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465-21-4,MFCD00056525
Catalog No.:AA00I8HZ

465-21-4 | Bufalin

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10mg
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25mg
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50mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I8HZ
Chemical Name:
Bufalin
CAS Number:
465-21-4
Molecular Formula:
C23H32O4
Molecular Weight:
372.4978
MDL Number:
MFCD00056525
SMILES:
O[C@H]1CC[C@H]2[C@@H](C1)CC[C@H]1[C@@H]2CC[C@]2([C@@]1(O)CC[C@H]2c1ccc(=O)oc1)C
Properties
Properties
 
BP:
556.6°C at 760 mmHg  
Form:
Solid  
MP:
242-243°  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
741  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.2  

Literature

Title: Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.

Journal: Toxicology letters 20180915

Title: Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo.

Journal: Environmental toxicology 20170401

Title: Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways.

Journal: Environmental toxicology 20150101

Title: A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides.

Journal: The Journal of antimicrobial chemotherapy 20140401

Title: A bufadienolide derived androgen receptor antagonist with inhibitory activities against prostate cancer cells.

Journal: Chemico-biological interactions 20140125

Title: Bufalin-inhibited migration and invasion in human osteosarcoma U-2 OS cells is carried out by suppression of the matrix metalloproteinase-2, ERK, and JNK signaling pathways.

Journal: Environmental toxicology 20140101

Title: Interaction of digitalis-like compounds with p-glycoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130201

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Ultrasound-assisted extraction of three bufadienolides from Chinese medicine ChanSu.

Journal: Ultrasonics sonochemistry 20121101

Title: AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells.

Journal: International journal of oncology 20121101

Title: Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis.

Journal: European journal of pharmacology 20121005

Title: Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.

Journal: Journal of cancer research and clinical oncology 20120801

Title: The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701

Title: [Study on proteomics of Hela cell apoptosis in bufalin-induced human cervical carcinoma].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120701

Title: [A comparison study of pharmacokinetics between bufalin-loaded bovine serum albumin nanoparticles and bufalin in rats].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20120601

Title: Natural compounds inhibiting the replication of Porcine reproductive and respiratory syndrome virus.

Journal: Antiviral research 20120501

Title: Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+-K+-ATPase-Src kinase pathway.

Journal: American journal of physiology. Renal physiology 20120415

Title: Cardenolides and bufadienolides as hormones: what is missing?

Journal: American journal of physiology. Renal physiology 20120415

Title: Attenuation of glomerular filtration barrier damage in adriamycin-induced nephropathic rats with bufalin: an antiproteinuric agent.

Journal: The Journal of steroid biochemistry and molecular biology 20120401

Title: Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells.

Journal: Mutation research 20120401

Title: Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells.

Journal: British journal of pharmacology 20120301

Title: Interacting impacts of invasive plants and invasive toads on native lizards.

Journal: The American naturalist 20120301

Title: Secohellebrigeninamide.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: Formation of new high density glycogen-microtubule structures is induced by cardiac steroids.

Journal: The Journal of biological chemistry 20120224

Title: Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK.

Journal: Molecular biology reports 20120201

Title: Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components.

Journal: Chemico-biological interactions 20120125

Title: Endogenous ouabain regulates cell viability.

Journal: American journal of physiology. Cell physiology 20120115

Title: Bufalin induces apoptosis through activation of both the intrinsic and extrinsic pathways in human bladder cancer cells.

Journal: Oncology reports 20120101

Title: Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway.

Journal: International journal of molecular sciences 20120101

Title: 'The Lower Threshold' phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis?

Journal: Journal of carcinogenesis 20120101

Title: Bufalin, a traditional oriental medicine, induces apoptosis in human cancer cells.

Journal: Asian Pacific journal of cancer prevention : APJCP 20120101

Title: Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling.

Journal: International journal of nephrology 20120101

Title: Triggering apoptotic death of human malignant melanoma a375.s2 cells by bufalin: involvement of caspase cascade-dependent and independent mitochondrial signaling pathways.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity.

Journal: International journal of nanomedicine 20120101

Title: Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression.

Journal: Acta haematologica 20120101

Title: Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research.

Journal: PloS one 20120101

Title: The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20111101

Title: The Na(+)/Ca(2+)-exchanger: an essential component in the mechanism governing cardiac steroid-induced slow Ca(2+) oscillations.

