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Home Amines 444731-52-6
444731-52-6,MFCD11616589
Catalog No.:AA00DE2I

444731-52-6 | 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
99%
in stock  
$11.00   $8.00
- +
250mg
99%
in stock  
$26.00   $18.00
- +
10g
98%
in stock  
$1,009.00   $706.00
- +
25g
98%
in stock  
$2,007.00   $1,405.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DE2I
Chemical Name:
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide
CAS Number:
444731-52-6
Molecular Formula:
C21H23N7O2S
Molecular Weight:
437.5180
MDL Number:
MFCD11616589
SMILES:
CN(c1ccc2c(c1)nn(c2C)C)c1ccnc(n1)Nc1ccc(c(c1)S(=O)(=O)N)C
NSC Number:
752782
Properties
Computed Properties
 
Complexity:
717  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2011/58179,2011,A1Locationinpatent:Page/Pagecolumn9

444731-75-3   
pazopanib 

[1]Patent:WO2011/69053,2011,A1

[2]LettersinOrganicChemistry,2012,vol.9,p.276-279

[3]Patent:EP2311825,2015,B1

6973-09-7   
pazopanib 

[1]Patent:WO2011/69053,2011,A1

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2011/69053,2011,A1Locationinpatent:Page/Pagecolumn33

[2]Locationinpatent:experimentalpartMei,YiCheng;Yang,BaoWei;Chen,Wei;Huang,DanDan;Li,Ying;Deng,Xin;Liu,BaoMing;Wang,JingJie;Qian,Hai;Huang,WenLong[LettersinOrganicChemistry,2012,vol.9,#4,p.276-279]

[3]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-EP2311825,2015,B1Locationinpatent:Paragraph0345-0346

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2011/69053,2011,A1Locationinpatent:Page/Pagecolumn31

Literature

Title: Harris PA, et al. Discovery of 5-[-[(2,3-dimethyl-2H-indazol-6-yl)methylamino-2-pyrimidinylamino-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51(15), 4632-4640.

Title: Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82(3):346-50.

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SDS
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Tags:444731-52-6 Molecular Formula|444731-52-6 MDL|444731-52-6 SMILES|444731-52-6 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide