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5534-95-2,MFCD00076515
Catalog No.:AA00D9ZJ

5534-95-2 | PENTAGASTRIN

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10mg
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25mg
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$206.00   $144.00
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50mg
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100mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00D9ZJ
Chemical Name:
PENTAGASTRIN
CAS Number:
5534-95-2
Molecular Formula:
C37H49N7O9S
Molecular Weight:
767.8915
MDL Number:
MFCD00076515
SMILES:
CSCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)CCNC(=O)OC(C)(C)C
Properties
Computed Properties
 
Complexity:
1310  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
54  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
22  
XLogP3:
1.5  

Downstream Synthesis Route

[1]Henklein;Boomgaarden;Nieke;Georgi;Niedrich[Pharmazie,1988,vol.43,#1,p.10-11]

[1]Hammadi,Akli;Meunier,Gilles;Menez,Andre;Genet,Roger[TetrahedronLetters,1998,vol.39,#19,p.2955-2958]

[2]Hammadi,Akli;Lam,Hubert;Gondry,Muriel;Ménez,André;Genet,Roger[Tetrahedron,2000,vol.56,#26,p.4473-4477]

207744-21-6    5534-95-2   
Boc-βAla-(R)Trp-Met-Asp-Phe-NH2 

[1]Hammadi,Akli;Lam,Hubert;Gondry,Muriel;Ménez,André;Genet,Roger[Tetrahedron,2000,vol.56,#26,p.4473-4477]

5534-95-2   
Boc-βAla-2',3'-2H2-Trp-Met-Asp-Phe-NH2 

[1]Hammadi,Akli;Meunier,Gilles;Menez,Andre;Genet,Roger[TetrahedronLetters,1998,vol.39,#19,p.2955-2958]

5534-95-2   
Boc-βAla-2',3'-2H2-(R)Trp-Met-Asp-Phe-NH2 

[1]Hammadi,Akli;Meunier,Gilles;Menez,Andre;Genet,Roger[TetrahedronLetters,1998,vol.39,#19,p.2955-2958]

Literature

Title: The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat.

Journal: British journal of pharmacology 20120701

Title: Morphological evidence that pentagastrin regulates secretion in the human parotid gland.

Journal: Journal of anatomy 20120501

Title: CCK receptors-related signaling involved in nitric oxide production caused by gastrin 17 in porcine coronary endothelial cells.

Journal: Molecular and cellular endocrinology 20120305

Title: Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell.

Journal: Pflugers Archiv : European journal of physiology 20120301

Title: Comparison of calcium and pentagastrin tests for the diagnosis and follow-up of medullary thyroid cancer.

Journal: The Journal of clinical endocrinology and metabolism 20120301

Title: Influence of gastric acid on gastric emptying and gastric distension-induced pain response in rats--effects of famotidine and mosapride.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120201

Title: Calcium [¹³C]carbonate breath test for quantitative measurement of total gastric acid in rats.

Journal: Scandinavian journal of gastroenterology 20120201

Title: Can injection of pentagastrin stimulate the identification of metastases of medullary thyroid carcinoma by (18)F-FDG PET/CT?

Journal: Hellenic journal of nuclear medicine 20120101

Title: Using absorption simulation and gastric pH modulated dog model for formulation development to overcome achlorhydria effect.

Journal: Molecular pharmaceutics 20111205

Title: Combination therapy for managing difficult-to-treat patients with stage 2 hypertension: focus on valsartan-based combinations.

Journal: American journal of therapeutics 20111101

Title: Screening for medullary thyroid carcinoma with serum calcitonin measurements in patients with thyroid nodules in the United States and Canada.

Journal: Thyroid : official journal of the American Thyroid Association 20111101

Title: Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds.

Journal: Journal of pharmaceutical sciences 20110701

Title: Basal and stimulated calcitonin and procalcitonin by various assays in patients with and without medullary thyroid cancer.

