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465-39-4,MFCD00210361
Catalog No.:AA00I8I0

465-39-4 | Resibufogenin

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1mg
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$52.00   $36.00
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5mg
≥98%
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$192.00   $134.00
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10mg
≥98%
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$282.00   $197.00
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20mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I8I0
Chemical Name:
Resibufogenin
CAS Number:
465-39-4
Molecular Formula:
C24H32O4
Molecular Weight:
384.5085
MDL Number:
MFCD00210361
SMILES:
O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@]31O[C@@H]3C[C@@H]2c1ccc(=O)oc1)C)C
Properties
Computed Properties
 
Complexity:
786  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.7  

Literature

Title: Marinobufagenin predicts and resibufogenin prevents preeclampsia: a review of the evidence.

Journal: American journal of perinatology 20121101

Title: Separation and determination of resibufogenin and cinobufagin in Chansu using reversed-phase liquid chromatography with γ-cyclodextrin as mobile-phase modifier.

Journal: Journal of separation science 20120801

Title: Bufothionine, a possible effective component in cinobufocini injection for hepatocellular carcinoma.

Journal: Journal of ethnopharmacology 20120601

Title: Configurational reassignment and improved preparation of the competitive IL-6 receptor antagonist 20R,21R-epoxyresibufogenin-3-formate.

Journal: Journal of natural products 20120427

Title: Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components.

Journal: Chemico-biological interactions 20120125

Title: Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia.

Journal: Hypertension in pregnancy 20120101

Title: Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111201

Title: Novel microbial transformation of resibufogenin by Absidia coerules.

Journal: Natural product communications 20111101

Title: Novel microbial transformation of resibufogenin by Fusarium solani.

Journal: Journal of Asian natural products research 20110901

Title: Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons.

Journal: Neuroscience letters 20110826

Title: Marinobufagenin is an upstream modulator of Gadd45a stress signaling in preeclampsia.

Journal: Biochimica et biophysica acta 20110101

Title: Marinobufagenin, resibufogenin and preeclampsia.

Journal: Biochimica et biophysica acta 20101201

Title: Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection.

Journal: Journal of pharmaceutical and biomedical analysis 20101102

Title: Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS.

Journal: Journal of ethnopharmacology 20100915

Title: Emerging role of the bufadienolides in cardiovascular and kidney diseases.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20100801

Title: Preparative separation of four major bufadienolides from the Chinese traditional medicine, Chansu, using high-speed counter-current chromatography.

Journal: Natural product communications 20100701

Title: [Study on quality standards for Lingmaoxiang Jiedu pills].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201

Title: Resibufogenin prevents the manifestations of preeclampsia in an animal model of the syndrome.

Journal: Hypertension in pregnancy 20100101

Title: Contribution of angiogenic factors in a rat model of pre-eclampsia.

Journal: American journal of nephrology 20100101

Title: Sudden death associated with intravenous injection of toad extract.

Journal: Forensic science international 20090701

Title: [Determination of apparent aqueous solubility and apparent oil-water partition coefficients of three bufadienolides composition].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

Title: [Determination of three bufogenins in toad venom using reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20080301

Title: Effects of resibufogenin in experimental hypertension.

Journal: American journal of nephrology 20080101

Title: Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine ChanSu.

Journal: Journal of chromatographic science 20080101

Title: Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR).

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: Characterization of in vitro metabolites of toad venom using high-performance liquid chromatography and liquid chromatography-mass spectrometry.

Journal: Biomedical chromatography : BMC 20061201

Title: Rapid separation and determination of resibufogenin and cinobufagin in toad venom and Liushen tablet by beta-cyclodextrin modified micellar electrokinetic chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20060411

Title: Microemulsion electrokinetic chromatographic determination of bufadienolides in toad venom and in traditional Chinese medicine.

Journal: Analytical and bioanalytical chemistry 20060301

Title: Efficient preparation of derivatives of resibufogenin using microbial catalytic technique.

Journal: Planta medica 20060301

Title: Resibufogenin corrects hypertension in a rat model of human preeclampsia.

Journal: Experimental biology and medicine (Maywood, N.J.) 20060201

Title: Quality evaluation of traditional Chinese drug toad venom from different origins through a simultaneous determination of bufogenins and indole alkaloids by HPLC.

Journal: Chemical & pharmaceutical bulletin 20051201

Title: Substrate specificity for the 12beta-hydroxylation of bufadienolides by Alternaria alternata.

Journal: Journal of biotechnology 20050525

Title: Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.

Journal: Journal of natural products 20041201

Title: Isolation and structure of a 20,21-epoxybufenolide series from 'Ch'an Su'.

Journal: Journal of natural products 20020701

Title: Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

Journal: Journal of natural products 20010901

Title: Cardiac toxicity of resibufogenin: electrophysiological evidence.

Journal: Acta pharmacologica Sinica 20010401

Title: Hao S, et al. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol In Vitro. 2011 Dec;25(8):1644-53.

Title: Uddin MN, et al. Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia. Hypertens Pregnancy. 2012;31(1):70-8.

Title: Ichikawa M, et al. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS One. 2015 Jun 29;10(6):e0129851.

Title: Hao S, et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 2011 Aug 26;501(2):112-6.

Title: Zheng J, et al. Novel microbial transformation of resibufogenin by Absidia coerules. Nat Prod Commun. 2011 Nov;6(11):1581-4.

Title: Xin XL, et al. Novel microbial transformation of resibufogenin by Fusarium solani. J Asian Nat Prod Res. 2011 Sep;13(9):831-7.

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