Journal: Cell calcium 20111101

Title: [Inhibitory effect of total bufadienolides from toad venom against H22 tumor in mice and their metabolites].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

Title: Bioadhesion and enhanced bioavailability by wheat germ agglutinin-grafted lipid nanoparticles for oral delivery of poorly water-soluble drug bufalin.

Journal: International journal of pharmaceutics 20111031

Title: Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.

Journal: Free radical biology & medicine 20111001

Title: Novel microbial transformation of resibufogenin by Fusarium solani.

Journal: Journal of Asian natural products research 20110901

Title: Effects of bufalin on the proliferation of human choriocarcinoma cells.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20110801

Title: Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways.

Journal: Cancer science 20110501

Title: Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway.

Journal: Apoptosis : an international journal on programmed cell death 20110401

Title: Na+/K+-ATPase α3 mediates sensitivity of hepatocellular carcinoma cells to bufalin.

Journal: Oncology reports 20110301

Title: Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor.

Journal: International immunopharmacology 20110301

Title: Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Cardiac glycosides are potent inhibitors of interferon-β gene expression.

Journal: Nature chemical biology 20110101

Title: Ex vivo activity of cardiac glycosides in acute leukaemia.

Journal: PloS one 20110101

Title: Bufalin inhibits platelet-derived growth factor-BB-induced mesangial cell proliferation through mediating cell cycle progression.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver.

Journal: International journal of nanomedicine 20110101

Title: Selective inhibition of the cellular sodium pump by emicymarin and 14ß anhydroxy bufadienolides.

Journal: Steroids 20101212

Title: Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action.

Journal: Cytotechnology 20101201

Title: Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection.

Journal: Journal of pharmaceutical and biomedical analysis 20101102

Title: Retraction of 'Effect of bufalin on proliferation and apoptosis of human non-small cell lung cancer A549 Cell. Zhongguo Fei Ai Za Zhi, 2010, 13(9): 841-845'.

Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20101101

Title: Delisheng, a Chinese medicinal compound, exerts anti-proliferative and pro-apoptotic effects on HepG2 cells through extrinsic and intrinsic pathways.

Journal: Molecular biology reports 20101001

Title: [Bufalin induces apoptosis in osteosarcoma U-2OS and U-2OS methotrexate 300-resistant cell lines in vitro].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20101001

Title: Wheat germ agglutinin-grafted lipid nanoparticles: preparation and in vitro evaluation of the association with Caco-2 monolayers.

Journal: International journal of pharmaceutics 20100915

Title: Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretion.

Journal: Toxicon : official journal of the International Society on Toxinology 20100901

Title: [Effect of Bufalin on proliferation and apoptosis of human non-small cell lung cancer A549 cell].

Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20100901

Title: Preparative separation of four major bufadienolides from the Chinese traditional medicine, Chansu, using high-speed counter-current chromatography.

Journal: Natural product communications 20100701

Title: Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase.

Journal: Acta pharmacologica Sinica 20100601

Title: Preparative separation and purification of bufadienolides from Chinese traditional medicine of ChanSu using high-speed counter-current chromatography.

Journal: Journal of separation science 20100501

Title: Ouabain attenuates cardiotoxicity induced by other cardiac steroids.

Journal: British journal of pharmacology 20100501

Title: Titanate-silica mesostructured nanocables: synthesis, structural analysis and biomedical applications.

Journal: Nanotechnology 20100210

Title: Na, K-ATPase: Ubiquitous Multifunctional Transmembrane Protein and its Relevance to Various Pathophysiological Conditions.

Journal: Journal of clinical medicine research 20100201

Title: An improved formulation screening and optimization method applied to the development of a self-microemulsifying drug delivery system.

Journal: Chemical & pharmaceutical bulletin 20100101

Title: Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.

Journal: Chinese medicine 20100101

Title: Inhibition of P-glycoprotein at the blood-brain barrier by phytochemicals derived from traditional Chinese medicine.

Journal: Cancer genomics & proteomics 20100101

Title: Pheromone-induced life-history shifts A novel approach to controlling invasive toads.

Journal: Communicative & integrative biology 20100101

Title: Anti-hepatitis B virus activities of cinobufacini and its active components bufalin and cinobufagin in HepG2.2.15 cells.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Human tumor cell sensitivity to oleandrin is dependent on relative expression of Na+, K+ -ATPase subunitst.

Journal: Journal of experimental therapeutics & oncology 20100101

Title: Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer.

Journal: Cancer 20091115

Title: [Determination of plasma protein binding rate of bufalin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: Preparation and evaluation of lyophilized liposome-encapsulated bufadienolides.