Journal: Clinical chemistry 20110301

Title: Disruption of opioid-induced placebo responses by activation of cholecystokinin type-2 receptors.

Journal: Psychopharmacology 20110201

Title: Pentagastrin-induced hemoconcentration in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol.

Journal: Journal of psychopharmacology (Oxford, England) 20110101

Title: Relationship between respiratory, endocrine, and cognitive-emotional factors in response to a pharmacological panicogen.

Journal: Depression and anxiety 20101101

Title: A meal test improves the specificity of chromogranin A as a marker of neuroendocrine neoplasia.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20101001

Title: Differentiation between thyroidal and ectopic calcitonin secretion in patients with coincidental thyroid nodules and pancreatic tumors - a report of two cases.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20100801

Title: New mutations in the RET protooncogene-L881V - associated with medullary thyroid carcinoma and -R770Q - in a patient with mixed medullar/follicular thyroid tumour.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20100801

Title: Predictive value of pentagastrin test for preoperative differential diagnosis between C-cell hyperplasia and medullary thyroid carcinoma in patients with moderately elevated basal calcitonin levels.

Journal: Clinical endocrinology 20100701

Title: Calcitonin screening and pentagastrin testing: predictive value for the diagnosis of medullary carcinoma in nodular thyroid disease.

Journal: European journal of endocrinology 20100601

Title: Modification of gastric pH in the fasted dog.

Journal: The Journal of pharmacy and pharmacology 20100401

Title: Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.

Journal: Pancreas 20100301

Title: Functional and histologic assessment of rat gastric mucosa after chronic treatment with sulphurous thermal water.

Journal: Pharmacology 20100101

Title: Traffic noise exposure increases gastric acid secretion in rat.

Journal: Acta medica Iranica 20100101

Title: Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer.

Journal: Endocrine-related cancer 20091201

Title: Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors.

Journal: The Chinese journal of physiology 20091130

Title: Potency and tolerance of calcitonin stimulation with high-dose calcium versus pentagastrin in normal adults.

Journal: The Journal of clinical endocrinology and metabolism 20090801

Title: The effect of gastric secretion on gastric physiology and emptying in the fasted and fed state assessed by magnetic resonance imaging.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090701

Title: Effect of free dietary glutamate on gastric secretion in dogs.

Journal: Annals of the New York Academy of Sciences 20090701

Title: Sporadic hypercalcitoninemia: clinical and therapeutic consequences.

Journal: Endocrine-related cancer 20090301

Title: Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

Title: Gastric secretions affected by esophageal distention in the rat.

Journal: Journal of gastroenterology 20090101

Title: Bravo capsule system optimizes intragastric pH monitoring over prolonged time: effects of ghrelin on gastric acid and hormone secretion in the rat.

Journal: World journal of gastroenterology 20081028

Title: Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activation.

Journal: Biological psychiatry 20081015

Title: [Can measurement of basal calcitonin replace the pentagastrin test?].

Journal: Ugeskrift for laeger 20081006

Title: Peripheral dopamine D2-like receptors have a regulatory effect on carbachol-, histamine- and pentagastrin-stimulated gastric acid secretion.

Journal: Clinical and experimental pharmacology & physiology 20080901

Title: Inhibition of H+/K+ ATPase in the gastroprotective effect of Baccharis illinita DC.

Journal: The Journal of pharmacy and pharmacology 20080801

Title: Validation of a conscious rat model for the discovery of novel agents that inhibit gastric acid secretion.

Journal: European journal of pharmacology 20080728

Title: Medullary thyroid cancer responsiveness to pentagastrin stimulation: an early surrogate parameter of tumor dissemination?

Journal: The Journal of clinical endocrinology and metabolism 20080601

Title: Emotional perception modulated by an opioid and a cholecystokinin agonist.

Journal: Psychopharmacology 20080401

Title: Effect of time of preparation on pentagastrin-induced symptom, endocrine and cardiovascular responses.

Journal: Psychiatry research 20080315

Title: Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction.

