Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal20130415
Title: Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action.
Journal: Neuroscience20121213
Title: Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
Journal: Journal of medicinal chemistry20121108
Title: Roles of glycogen synthase kinase 3 in Alzheimer's disease.
Journal: Current Alzheimer research20120901
Title: Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA20120901
Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20120523
Title: Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine.
Journal: Journal of gastroenterology20120301
Title: Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
Journal: Bioorganic & medicinal chemistry letters20120301
Title: Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.
Journal: Journal of medicinal chemistry20111222
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology20111101
Title: Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.
Journal: Bioorganic & medicinal chemistry letters20110915
Title: Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.
Journal: The international journal of neuropsychopharmacology20110901
Title: Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation.
Journal: Toxicological sciences : an official journal of the Society of Toxicology20110901
Title: Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFκB via suppression of GSK-3β expression.
Journal: Cancer biology & therapy20110815
Title: Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1.
Journal: Biochimie20110701
Title: Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin.
Journal: The Journal of investigative dermatology20110701
Title: Glycogen synthase kinase-3β is a functional modulator of serotonin-1B receptors.
Journal: Molecular pharmacology20110601
Title: The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
Journal: The journal of pain : official journal of the American Pain Society20110301
Title: Glycogen synthase kinase-3β indirectly facilitates interferon-γ-induced nuclear factor-κB activation and nitric oxide biosynthesis.
Journal: Journal of cellular biochemistry20101215
Title: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone.
Journal: Chemico-biological interactions20101006
Title: Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.
Journal: Cellular and molecular neurobiology20100801
Title: A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors.
Journal: Proceedings of the National Academy of Sciences of the United States of America20100622
Title: Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor.
Journal: Peptides20100601
Title: Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells.
Journal: The American journal of pathology20100201
Title: Cardioprotection leads to novel changes in the mitochondrial proteome.
Journal: American journal of physiology. Heart and circulatory physiology20100101
Title: Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.
Journal: British journal of cancer20091215
Title: Glycogen synthase kinase-3beta (GSK-3beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons.
Journal: Journal of neurovirology20091201
Title: CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta.
Journal: Journal of immunology (Baltimore, Md. : 1950)20091115
Title: Inhibition of endothelial progenitor cell glycogen synthase kinase-3beta results in attenuated neointima formation and enhanced re-endothelialization after arterial injury.
Journal: Cardiovascular research20090701
Title: Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.
Journal: European journal of medicinal chemistry20090601
Title: Exploring complex protein-ligand recognition mechanisms with coarse metadynamics.
Journal: The journal of physical chemistry. B20090409
Title: Epithelial cell survival by activating transcription factor 3 (ATF3) in response to chemical ribosome-inactivating stress.
Journal: Biochemical pharmacology20090315
Title: Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.
Journal: Neuropharmacology20090201
Title: Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20090201
Title: Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
Journal: Cancer research20081001
Title: Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice.
Journal: Progress in neuro-psychopharmacology & biological psychiatry20080801
Title: Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
Journal: Biochemical and biophysical research communications20080711
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America20071218
Title: The selectivity of protein kinase inhibitors: a further update.
Journal: The Biochemical journal20071215
Title: Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells.
Journal: Neuropharmacology20070801
Title: Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
Journal: Experimental neurology20070601
Title: Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity.
Journal: Neuropharmacology20070601
Title: Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20060901
Title: The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.
Journal: IDrugs : the investigational drugs journal20060101
Title: Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.
Journal: Bioorganic & medicinal chemistry letters20051201
Title: Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.
Journal: Cancer research20050315
Title: AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.
Journal: The international journal of neuropsychopharmacology20041201
Title: GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila.
Journal: Molecular psychiatry20040501
Title: Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
Journal: The Journal of biological chemistry20031114
Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Journal: Diabetes20000201
Title: Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Journal: Diabetes19990801
Title: Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.
Journal: Proceedings of the National Academy of Sciences of the United States of America19930815
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