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1947-37-1,MFCD31630712
Catalog No.:AA00AK4Y

1947-37-1 | TETRAGASTRIN

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AK4Y
Chemical Name:
TETRAGASTRIN
CAS Number:
1947-37-1
Molecular Formula:
C29H36N6O6S
Molecular Weight:
596.6977
MDL Number:
MFCD31630712
SMILES:
CSCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)N
Properties
Computed Properties
 
Complexity:
948  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
16  
XLogP3:
-2.1  

Literature

Title: Differential effects to CCK-4-induced panic by dexamethasone and hydrocortisone.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20121001

Title: Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115.

Journal: Bulletin of experimental biology and medicine 20121001

Title: CCK-B receptor gene and response to cholecystokinin-tetrapeptide in healthy volunteers.

Journal: Peptides 20120501

Title: Feeding-suppressive mechanism of sulfated cholecystokinin (26-33) in chicks.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20120401

Title: Experimental panic provocation in healthy man-a translational role in anti-panic drug development?

Journal: Dialogues in clinical neuroscience 20111201

Title: A sucrose-derived scaffold for multimerization of bioactive peptides.

Journal: Bioorganic & medicinal chemistry 20111101

Title: Solid-phase extraction-field-amplified sample injection coupled with CE-ESI-MS for online pre-concentration and quantitative analysis of brain-gut peptides.

Journal: Electrophoresis 20111001

Title: New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R).

Journal: Journal of medicinal chemistry 20110825

Title: Quantitative distribution of brush cells in the rat gastrointestinal tract: brush cell population coincides with NaHCO3 secretion.

Journal: Medical molecular morphology 20110301

Title: One milligram of lorazepam does not decrease anxiety induced by CCK-4 in healthy volunteers: investigation of neural correlates with BOLD MRI.

Journal: Journal of psychopharmacology (Oxford, England) 20110101

Title: Glyoxalase-I mRNA expression and CCK-4 induced panic attacks.

Journal: Journal of psychiatric research 20110101

Title: [The absence of tolerance and withdrawal syndrome after the treatment with the new L-tryptophane-containing dipeptide anxiolytic GB-115].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20110101

Title: [Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: CCK-4: Psychophysiological conditioning elicits features of spontaneous panic attacks.

Journal: Journal of psychiatric research 20101201

Title: Solid-state stability studies of cholecystokinin (CCK-4) peptide under nonisothermal conditions using thermal analysis, chromatography and mass spectrometry.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100219

Title: Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting.

Journal: European journal of medicinal chemistry 20100201

Title: Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations.

Journal: Psychoneuroendocrinology 20091101

Title: The acute antipanic and anxiolytic activity of aerobic exercise in patients with panic disorder and healthy control subjects.

Journal: Journal of psychiatric research 20090801

Title: Cholecystokinin action on layer 6b neurons in somatosensory cortex.

Journal: Brain research 20090728

Title: Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.

Journal: Science (New York, N.Y.) 20090724

Title: CCK-4-induced anxiety but not panic is associated with serum brain-derived neurotrophic factor in healthy subjects.

Journal: Journal of psychopharmacology (Oxford, England) 20090601

Title: Effects of experimentally induced panic attacks on neuroimmunological markers.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20090601

Title: The selective serotonin re-uptake inhibitor escitalopram modulates the panic response to cholecystokinin tetrapeptide in healthy men depending on 5-HTTLPR genotype.

Journal: Journal of psychiatric research 20090301

Title: Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers.

Journal: Human brain mapping 20090201

Title: Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4.

Journal: Journal of psychiatric research 20090101

Title: Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.

Journal: Neuroscience letters 20081203

Title: Impact of state and trait anxiety on the panic response to CCK-4.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080601

Title: Hydrolysis of various bioactive peptides by goat brain dipeptidylpeptidase-III homologue.

Journal: Cell biochemistry and function 20080401

Title: Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection.

Journal: Bulletin of experimental biology and medicine 20080301

Title: Validation of respiratory safety pharmacology models: conscious and anesthetized beagle dogs.