Journal: Endocrine-related cancer 20080301

Title: Synthesis of a novel pentagastrin-drug conjugate for a targeted tumor therapy.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

Title: Symptomatic response to blocked and unblocked pentagastrin stimulation in functional dyspepsia. Comparison of responders and non-responders to omeprazole identified in a single-subject trial model.

Journal: Digestive diseases (Basel, Switzerland) 20080101

Title: Medullary thyroid microcarcinoma recommendations for treatment - a single-center experience.

Journal: Surgery 20071201

Title: Marjoram increases basal gastric acid and pepsin secretions in rat.

Journal: Phytotherapy research : PTR 20071101

Title: [Mutation of the RET proto-oncogene in type 2A multiple endocrine neoplasia Chinese families and the application of pentagastrin stimulation test in diagnosis and follow-up].

Journal: Zhonghua nei ke za zhi 20071101

Title: Delayed increase in LDL cholesterol following pentagastrin-induced panic attacks.

Journal: Psychopharmacology 20070801

Title: Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion.

Journal: Journal of medicinal chemistry 20070628

Title: Secretion of total pepsin and pepsin 1 in healthy volunteers in response to pentagastrin and to insulin-induced hypoglycaemia.

Journal: Scandinavian journal of gastroenterology 20070501

Title: Identification of occult metastases of medullary thyroid carcinoma by pentagastrin-stimulated intravenous calcitonin sampling followed by targeted surgery.

Journal: Clinical endocrinology 20070301

Title: Development and validation of a preclinical food effect model.

Journal: Journal of pharmaceutical sciences 20070201

Title: Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules.

Journal: The Journal of clinical endocrinology and metabolism 20070201

Title: The value of intraoperative pentagastrin testing in medullary thyroid cancer.

Journal: Surgery 20070201

Title: Neuronal excitability in the periaqueductal grey matter during the estrous cycle in female Wistar rats.

Journal: Neuroscience 20070105

Title: HPA axis activity in patients with panic disorder: review and synthesis of four studies.

Journal: Depression and anxiety 20070101

Title: Calcitonin concentrations in patients with chronic kidney disease and medullary thyroid carcinoma or c-cell hyperplasia.

Journal: Kidney international 20061201

Title: Pentagastrin-induced nitric oxide-dependent protein secretion from the parotid gland of the anaesthetized rat.

Journal: Experimental physiology 20061101

Title: Long-term effects of elevated gastrin levels on calcitonin secretion.

Journal: Journal of endocrinological investigation 20061001

Title: Review article: human pepsins - their multiplicity, function and role in reflux disease.

Journal: Alimentary pharmacology & therapeutics 20060901

Title: Pentagastrin-induced protein synthesis in the parotid gland of the anaesthetized rat, and its dependence on CCK-A and -B receptors and nitric oxide generation.

Journal: Experimental physiology 20060701

Title: Cardiovascular and respiratory responses to a panicogenic agent in anaesthetised female Wistar rats at different stages of the oestrous cycle.

Journal: The European journal of neuroscience 20060601

Title: Cholecystokinin- and gastrin-induced protein and amylase secretion from the parotid gland of the anaesthetized rat.

Journal: Regulatory peptides 20060515

Title: Effect of somatostatin analogue octreotide injected into the third cerebral ventricle on pentagastrin-induced gastric acid secretion in rats.

Journal: World journal of gastroenterology 20060507

Title: Formulation of solid dosage forms to overcome gastric pH interaction of the factor Xa inhibitor, BMS-561389.

Journal: Pharmaceutical research 20060501

Title: Value of routine measurement of serum calcitonin concentrations in patients with nodular thyroid disease: A multicenter study.

Journal: Journal of endocrinological investigation 20060501

Title: [Sporadic C-cell hyperplasia associated with multinodular goiter].

Journal: Pathologica 20060401

Title: Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.

