharmaceutical bulletin20010901

Title: Gastric myoelectrical activity and gut hormone secretion in myotonic dystrophy.

Journal: European journal of gastroenterology & hepatology20010701

Title: The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

Journal: European journal of pharmacology20010629

Title: Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs.

Journal: Digestive diseases and sciences20010601

Title: Interdigestive gallbladder emptying, antroduodenal motility, and motilin release patterns are altered in cholesterol gallstone patients.

Journal: Digestive diseases and sciences20010601

Title: Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.

Journal: Brain research20010323

Title: Effect of duodenectomy on gastric motility and gastric hormones in dogs.

Journal: Annals of surgery20010301

Title: Contractile effects and intracellular Ca2+ signalling induced by motilin and erythromycin in the circular smooth muscle of human colon.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20010201

Title: Immunohistochemical study of the distribution of endocrine cells in the gastrointestinal tract of the camel (Camelus bactrianus).

Journal: European journal of morphology20010201

Title: Growth hormone secretagogue receptor family members and ligands.

Journal: Endocrine20010201

Title: Design and synthesis of N-terminal cyclic motilin partial peptides: a novel pure motilin antagonist.

Journal: Chemical & pharmaceutical bulletin20010101

Title: Effects of intraduodenal bile on interdigestive gastrointestinal and gallbladder motility in healthy subjects.

Journal: Digestion20010101

Title: Discovery of the first non-peptide antagonist of the motilin receptor.

Journal: Drug design and discovery20010101

Title: Gastroprokinetic effect and mechanism of SK-896, a new motilin analogue, during the interdigestive period in conscious dogs.

Journal: Pharmacology20010101

Title: Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: a pilot study.

Journal: Digestion20010101

Title: Motilin and motilin receptors: characterization and functional significance.

Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie20010101

Title: An unusual metastatic motilin-secreting neuroendocrine tumour with a 20-year survival. Pathological, biochemical and motility features.

Journal: Digestion20010101

Title: Receptor for motilin identified in the human gastrointestinal system.

Journal: Science (New York, N.Y.)19990625

Title: Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum.

Journal: Clinical and experimental pharmacology & physiology19990301

Title: GM-109: a novel, selective motilin receptor antagonist in the smooth muscle of the rabbit small intestine.

Journal: The Journal of pharmacology and experimental therapeutics19950501

Title: Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones.

Journal: Life sciences19940101

Title: Coulie B, et al. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J Biol Chem. 2001 Sep 21;276(38):35518-22. Epub 2001 Jul 18.

Title: Huang J, et al. Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G23-31.

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