Journal: Journal of pharmacological and toxicological methods 20080101

Title: Independent component analysis applied to pharmacological magnetic resonance imaging (phMRI): new insights into the functional networks underlying panic attacks as induced by CCK-4.

Journal: Current pharmaceutical design 20080101

Title: Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and [3H]GABA release.

Journal: The European journal of neuroscience 20071201

Title: Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons.

Journal: Journal of neurophysiology 20070901

Title: Cholecystokinin-2 receptors modulate freezing and escape behaviors evoked by the electrical stimulation of the rat dorsolateral periaqueductal gray.

Journal: Brain research 20070702

Title: Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study.

Journal: Psychopharmacology 20070701

Title: Effects of repetitive transcranial magnetic stimulation (rTMS) on panic attacks induced by cholecystokinin-tetrapeptide (CCK-4).

Journal: The international journal of neuropsychopharmacology 20070401

Title: Long-lasting changes of albino rats behavior and brain bioamines content after immunization against cholecystokinin-3 and -4.

Journal: Neurochemical research 20070301

Title: Blockade of the mineralocorticoid receptor in healthy men: effects on experimentally induced panic symptoms, stress hormones, and cognition.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070101

Title: [Design and synthesis of cholecystokinin-4 dipeptide analogues with anxiolytic and anxiogenic activities].

Journal: Bioorganicheskaia khimiia 20070101

Title: Lack of interaction between NMDA and cholecystokinin-2 receptor-mediated neurotransmission in the dorsolateral periaqueductal gray in the regulation of rat defensive behaviors.

Journal: Life sciences 20061102

Title: Data analysis of kinetic modelling used in drug stability studies: isothermal versus nonisothermal assays.

Journal: Pharmaceutical research 20061101

Title: An immunochemical approach to model and long-term suppression of depressive and anxiety behavior.

Journal: The Spanish journal of psychology 20061101

Title: Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety.

Journal: NeuroImage 20060701

Title: Tryptophan depletion does not modify response to CCK-4 challenge in patients with panic disorder after treatment with citalopram.

Journal: Psychopharmacology 20060501

Title: Megestrol attenuates the hormonal response to CCK-4-induced panic attacks.

Journal: Depression and anxiety 20060101

Title: Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

Journal: Journal of medicinal chemistry 20051201

Title: The acute antipanic activity of aerobic exercise.

Journal: The American journal of psychiatry 20051201

Title: Involvement of dorsolateral periaqueductal gray cholecystokinin-2 receptors in the regulation of a panic-related behavior in rats.

Journal: Brain research 20051012

Title: Cholecystokinin tetrapeptide effects on HPA axis function and elevated plus maze behaviour in maternally separated and handled rats.

Journal: Behavioural brain research 20050620

Title: Differential spatial approximation between cholecystokinin residue 30 and receptor residues in active and inactive conformations.

Journal: Molecular pharmacology 20050601

Title: Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results.

Journal: Psychopharmacology 20050401

Title: Panic induction with cholecystokinin-tetrapeptide (CCK-4) Increases plasma concentrations of the neuroactive steroid 3alpha, 5alpha tetrahydrodeoxycorticosterone (3alpha, 5alpha-THDOC) in healthy volunteers.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050101

Title: Randomized, double-blind study of SR142801 (Osanetant). A novel neurokinin-3 (NK3) receptor antagonist in panic disorder with pre- and posttreatment cholecystokinin tetrapeptide (CCK-4) challenges.

Journal: Pharmacopsychiatry 20050101

Title: [Biological activity of cholecystokinin-(30-33) tetrapeptide analogs].

Journal: Bioorganicheskaia khimiia 20050101

Title: Central cholecystokinin activity in irritable bowel syndrome, panic disorder, and healthy controls.

Journal: Psychosomatic medicine 20050101

Title: Cholecystokinin tetrapeptide improves water maze performance of neonatally 6-hydroxydopamine-lesioned young rats.

Journal: Pharmacology, biochemistry, and behavior 20040901

Title: Sensitivity to cholecystokinin-tetrapeptide in major depression.