Journal: World journal of gastroenterology 20060328

Title: Effects of cyclooxygenase-1 and -2 inhibition on gastric acid secretion and cardiovascular functions in rats.

Journal: Pharmacology 20060101

Title: Inhibition of pentagastrin-stimulated gastric acid secretion by pantoprazole and omeprazole in healthy adults.

Journal: Digestive diseases and sciences 20060101

Title: [Leu-enkephalin modulates gastric secretion activated by various stimulants].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20060101

Title: [The role of short chain fatty acids and lactate in regulation of the gastric secretion].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20060101

Title: [Useful and limits of the biochemical markers for the diagnosis of thyroid carcinoma].

Journal: Annali italiani di chirurgia 20060101

Title: Effect of aqueous extract of neem (Azadirachta indica) leaves on offensive and diffensive gastric mucosal factors in rats.

Journal: Indian journal of physiology and pharmacology 20060101

Title: Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma.

Journal: Clinical endocrinology 20051201

Title: Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.

Journal: Journal of medicinal chemistry 20051103

Title: Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat.

Journal: Regulatory peptides 20051101

Title: The effect of intragastric ammonia production on titratable gastric acid output in Helicobacter pylori-infected patients with chronic gastritis.

Journal: Digestive diseases and sciences 20051101

Title: Early diagnosis and curative therapy of medullary thyroid carcinoma by routine measurement of serum calcitonin in patients with thyroid disorders.

Journal: Thyroid : official journal of the American Thyroid Association 20051101

Title: Primary hyperparathyroidism as the leading symptom in a patient with a Y791F RET mutation.

Journal: Thyroid : official journal of the American Thyroid Association 20051101

Title: Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro.

Journal: European journal of pharmacology 20051003

Title: Ghrelin in human medullary thyroid carcinomas.

Journal: Clinical endocrinology 20051001

Title: Necessity of intracellular cyclic AMP in inducing gastric acid secretion via muscarinic M3 and cholecystokinin2 receptors on parietal cells in isolated mouse stomach.

Journal: Life sciences 20050902

Title: Reversibility of 'secondary hypercalcitoninemia' after kidney transplantation.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050701

Title: Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050701

Title: Cognitive modulation of the endocrine stress response to a pharmacological challenge in normal and panic disorder subjects.

Journal: Archives of general psychiatry 20050601

Title: Increased calcitonin level in thyroid nodules without medullary carcinoma.

Journal: The British journal of surgery 20050501

Title: The relationship between a pentagastrin-stimulated gastric luminal acid production test (Gastrotest) and enteral feeding-related gastrointestinal complications in critically ill patients.

Journal: Anesthesia and analgesia 20050501

Title: TGF-beta3 inhibits pentagastrin-stimulated gastric acid secretion in rats.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20050301

Title: [Concentration of hydrochloric acid and pepsin in gastric juice in dogs after starvation and refeeding].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20050301

Title: Rebound acid hypersecretion after long-term inhibition of gastric acid secretion.

Journal: Alimentary pharmacology & therapeutics 20050115

Title: Acute effect of gamma irradiation on gastric acid secretion and gastric mucosal integrity in the rat.

Journal: TheScientificWorldJournal 20050101

Title: Pentagastrin-induced gastric acid secretion in the diabetic rats: role of insulin.

Journal: The Chinese journal of physiology 20041231

Title: Gastric antisecretory effects of synthetic cannabinoids after central or peripheral administration in the rat.

Journal: Brain research bulletin 20041215

Title: Effects of propranolol on symptom and endocrine responses to pentagastrin.

Journal: Psychoneuroendocrinology 20041001

Title: Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands.

Journal: Gut 20040801

Title: Total enzymatic synthesis of cholecystokinin CCK-5.

Journal: Amino acids 20040801

Title: Frequency of RET proto-oncogene mutations in patients with normal and with moderately elevated pentagastrin-stimulated serum concentrations of calcitonin.

Journal: Thyroid : official journal of the American Thyroid Association 20040801

Title: Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice.

