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137339-65-2,MFCD00133815
Catalog No.:AA009ATO

137339-65-2 | SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-LYS-TYR-GLU-PRO-PHE

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1mg
98%
1 week  
$162.00   $113.00
- +
5mg
98%
1 week  
$495.00   $347.00
- +
10mg
98%
1 week  
$828.00   $580.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009ATO
Chemical Name:
SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-LYS-TYR-GLU-PRO-PHE
CAS Number:
137339-65-2
Molecular Formula:
C81H118N20O23
Molecular Weight:
1739.9238
MDL Number:
MFCD00133815
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)CCC(=O)O)Cc1ccc(cc1)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)Cc1ccccc1)CC(C)C)CC(C)C)CCCNC(=N)N)CC(=O)N)CC(=O)N)CC(=O)O
Properties
Computed Properties
 
Complexity:
3670  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
14  
Heavy Atom Count:
124  
Hydrogen Bond Acceptor Count:
26  
Hydrogen Bond Donor Count:
23  
Rotatable Bond Count:
54  
XLogP3:
-7.4  

Literature

Title: Parthenolide inhibits TRIF-dependent signaling pathway of Toll-like receptors in RAW264.7 macrophages.

Journal: Molecules and cells 20110331

Title: A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

Journal: Blood 20060115

Title: The inhibitory potency of clopidogrel on ADP-induced platelet activation is not attenuated when it is co-administered with atorvastatin (20 mg/day) for 5 weeks in patients with acute coronary syndromes.

Journal: Platelets 20050801

Title: Antithrombin reduces compression-induced spinal cord injury in rats.

Journal: Journal of neurotrauma 20041201

Title: Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes.

Journal: Circulation 20040323

Title: The agonist of the protease-activated receptor-1 (PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cells.

Journal: Cellular and molecular life sciences : CMLS 20030801

Title: Thrombin-stimulated Pyk2 phosphorylation in human endothelium is dependent on intracellular calcium and independent of protein kinase C and Src kinases.

Journal: Biochemical and biophysical research communications 20020628

Title: Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

Journal: Bioorganic & medicinal chemistry letters 20020211

Title: Potentiation of ibudilast inhibition of platelet aggregation in the presence of endothelial cells.

Journal: Thrombosis research 20010501

Title: Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells.

Journal: The Journal of pharmacy and pharmacology 19970801

Title: Stimulation of the thrombin receptor of human glomerular mesangial cells by Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe peptide.

Journal: The Journal of biological chemistry 19921005

Title: Sugama Y, et al. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism. Circ Res. 1992 Oct;71(4):1015-9.

Title: Sabo T, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10.

Title: Maruyama Y, et al. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9.

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SDS
Tags:137339-65-2 Molecular Formula|137339-65-2 MDL|137339-65-2 SMILES|137339-65-2 SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-LYS-TYR-GLU-PRO-PHE