Journal: Journal of affective disorders 20040601

Title: The effect of 5-hydroxytryptophan on cholecystokinin-4-induced panic attacks in healthy volunteers.

Journal: Journal of psychopharmacology (Oxford, England) 20040601

Title: Analysis of strain difference in behavior to Cholecystokinin (CCK) receptor mediated drugs in PVG hooded and Sprague-Dawley rats using elevated plus-maze test apparatus.

Journal: Neuroscience letters 20040401

Title: Neuroactive steroids are not affected by panic induction with 50 microg cholecystokinin-tetrapeptide (CCK-4) in healthy volunteers.

Journal: Journal of psychiatric research 20040101

Title: Effects of CCK-tetrapeptide in patients with social phobia and obsessive-compulsive disorder.

Journal: Depression and anxiety 20040101

Title: Cholecystokinin antagonists: pharmacological and therapeutic potential.

Journal: Medicinal research reviews 20030901

Title: Acute effects of cholecystokinin tetrapeptide on brain stem auditory evoked potentials in healthy volunteers.

Journal: Pharmacopsychiatry 20030901

Title: Differential startle reactivity following central CCK-8S and systemic Boc CCK-4 administration in mice: antecedent stressor history and testing condition.

Journal: Behavioral neuroscience 20030801

Title: Molecular cloning of an unusual bicistronic cholecystokinin receptor mRNA expressed in chicken brain: a structural and functional expression study.

Journal: Regulatory peptides 20030615

Title: Neutrophil-derived hydroxyl radicals mediate interleukin-8-induced increases in tetragastrin-stimulated acid secretion in rats.

Journal: Digestive diseases and sciences 20030601

Title: Effect of peripheral cholecystokinin receptor agonists on c-Fos expression in brain sites mediating food consumption in rats.

Journal: Neuroscience letters 20030529

Title: Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled study.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030501

Title: Enzymatic synthesis of a CCK-4 tripeptide fragment.

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030401

Title: Genetic variations in CCK2 receptor in PVG hooded and Sprague-Dawley rats and its mRNA expression on cat exposure.

Journal: Behavioral neuroscience 20030401

Title: Cholecystokinin induces cerebral vasodilatation via presynaptic CCK2 receptors: new implications for the pathophysiology of panic.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030301

Title: Endogenous CCK depresses contractile activity within the ascending myenteric reflex pathway of rat ileum.

Journal: Neuropharmacology 20030301

Title: Plasma gamma-amino-butyric acid (GABA) levels in cholecystokinine-tetrapeptide (CCK-4) induced anxiety.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030301

Title: Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results.

Journal: Archives of general psychiatry 20030201

Title: Effects of cholecystokinin tetrapeptide (CCK(4)) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats.

Journal: Neurochemistry international 20030101

Title: Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers.

Journal: Depression and anxiety 20030101

Title: Absorption of biologically active peptide hormones from the small intestine of rat.

Journal: Acta physiologica Scandinavica 20021101

Title: Aging and panicogenic response to cholecystokinin tetrapeptide: an examination of the cholecystokinin system.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021001

Title: Acute cholecystokinin effects on event-related potentials in healthy volunteers.

Journal: Human psychopharmacology 20020801

Title: The ventilatory response to cholecystokinin tetrapeptide in healthy volunteers.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020601

Title: Anxiogenic effects of the CCK(B) agonist pentagastrin in humans and dose-dependent increase in plasma C-peptide levels.

Journal: Psychopharmacology 20020601

Title: 2-Oxopiperazine-based gamma-turn conformationally constrained peptides: synthesis of CCK-4 analogues.

Journal: The Journal of organic chemistry 20020531

Title: Intestinal metabolism and absorption of cholecystokinin analogs in rats.

Journal: Biochemical and biophysical research communications 20020405

Title: Differential effects of the CCKA receptor ligands PD-140,548 and A-71623 on latent inhibition in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020401

Title: Transcranial magnetic stimulation for panic.

Journal: The American journal of psychiatry 20020201

Title: Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men.

Journal: Journal of psychiatric research 20020101

Title: The effects of immunization against cholecystokinin fragment 30-33 in the behavior of white rats.

Journal: Neuroscience and behavioral physiology 20020101

Title: Synthesis of cholecystokinin peptide CCK-4 exclusively by enzymatic methods.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101

Title: Effects of cholecystokinin tetrapeptide (CCK(4)) and anxiolytic drugs on the electrically evoked [(3)H]5-hydroxytryptamine outflow from rat cortical slices.

Journal: Brain research 20011213

Title: Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101

Title: 99mTc-labeling experiments on CCK(4) by a direct method.

Journal: Nuclear medicine and biology 20011001

Title: Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder.

Journal: The American journal of psychiatry 20010901

Title: The influence of Type A behavior pattern on the response to the panicogenic agent CCK-4.

Journal: Journal of psychosomatic research 20010901

Title: Strain differences in freezing behavior of PVG hooded and Sprague-Dawley rats: differential cortical expression of cholecystokinin2 receptors.

Journal: Neuroreport 20010828

Title: Cholecystokinin modulation of apomorphine- or amphetamine-induced stereotypy in rats: opposite effects.

Journal: Peptides 20010801

Title: Stimulation of either cholecystokinin receptor subtype reduces while antagonists potentiate or sensitize a morphine-induced excitatory response.

Journal: Peptides 20010801

Title: Arginine-vasopressin and oxytocin response to cholecystokinin-tetrapeptide.

Journal: Peptides 20010801

Title: Inhibition of gastric acid secretion by saiboku-to, an oriental herbal medicine, in rats.

Journal: Digestive diseases and sciences 20010501

Title: Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings.

Journal: Archives of general psychiatry 20010401

Title: Depressive symptoms in hypothyroid disorder with some observations on biochemical correlates.

Journal: Neuropsychobiology 20010101

Title: In healthy volunteers responses to challenge with cholecystokinin tetrapeptide differ between administration during REM and delta sleep.

Journal: Depression and anxiety 20010101

Title: Cholecystokinin and panic disorder: past and future clinical research strategies.

Journal: Scandinavian journal of clinical and laboratory investigation. Supplementum 20010101

Title: Mimicry of beta II'-turns of proteins in cyclic pentapeptides with one and without D-amino acids.

Journal: European journal of biochemistry 19990201

Title: Second generation 'peptoid' CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile.

Journal: Journal of medicinal chemistry 19980101

Title: Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.

Journal: Journal of medicinal chemistry 19970227

Title: Pharmacological characterization of a Chinese hamster ovary cell line transfected with the human CCK-B receptor gene.

Journal: Neuropeptides 19960801

Title: His381 of the rat CCKB receptor is essential for CCKB versus CCKA receptor antagonist selectivity.

Journal: European journal of pharmacology 19960118

Title: Behavioral effects of A71623, a highly selective CCK-A agonist tetrapeptide.

Journal: The American journal of physiology 19920701

Title: [Conformational-functional relationships of tetragastrin analogs].

Journal: Bioorganicheskaia khimiia 19910501

Title: Conformational analysis of possible biologically active (receptor-bound) conformations of peptides derived from cholecystokinin, cerulein and little gastrin and the opiate peptide, Met-enkephalin.

Journal: Peptides 19880101

Title: Phenylethylamide derivatives of the C-terminal tetrapeptide of gastrin. Potent inhibitors of gastrin-stimulated acid secretion.

Journal: International journal of peptide and protein research 19861101

Title: A behavioral pharmacological study on CCK-8 related peptides in mice.

Journal: Neuropeptides 19861001

Title: Degradation of cholecystokinin-like peptides by a crude rat brain synaptosomal fraction: a study by high pressure liquid chromatography.

Journal: Regulatory peptides 19810401

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Tags:1947-37-1 Molecular Formula|1947-37-1 MDL|1947-37-1 SMILES|1947-37-1 TETRAGASTRIN