Journal: Peptides 20040801

Title: Reduction of SNAP25 in acid secretion defect of Foxl1-/- gastric parietal cells.

Journal: Biochemical and biophysical research communications 20040730

Title: Peripheral GABAB agonists stimulate gastric acid secretion in mice.

Journal: British journal of pharmacology 20040701

Title: Effect of repeat exposure on neuroendocrine and symptom responses to pentagastrin.

Journal: Psychiatry research 20040530

Title: Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expression.

Journal: Annals of surgery 20040401

Title: Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040301

Title: Cholecystokinin (CCK) stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascade.

Journal: The Journal of clinical endocrinology and metabolism 20040301

Title: Neuronal histamine H(3) receptors mediate antisecretory effects in the rat isolated gastric fundus.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040301

Title: Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

Title: Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency.

Journal: Blood 20040215

Title: Frequency and relevance of elevated calcitonin levels in patients with neoplastic and nonneoplastic thyroid disease and in healthy subjects.

Journal: The Journal of clinical endocrinology and metabolism 20040201

Title: Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040101

Title: Effect of dietary corn oil supplementation on equine gastric fluid acid, sodium, and prostaglandin E2 content before and during pentagastrin infusion.

Journal: Journal of veterinary internal medicine 20040101

Title: Secretory function of the esophageal mucosa in opossum: the role of cholinergic, peptidergic and histaminergic pathways.

Journal: Roczniki Akademii Medycznej w Bialymstoku (1995) 20040101

Title: When should thyroidectomy be performed in familial medullary thyroid carcinoma gene carriers with non-cysteine RET mutations?

Journal: Surgery 20031201

Title: Gastric analysis with fractional test meals (ethanol, caffeine, and peptone meal), augmented histamine or pentagastrin tests, and gastric pH recording.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20031201

Title: Mild persistent hypercalcitoninemia after total thyroidectomy in patients with papillary thyroid carcinoma.

Journal: Endocrine journal 20030801

Title: Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via CRH system.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030601

Title: G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors.

Journal: Assay and drug development technologies 20030601

Title: Effects of thyroid hormones on basal and stimulated gastric acid secretion due to histamine, carbachol and pentagastrin in rats.

Journal: Saudi medical journal 20030401

Title: The potential of ordered mesoporous silica for the storage of drugs: the example of a pentapeptide encapsulated in a MSU-tween 80.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20030317

Title: Pentagastrin test for anxiety--psychophysiology and personality.

Journal: Psychopharmacology 20030301

Title: Endogenous CCK depresses contractile activity within the ascending myenteric reflex pathway of rat ileum.

Journal: Neuropharmacology 20030301

Title: Pentagastrin-induced release of free fatty acids in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol.

Journal: Journal of psychiatry & neuroscience : JPN 20030301

Title: Hypothalamic-pituitary adrenal response to cholecystokinin-B receptor agonism is resistant to cortisol feedback inhibition.

Journal: Psychoneuroendocrinology 20030201

Title: Gastric hypersecretion associated to iodoacetamide-induced mild gastritis in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030201

Title: Abnormal pentagastrin response in a patient with pseudohypoparathyroidism.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030201

Title: Review article: pharmacology of esomeprazole and comparisons with omeprazole.

Journal: Alimentary pharmacology & therapeutics 20030201

Title: Expanded parietal cell pool in transgenic mice unable to synthesize histamine.

Journal: Scandinavian journal of gastroenterology 20030201

Title: Panic-related responses to pentagastrin, flumazenil, and thyrotropin-releasing hormone in healthy volunteers.

Journal: Depression and anxiety 20030101

Title: Demonstration of acid secretion in the gastric pouch through the pentagastrin stimulation test.

Journal: Urologia internationalis 20030101

Title: Potential absence of prognostic implications of severe preoperative hypercalcitoninemia in medullary thyroid carcinoma.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20030101

Title: Dynamic investigation for evaluation of calcium metabolism and parathyroid function.

