+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
529488-28-6,MFCD25976816
Catalog No.:AA00DB3E

529488-28-6 | Genz-644282

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$58.00   $40.00
- +
5mg
99%
in stock  
$244.00   $171.00
- +
25mg
95%
in stock  
$252.00   $177.00
- +
100mg
95%
in stock  
$601.00   $421.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DB3E
Chemical Name:
Genz-644282
CAS Number:
529488-28-6
Molecular Formula:
C22H21N3O5
Molecular Weight:
407.4192
MDL Number:
MFCD25976816
SMILES:
CNCCn1c(=O)c2cc(OC)c(cc2c2c1c1cc3OCOc3cc1nc2)OC
Properties
Computed Properties
 
Complexity:
636  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

Literature

Title: Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program.

Journal: Pediatric blood & cancer 20120201

Title: Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.

Journal: Molecular cancer therapeutics 20110801

Title: Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110501

Title: 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.

Journal: Journal of medicinal chemistry 20050210

Title: Kurtzberg LS, et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87.

Title: Houghton PJ, et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb;58(2):200-9.

Title: Sooryakumar D, et al. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 529488-28-6
Building Blocks
More >
Tags:529488-28-6 Molecular Formula|529488-28-6 MDL|529488-28-6 SMILES|529488-28-6 Genz-644282
Catalog No.: AA00DB3E
529488-28-6,MFCD25976816
529488-28-6 | Genz-644282
Pack Size： 1mg
Purity： ≥98%
in stock
$58.00 $40.00
Pack Size： 5mg
Purity： 99%
in stock
$244.00 $171.00
Pack Size： 25mg
Purity： 95%
in stock
$252.00 $177.00
Pack Size： 100mg
Purity： 95%
in stock
$601.00 $421.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00DB3E
Chemical Name: Genz-644282
CAS Number: 529488-28-6
Molecular Formula: C22H21N3O5
Molecular Weight: 407.4192
MDL Number: MFCD25976816
SMILES: CNCCn1c(=O)c2cc(OC)c(cc2c2c1c1cc3OCOc3cc1nc2)OC
Properties
Complexity: 636  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 5  
XLogP3: 2.2  
Downstream Synthesis Route
847573-86-8    529488-28-6 

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

61203-48-3    529488-28-6 

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

28657-75-2    529488-28-6 

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

113258-92-7    529488-28-6 

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

59134-89-3    529488-28-6 

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

Literature fold

Title: Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program.

Journal: Pediatric blood & cancer20120201

Title: Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.

Journal: Molecular cancer therapeutics20110801

Title: Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20110501

Title: 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.

Journal: Journal of medicinal chemistry20050210

Title: Kurtzberg LS, et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87.

Title: Houghton PJ, et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb;58(2):200-9.

Title: Sooryakumar D, et al. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9.

Related Products of of 529488-28-6
Building Blocks More >
474708-88-8
474708-88-8
6-Bromo-8-chloroimidazo[1,2-a]pyridine
AA00DB7I | MFCD11518983
50914-15-3
50914-15-3
(2-Iodophenyl)hydrazine
AA00DBCI | MFCD02656658
4333-62-4
4333-62-4
1,3-Dimethylimidazolium iodide
AA00DBHH | MFCD04114549
52898-49-4
52898-49-4
4,N-Dimethoxy-N-methylbenzamide
AA00DBOJ | MFCD02684314
4378-43-2
4378-43-2
4-Phosphonobutyric acid
AA00DBW0 | MFCD00041414
486422-19-9
486422-19-9
1-[(3-Bromobenzene)sulfonyl]-4-methylpiperazine
AA00DC32 | MFCD10000772
86389-83-5
86389-83-5
1,2-Benzenediol, 4-(2-aminoethyl)-, homopolymer
AA01X3QC | MFCD00130258
53648-55-8
53648-55-8
Dezocine
AA00DCHU | MFCD00287274
447412-24-0
447412-24-0
2-Amino-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carbonitrile
AA00DCM4 | MFCD02934381
5589-97-9
5589-97-9
3-(3,5-Dimethyl-1h-pyrazol-1-yl)propanenitrile
AA00DCQS | MFCD00462195
Submit
© 2017 AA BLOCKS, INC. All rights reserved.