Home Other Building Blocks 470-42-8
470-42-8,MFCD01740864
Catalog No.:AA00DHKM

470-42-8 | marinobufagenin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$153.00   $107.00
- +
5mg
≥98%
in stock  
$668.00   $467.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DHKM
Chemical Name:
marinobufagenin
CAS Number:
470-42-8
Molecular Formula:
C24H32O5
Molecular Weight:
400.5079
MDL Number:
MFCD01740864
SMILES:
O[C@H]1CC[C@]2([C@](C1)(O)CC[C@@H]1[C@@H]2CC[C@]2([C@]31O[C@@H]3C[C@@H]2c1ccc(=O)oc1)C)C
NSC Number:
234205
Properties
Computed Properties
 
Complexity:
833  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
2.5  

Literature

Title: Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts.

Journal: Physiological genomics 20160301

Title: Marinobufagenin predicts and resibufogenin prevents preeclampsia: a review of the evidence.

Journal: American journal of perinatology 20121101

Title: Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump.

Journal: Journal of hypertension 20120901

Title: Pathogenesis of pre-eclampsia: marinobufagenin and angiogenic imbalance as biomarkers of the syndrome.

Journal: Translational research : the journal of laboratory and clinical medicine 20120801

Title: Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure.

Journal: American journal of hypertension 20120601

Title: Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis.

Journal: The Journal of biological chemistry 20120511

Title: DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase.

Journal: American journal of hypertension 20120401

Title: Marinobufagenin and cyclic strain may activate endothelial NADPH oxidase, contributing to the adverse impact of salty diets on vascular and cerebral health.

Journal: Medical hypotheses 20120201

Title: Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia.

Journal: Hypertension in pregnancy 20120101

Title: Systemic hypertension: the roles of salt, vascular Na+/K+ ATPase and the endogenous glycosides, ouabain and marinobufagenin.

Journal: Cardiology in review 20120101

Title: Endogenous cardiotonic steroids in chronic renal failure.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901

Title: Marinobufagenin levels in preeclamptic patients: a preliminary report.

Journal: American journal of perinatology 20110801

Title: Both high and low maternal salt intake in pregnancy alter kidney development in the offspring.

Journal: American journal of physiology. Renal physiology 20110801

Title: Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation.

Journal: Life sciences 20110103

Title: Marinobufagenin is an upstream modulator of Gadd45a stress signaling in preeclampsia.

Journal: Biochimica et biophysica acta 20110101

Title: A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids.

Journal: Journal of immunoassay & immunochemistry 20110101

Title: The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking.

Journal: Biochimica et biophysica acta 20101201

Title: Marinobufagenin, resibufogenin and preeclampsia.

Journal: Biochimica et biophysica acta 20101201

Title: Renal ischemia regulates marinobufagenin release in humans.

Journal: Hypertension (Dallas, Tex. : 1979) 20101101

Title: Emerging role of the bufadienolides in cardiovascular and kidney diseases.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20100801

Title: Low-dose cardiotonic steroids increase sodium-potassium ATPase activity that protects hippocampal slice cultures from experimental ischemia.

Journal: Neuroscience letters 20100405

Title: The treatment of preeclampsia in a rat model employing Digibind.

Journal: American journal of perinatology 20100401

Title: Interaction of Digibind with endogenous cardiotonic steroids from preeclamptic placentae.

Journal: Journal of hypertension 20100201

Title: Contribution of angiogenic factors in a rat model of pre-eclampsia.

Journal: American journal of nephrology 20100101

Title: Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin.

Journal: Hypertension (Dallas, Tex. : 1979) 20091201

Title: Vascular leak in a rat model of preeclampsia.

Journal: American journal of nephrology 20090701

Title: Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive alpha1 Na+-K+-ATPase.

Journal: American journal of physiology. Heart and circulatory physiology 20090601

Title: Marinobufagenin causes endothelial cell monolayer hyperpermeability by altering apoptotic signaling.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090601

Title: Endogenous cardiotonic steroids and differential patterns of sodium pump inhibition in NaCl-loaded salt-sensitive and normotensive rats.

Journal: American journal of hypertension 20090501

Title: Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy.

Journal: American journal of physiology. Renal physiology 20090501

Title: Acute sodium loading in Dahl-s rats: alterations in renal and vascular sodium pump inhibition amidst unaltered cardiotonic steroid levels?

Journal: American journal of hypertension 20090501

Title: The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition.

Journal: American journal of physiology. Renal physiology 20090401

Title: Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension.

Journal: Journal of hypertension 20081201

Title: [Effect of nicotine on electrogenic contribution of the Na,K-ATPase isoforms and contractile characteristics of the rat skeletal muscle].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20081001

Title: Role of endogenous cardiotonic steroids in sodium homeostasis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080901

Title: Comparison of non-digitalis binding properties of digoxin-specific Fabs using direct binding methods.

Journal: Journal of immunological methods 20080731

Title: Effects of cardiotonic steroids on dermal collagen synthesis and wound healing.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20080701

Title: Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function.

Journal: The Journal of biological chemistry 20080627

Title: The death of ouabain-treated renal epithelial cells: evidence against anoikis occurrence.

Journal: Apoptosis : an international journal on programmed cell death 20080501

Title: Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080401

Title: Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells.