Journal: Journal of endocrinological investigation 20030101

Title: A defined human gastrin sequence stimulates the growth of Helicobacter pylori.

Journal: FEMS microbiology letters 20021217

Title: Pentagastrin-induced sleep panic attacks: panic in the absence of elevated baseline arousal.

Journal: Biological psychiatry 20021215

Title: Coordinated regulation of gastric chloride secretion with both acid and alkali secretion.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20021101

Title: Acid-inhibitory potency of ranitidine in diabetic rats.

Journal: Pharmacology 20020901

Title: Comparison of two provocative tests for calcitonin in medullary thyroid carcinoma: omeprazole vs pentagastrin.

Journal: Clinical chemistry 20020901

Title: Can sporadic medullary thyroid carcinoma be biochemically predicted? Prospective analysis of 66 operated patients with elevated serum calcitonin levels.

Journal: World journal of surgery 20020801

Title: rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest.

Journal: Biological psychiatry 20020715

Title: Different role of the histamine H3-receptor in vagal-, betanechol-, pentagastrin-induced gastric acid secretion in anaesthetized rats.

Journal: Scandinavian journal of gastroenterology 20020701

Title: Anxiogenic effects of the CCK(B) agonist pentagastrin in humans and dose-dependent increase in plasma C-peptide levels.

Journal: Psychopharmacology 20020601

Title: Neuroactive steroid changes in response to challenge with the panicogenic agent pentagastrin.

Journal: Psychoneuroendocrinology 20020501

Title: Proton pump activation in stimulated parietal cells is regulated by gastric acid secretory capacity: a human study.

Journal: Journal of clinical pharmacology 20020501

Title: Pharmacological characterization of cholecystokinin receptors mediating contraction of human gallbladder and ascending colon.

Journal: Regulatory peptides 20020415

Title: Recommendations for reporting C cell pathology of the thyroid.

Journal: Wiener klinische Wochenschrift 20020415

Title: Putative effect of Helicobacter pylori and gastritis on gastric acid secretion in cat.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020401

Title: Abnormal pentagastrin response in a patient with pseudohypoparathyroidism.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20020401

Title: Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach.

Journal: British journal of pharmacology 20020401

Title: Proliferation of intestinal crypt cells by gastrin-induced ornithine decarboxylase.

Journal: World journal of gastroenterology 20020215

Title: The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020201

Title: Vagal stimulation rapidly increases leptin secretion in human stomach.

Journal: Gastroenterology 20020201

Title: Helicobacter pylori, parietal cell antibodies and autoimmune gastropathy in type 1 diabetes mellitus.

Journal: Alimentary pharmacology & therapeutics 20020201

Title: Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.

Journal: Cancer 20020115

Title: Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma.

Journal: European journal of endocrinology 20020101

Title: Pharmacologic interventions in nuclear radiology: indications, imaging protocols, and clinical results.

Journal: Radiographics : a review publication of the Radiological Society of North America, Inc 20020101

Title: Gastrimmune-induced antigastrin-17 antibodies inhibit acid secretion in a rat fistula model.

Journal: Alimentary pharmacology & therapeutics 20011201

Title: Microinjection of bombesin into the ventrolateral reticular formation inhibits peripherally stimulated gastric acid secretion through spinal pathways in rats.

Journal: Brain research 20011109

Title: Intragastric pH regulates conversion from net acid to net alkaline secretion by the rat stomach.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20011001

Title: Pharmacokinetics and pharmacodynamics of esomeprazole, the S-isomer of omeprazole.

Journal: Alimentary pharmacology & therapeutics 20011001

Title: Effect of ethinyl estradiol on the panic response to the panicogenic agent pentagastrin.

Journal: Journal of affective disorders 20011001

Title: Excitatory stimulation of neurons in the arcuate nucleus inhibits gastric acid secretion via vagal pathways in anesthetized rats.

