Title: IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes.
Journal: Archives of toxicology20170501
Title: Combined blockade of signalling pathways shows marked anti-tumour potential in phaeochromocytoma cell lines.
Journal: Journal of molecular endocrinology20121001
Title: K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas.
Journal: Cancer letters20120901
Title: Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma.
Journal: Molecular cancer research : MCR20120601
Title: Factors influencing the inhibition of protein kinases.
Journal: Journal of enzyme inhibition and medicinal chemistry20120401
Title: Insulin-like growth factor-1 boosts the developing process of condylar hyperplasia by stimulating chondrocytes proliferation.
Journal: Osteoarthritis and cartilage20120401
Title: Polo-like kinase 1 inhibition as a new therapeutic modality in therapy of cholangiocarcinoma.
Journal: Anticancer research20111001
Title: Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β.
Journal: Molecular cancer therapeutics20110801
Title: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.
Journal: Cellular oncology (Dordrecht)20110601
Title: Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines.
Journal: Gynecologic oncology20110501
Title: Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma.
Journal: Molecular cancer therapeutics20110401
Title: Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20110101
Title: Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease.
Journal: Cancer letters20100901
Title: Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines.
Journal: International journal of oncology20100901
Title: Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20100601
Title: Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance.
Journal: World journal of gastroenterology20100114
Title: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.
Journal: Analytical cellular pathology (Amsterdam)20100101
Title: Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression.
Journal: Cancer letters20090908
Title: Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin.
Journal: Carcinogenesis20090801
Title: Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.
Journal: Cancer research20090515
Title: Dependence on PI3K/Akt signaling for malignant rhabdoid tumor cell survival.
Journal: Cancer chemotherapy and pharmacology20090401
Title: Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by Rad001.
Journal: Anti-cancer drugs20090401
Title: Synergic antitumoral effect of an IGF-IR inhibitor and trastuzumab on HER2-overexpressing breast cancer cells.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20081101
Title: Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas.
Journal: Molecular cancer therapeutics20080601
Title: The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.
Journal: British journal of haematology20080501
Title: Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
Journal: Journal of cellular biochemistry20071215
Title: The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion.
Journal: Leukemia20070501
Title: Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20070215
Title: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer.
Journal: World journal of gastroenterology20060921
Title: Paradoxical effects of the phage display-derived peptide antagonist IGF-F1-1 on insulin-like growth factor-1 receptor signaling.
Journal: Biochemical pharmacology20060628
Title: Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells.
Journal: Biochemical pharmacology20060514
Title: The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours.
Journal: Endocrine-related cancer20060301
Title: Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin prevents synovial sarcoma proliferation via apoptosis in in vitro models.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20050801
Title: Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.
Journal: Cancer research20050501
Title: In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.
Journal: Cancer cell20040301
Title: Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma.
Journal: Molecular endocrinology (Baltimore, Md.)
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