Journal: Drug development and industrial pharmacy 20090901

Title: Sudden death associated with intravenous injection of toad extract.

Journal: Forensic science international 20090701

Title: Bufalin inhibits CYP3A4 activity in vitro and in vivo.

Journal: Acta pharmacologica Sinica 20090501

Title: Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 Cells.

Journal: Biotechnology letters 20090401

Title: FLIM and emission spectral analysis of caspase-3 activation inside single living cell during anticancer drug-induced cell death.

Journal: European biophysics journal : EBJ 20090401

Title: Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells.

Journal: The Journal of steroid biochemistry and molecular biology 20090401

Title: [Effects of Bufalin on SYK and CBL family proteins in induction of HL-60 cell apoptosis].

Journal: Zhongguo shi yan xue ye xue za zhi 20090201

Title: Simultaneous quantification of seven major bufadienolides in three traditional Chinese medicinal preparations of chansu by HPLC-DAD.

Journal: Natural product communications 20090201

Title: PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells.

Journal: Anti-cancer drugs 20090101

Title: Traditional Chinese Medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

Journal: PloS one 20090101

Title: Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells.

Journal: Cancer science 20081201

Title: [The influence of bortezomib on HL-60 cell function induced by all-trans retinoic acid plus bufalin and its mechanism].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20081201

Title: Agents from amphibians with anticancer properties.

Journal: Anti-cancer drugs 20081101

Title: Characterization of in vivo metabolites of toad venom using liquid chromatography-mass spectrometry.

Journal: Journal of chromatographic science 20080701

Title: [Determination of apparent aqueous solubility and apparent oil-water partition coefficients of three bufadienolides composition].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

Title: Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.

Journal: International journal of molecular medicine 20080501

Title: Simultaneous determination of three bufadienolides in rat plasma after intravenous administration of bufadienolides extract by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry.

Journal: Analytica chimica acta 20080310

Title: [Determination of three bufogenins in toad venom using reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20080301

Title: Up-regulation of the Cbl family of ubiquitin ligases is involved in ATRA and bufalin-induced cell adhesion but not cell differentiation.

Journal: Biochemical and biophysical research communications 20080227

Title: Effect of Chinese medicines Chan Su and Lu-Shen-Wan on serum digoxin measurement by Digoxin III, a new digoxin immunoassay.

Journal: Therapeutic drug monitoring 20080201

Title: Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine ChanSu.

Journal: Journal of chromatographic science 20080101

Title: Gene expression in Pre-MBT embryos and activation of maternally-inherited program of apoptosis to be executed at around MBT as a fail-safe mechanism in Xenopus early embryogenesis.

Journal: Gene regulation and systems biology 20080101

Title: Diverse biological responses to different cardiotonic steroids.

Journal: Pathophysiology : the official journal of the International Society for Pathophysiology 20071201

Title: Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

Journal: Integrative cancer therapies 20071201

Title: Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR).

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: Simultaneous determination of five main active bufadienolides of Chan Su in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115

Title: Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis.

Journal: American journal of physiology. Cell physiology 20070901

Title: Membrane dielectric responses of bufalin-induced apoptosis in HL-60 cells detected by an electrorotation chip.

Journal: Biotechnology letters 20070901

Title: Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

Journal: American journal of physiology. Cell physiology 20070801

Title: Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice.

Journal: World journal of gastroenterology 20070628

Title: Study of the determination and pharmacokinetics of bufadienolides in dog's plasma after administration of Liu-Shen-Wan by high performance liquid chromatography time-of-flight mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Electrokinetic measurements of dielectric properties of membrane for apoptotic HL-60 cells on chip-based device.

Journal: Biomedical microdevices 20070601

Title: Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines.

Journal: Acta pharmacologica Sinica 20070501

Title: [Inhibition action of bufalin on human transplanted hepatocellular tumor and its effects on expressions of Bcl-2 and Bax proteins in nude mice].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070301

Title: [Effect of bufalin-inducing apoptosis on Bcl-2 and PKC in HL-60 cells].

Journal: Zhongguo shi yan xue ye xue za zhi 20070201

Title: Involvement of Tiam1 in apoptosis induced by bufalin in HeLa cells.

Journal: Anticancer research 20070101

Title: Short-term effects of cardiac steroids on intracellular membrane traffic in neuronal NT2 cells.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20061230

Title: Characterization of in vitro metabolites of toad venom using high-performance liquid chromatography and liquid chromatography-mass spectrometry.