Journal: Brain research 20010914

Title: Familial medullary thyroid carcinoma with noncysteine ret mutations: phenotype-genotype relationship in a large series of patients.

Journal: The Journal of clinical endocrinology and metabolism 20010801

Title: Pseudohypoparathyroidism Ia and hypercalcitoninemia.

Journal: The Journal of clinical endocrinology and metabolism 20010701

Title: Response to pentagastrin after acute phenylalanine and tyrosine depletion in healthy men: a pilot study.

Journal: Journal of psychiatry & neuroscience : JPN 20010501

Title: False serum calcitonin high levels using a non-competitive two-site IRMA.

Journal: Journal of endocrinological investigation 20010501

Title: Effect of medroxyprogesterone pretreatment on pentagastrin-induced panic symptoms in females with panic disorder.

Journal: Psychiatry research 20010415

Title: Nonpeptide cholecystokinin-2 receptor agonists.

Journal: Journal of medicinal chemistry 20010412

Title: Mucosal protective effects of ecabet sodium: pepsin inhibition and interaction with mucus.

Journal: Clinical science (London, England : 1979) 20010401

Title: Does gastric juice pH influence tonometric PCO2 measured by automated air tonometry?

Journal: American journal of respiratory and critical care medicine 20010401

Title: The quest for biological correlates of social phobia: an interim assessment.

Journal: Acta psychiatrica Scandinavica 20010401

Title: Abolition of pentagastrin-stimulated alkaline tide using the carbonic anhydrase inhibitor acetazolamide.

Journal: The Israel Medical Association journal : IMAJ 20010401

Title: Impaired pancreatic secretion in severely malnourished patients is a consequence of primary pancreatic dysfunction.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20010301

Title: [Effects of calcium channel antagonist on gastrin-induced proliferation of HT29 colon carcinoma cells].

Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010301

Title: Dose response of arginine vasopressin to the CCK-B agonist pentagastrin.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010201

Title: Intraluminal acid and gastric mucosal integrity: the importance of blood-borne bicarbonate.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010101

Title: Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers.

Journal: Alimentary pharmacology & therapeutics 20010101

Title: Gastric acid secretory response in Helicobacter pylori-positive patients with duodenal ulcer disease.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20010101

Title: Pheochromocytoma in multiple endocrine neoplasia type 2: a prospective study.

Journal: European journal of endocrinology 20010101

Title: Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo.

Journal: Arzneimittel-Forschung 20010101

Title: Effects of short term treatment with pentagastrin, proglumide, tamoxifen given separately or together with 5-fluorouracil on the growth in the murine transplantable Colon 38 cancer.

Journal: Neoplasma 20010101

Title: Effect of pentagastrin on steroid secretion and proliferative activity of regenerating rat adrenal cortex.

Journal: Cytobios 20010101

Title: [Acid producing function of the stomach in patients with duodenal ulcer and diabetes mellitus].

Journal: Klinicheskaia meditsina 20010101

Title: Phytohaemagglutinin inhibits gastric acid but not pepsin secretion in conscious rats.

Journal: Journal of physiology, Paris 20010101

Title: Cholecystokinin and panic disorder: past and future clinical research strategies.

Journal: Scandinavian journal of clinical and laboratory investigation. Supplementum 20010101

Title: Dose response of adrenocorticotropin and cortisol to the CCK-B agonist pentagastrin.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19991001

Title: Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist.

Journal: European journal of pharmacology 19990312

Title: Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex.

Journal: British journal of pharmacology 19990301

Title: A comparison of the effects of intravenous pentagastrin on patients with social phobia, panic disorder and healthy controls.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19970301

Title: YF476 is a new potent and selective gastrin/cholecystokinin-B receptor antagonist in vitro and in vivo.

Journal: Alimentary pharmacology & therapeutics 19970201

Title: (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.

Journal: Journal of medicinal chemistry 19970131

Title: Effect of adenosine and histamine receptor stimulation on canine histamine release to pentagastrin.

Journal: Digestion 19970101

Title: Secretin inhibits canine gastric acid secretion in response to pentagastrin by modulating gastric histamine release.

Journal: The Journal of pharmacology and experimental therapeutics 19961101

Title: Pentagastrin has panic-inducing properties in obsessive compulsive disorder.

Journal: Psychopharmacology 19960801

Title: Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH2 derivatives.

Journal: Bioorganic & medicinal chemistry 19960401

Title: Comparison of cholecystokinin, pentagastrin, and duodenal oleate in gastroprotection in rats.

Journal: Scandinavian journal of gastroenterology 19950701

Title: Cholecystokinin and anxiety in normal volunteers: an investigation of the anxiogenic properties of pentagastrin and reversal by the cholecystokinin receptor subtype B antagonist L-365,260.

Journal: British journal of clinical pharmacology 19950301

Title: Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.

Journal: Molecular pharmacology 19941101

Title: Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists.

Journal: European journal of pharmacology 19940912

Title: Dissociated effect of nicotine on pentagastrin-stimulated acid secretion and blood flow in the rat stomach.

Journal: Scandinavian journal of gastroenterology 19940901

Title: Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 19940501

Title: Cholecystokinin dipeptoid antagonists: design, synthesis, and anxiolytic profile of some novel CCK-A and CCK-B selective and 'mixed' CCK-A/CCK-B antagonists.

Journal: Journal of medicinal chemistry 19930305

Title: Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogs.

Journal: Japanese journal of pharmacology 19910401

Title: Distribution of distances in thiopeptides by fluorescence energy transfer and frequency-domain fluorometry.

Journal: Biophysical chemistry 19881001

Title: Stimulating effect of pentagastrin on cancer cell proliferation kinetics in chemically induced colon cancer in rats.

Journal: Regulatory peptides 19880101

Title: Phospholipid structure determines the effects of peptides on membranes. Differential scanning calorimetry studies with pentagastrin-related peptides.

Journal: Biochimica et biophysica acta 19860414

Title: Gastrin stimulates growth of colon cancer.

Journal: Surgery 19860301

Title: Synthesis of the C-terminal octapeptide of pig oxyntomodulin. Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala: a potent inhibitor of pentagastrin-induced acid secretion.

Journal: Journal of medicinal chemistry 19851001

Title: Effects of enkephalins and their analogs on gastric secretion.

Journal: Neuroscience and behavioral physiology 19840101

Title: Atrial fibrillation after administration of calcium and pentagastrin.

Journal: The New England journal of medicine 19810604

Title: The role of beta1- and beta2-adrenoceptors in the inhibition of gastric acid secretion in the dog.

Journal: British journal of pharmacology 19780901

Title: [Subjective tolerance of pentagastrin test (author's transl)].

Journal: Leber, Magen, Darm 19780601

Title: Colchicine inhibits stimulated release of gastric histamine but not activation of histidine decarboxylase.

Journal: Experientia 19770315

Title: Mechanism of action of pentagastrin and acetylcholine on the longitudinal muscle of the canine antrum.

Journal: The Journal of physiology 19751101

Title: Specific tritiation of indole derivatives by catalytic desulfenylation. Application to the labelling of tryptophan-containing peptides.

Journal: European journal of biochemistry 19750102

Title: A study of the effect of betahistine on gastric acid secretion in man.

Journal: Current medical research and opinion 19740101

Title: Smith AJ, et al. Characterisation of CCKB receptors on GH3 pituitary cells: receptor activation is linked to Ca2+ mobilisation. Eur J Pharmacol. 1994 Apr 15;267(2):215-23.

Title: Tanaka S, et al. Pentagastrin gastroprotection against acid is related to H2 receptor activation but not acid secretion. Gut. 1998 Sep;43(3):334-41.

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Tags:5534-95-2 Molecular Formula|5534-95-2 MDL|5534-95-2 SMILES|5534-95-2 PENTAGASTRIN