Journal: Placenta 20080301

Title: Partial nephrectomy as a model for uremic cardiomyopathy in the mouse.

Journal: American journal of physiology. Renal physiology 20080201

Title: Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080101

Title: Effects of resibufogenin in experimental hypertension.

Journal: American journal of nephrology 20080101

Title: Vascular effects of the bufodienolides.

Journal: Transactions of the American Clinical and Climatological Association 20080101

Title: Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

Journal: American journal of physiology. Cell physiology 20070801

Title: Marinobufagenin interferes with the function of the mineralocorticoid receptor.

Journal: Biochemical and biophysical research communications 20070518

Title: Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-1 cells, and its hypertensive effect in rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20070101

Title: Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy.

Journal: Hypertension (Dallas, Tex. : 1979) 20070101

Title: Endogenous Na/K-ATPase inhibitors in patients with preeclampsia.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20061230

Title: Marinobufagenin in hypertensive patients with obstructive sleep apnea.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20061230

Title: Atrial peptides modify the effect of marinobufagenin on sodium pumps: implications for blood pressure control.

Journal: Hypertension (Dallas, Tex. : 1979) 20061201

Title: ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta.

Journal: Hypertension (Dallas, Tex. : 1979) 20061201

Title: [Effects of marinobufagenin on electrophysiological and contractile characteristics of the rat diaphragm].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20061201

Title: The central role of the brain in salt-sensitive hypertension.

Journal: Current opinion in cardiology 20060701

Title: [Endogenous digitalis-like factor].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060701

Title: Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.

Journal: Hypertension (Dallas, Tex. : 1979) 20060301

Title: Cardiac glycosides and cardiomyopathy.

Journal: Hypertension (Dallas, Tex. : 1979) 20060301

Title: Resibufogenin corrects hypertension in a rat model of human preeclampsia.

Journal: Experimental biology and medicine (Maywood, N.J.) 20060201

Title: [Analysis of the interaction between nicotinic acetylcholine receptor and Na+,K(+)-ATPase in the rat skeletal muscle and the Torpedo electric organ membrane preparation].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20060201

Title: Marinobufagenin impairs first trimester cytotrophoblast differentiation.

Journal: Placenta 20060101

Title: [Role of the alpha2-isoform of Na+, K(+)-ATPase in the positive inotropic effect of ouabain and marinobufagenin in the rat diaphragm].

Journal: Biofizika 20060101

Title: Regulation of adrenocortical cardiotonic steroid production by dopamine and PKA signaling.

Journal: Frontiers in bioscience : a journal and virtual library 20050901

Title: Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer.

Journal: Seminars in nephrology 20050901

Title: Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl-loaded Dahl-S rats.

Journal: Journal of hypertension 20050801

Title: Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens.

Journal: Toxicon : official journal of the International Society on Toxinology 20050501

Title: Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells.

Journal: Kidney international 20050501

Title: Antibody to marinobufagenin lowers blood pressure in pregnant rats on a high NaCl intake.

Journal: Journal of hypertension 20050401

Title: A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure.

Journal: Clinical biochemistry 20050101

Title: Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium.

Journal: Medical hypotheses 20050101

Title: Marinobufagenin may mediate the adverse impact of salty diets on renal calcium retention by impairing the efficiency of renal tubular sodium-calcium exchange.

Journal: Medical hypotheses 20050101

Title: Involvement of marinobufagenin in a rat model of human preeclampsia.

Journal: American journal of nephrology 20050101

Title: Marinobufagenin, an endogenous inhibitor of alpha-1 Na/K-ATPase, is a novel factor in pathogenesis of diabetes mellitus.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20050101

Title: [Involvement of ouabain (digitalis-like factor) in the pathogenesis of hypertension and hypertensive target-organ damage].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040301

Title: Different effects of marinobufagenin and endogenous ouabain.

Journal: Journal of hypertension 20040201

Title: Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension.

Journal: Journal of hypertension 20040201

Title: Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium.

Journal: Medical hypotheses 20040101

Title: Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5.

Journal: Circulation 20031216

Title: Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat.

Journal: Kidney international 20030501

Title: Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20030301

Title: Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells.

Journal: Kidney international 20021201

Title: Marinobufagenin (MBG) suppression of ethanol-seeking behavior is associated with inhibition of brain cortex Na/K-ATPase in mice.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020601

Title: Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity.

Journal: Journal of hypertension 20020601

Title: Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension.

Journal: Circulation 20020305

Title: Phorbol diacetate potentiates na(+)-k(+) ATPase inhibition by a putative endogenous ligand, marinobufagenin.

Journal: Hypertension (Dallas, Tex. : 1979) 20020201

Title: Racial differences in resting end-tidal CO2 and circulating sodium pump inhibitor.

Journal: American journal of hypertension 20010801

Title: Interaction of NaCl and behavioral stress on endogenous sodium pump ligands in rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010701

Title: [Effect of marinobufagenin on the primary reinforcing effect of ethanol].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010501

Title: Abnormalities of sodium pump function in hypertension and the role of endogenous cardiotonic steroids.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20010301

Title: Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20010201

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:470-42-8 Molecular Formula|470-42-8 MDL|470-42-8 SMILES|470-42-8 marinobufagenin