Journal: Biomedical chromatography : BMC 20061201

Title: [Enhancement of all-trans retinoic acid-induced differentiation by bufalin in primary culture of acute promyelocytic leukemia cells].

Journal: Zhonghua nei ke za zhi 20060401

Title: Oleandrin-mediated oxidative stress in human melanoma cells.

Journal: Journal of experimental therapeutics & oncology 20060101

Title: [Downregulation of Bcl-2 and survivin expression and release of Smac/DIABLO involved in bufalin-induced HL-60 cell apoptosis].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20060101

Title: Enhancement of ligand-dependent vitamin D receptor transactivation by the cardiotonic steroid bufalin.

Journal: Biochemical pharmacology 20051115

Title: Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an 'in vitro' replicative system.

Journal: Antiviral research 20051101

Title: Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis.

Journal: Molecular human reproduction 20051101

Title: Changing characteristics of the TDx digoxin II assay in detecting bufadienolides in a traditional Chinese medicine: for better or worse?

Journal: Therapeutic drug monitoring 20051001

Title: Na/K-ATPase, endogenous digitalis like compounds and cancer development -- a hypothesis.

Journal: Frontiers in bioscience : a journal and virtual library 20050901

Title: Substrate specificity for the 12beta-hydroxylation of bufadienolides by Alternaria alternata.

Journal: Journal of biotechnology 20050525

Title: Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus.

Journal: Journal of natural products 20050401

Title: Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells.

Journal: The Journal of biological chemistry 20050107

Title: Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.

Journal: Journal of natural products 20041201

Title: Characterization of the neutralizing activity of digoxin-specific Fab toward ouabain-like steroids.

Journal: The Journal of pharmacology and experimental therapeutics 20040701

Title: [Basic studies for the development of anticancer, antidementia, and taste modifier drugs].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040701

Title: Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography.

Journal: Biomedical chromatography : BMC 20040601

Title: Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure-activity relationships.

Journal: The Journal of steroid biochemistry and molecular biology 20040601

Title: Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells.

Journal: DNA repair 20031209

Title: [Dynamic effect of low frequency complex impulse current on transdermal absorption of secretio bufonis].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031001

Title: [Advances in the study of tumor angiogenesis and anti-angiogenic Chinese herbal drugs].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030501

Title: Study on mechanism of action of Chinese medicine Chan Su: dose-dependent biphasic production of nitric oxide in trophoblastic BeWo cells.

Journal: Clinica chimica acta; international journal of clinical chemistry 20030401

Title: Nongastric H,K-ATPase: structure and functional properties.

Journal: Annals of the New York Academy of Sciences 20030401

Title: Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells.

Journal: The Prostate 20030201

Title: Effects of Chan Su, a traditional Chinese medicine, on the calcium transients of isolated cardiomyocytes: cardiotoxicity due to more than Na, K-ATPase blocking.

Journal: Life sciences 20021227

Title: Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.

Journal: Journal of medicinal chemistry 20020718

Title: WT1 downregulation during K562 cell differentiation and apoptosis induced by bufalin.

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020701

Title: A comparative study of genotoxic effects of anti-topoisomerase II drugs ICRF-193 and bufalin in Chinese hamster ovary cells.

Journal: Mutation research 20020325

Title: Studies on toad venom (3): effect of metals on the quality of toad venom torrefied on a metal plate.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020101

Title: Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells.

Journal: Blood cells, molecules & diseases 20020101

Title: Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.

Journal: Mutation research 20011018

Title: Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

Journal: Journal of natural products 20010901

Title: Distinct PKC isozymes regulate bufalin-induced differentiation and apoptosis in human monocytic cells.

Journal: American journal of physiology. Cell physiology 20010301

Title: Determination of bufalin-like immunoreactivity in serum of humans and rats by time-resolved fluoroimmunoassay for using a monoclonal antibody.

Journal: Life sciences 20010126

Title: Digitoxin medication and cancer; case control and internal dose-response studies.

Journal: BMC cancer 20010101

Title: [Preliminary study on apoptosis of human leukemic cells induced by bufalin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010101

Title: ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells.

Journal: American journal of physiology. Cell physiology 20000301

Title: Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells.

Journal: Leukemia research 19950801

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Tags:465-21-4 Molecular Formula|465-21-4 MDL|465-21-4 SMILES|465-21-4 Bufalin