[1]JournaloftheAmericanChemicalSociety,2007,vol.129,#14,p.4144-4145
[2]JournalofOrganicChemistry,2007,vol.72,#18,p.7058-7061
[1]JournaloftheAmericanChemicalSociety,2012,vol.134,#42,p.17490-17493,4
[1]JournaloftheIndianChemicalSociety,1979,vol.56,#7,p.708-711
[1]JournaloftheIndianChemicalSociety,1979,vol.56,p.708-711
[1]JournaloftheAmericanChemicalSociety,2007,vol.129,p.4144-4145
[1]JournaloftheAmericanChemicalSociety,2007,vol.129,p.4144-4145
[2]JournalofOrganicChemistry,2007,vol.72,p.7058-7061
108-59-8
[1]JournalofOrganicChemistry,2007,vol.72,p.7058-7061
[1]JournaloftheAmericanChemicalSociety,2012,vol.134,p.17490-17493,4
1-Methyl-7-nitroisatoic anhydride (1M7) functions as an in vivo SHAPE-MaP reagent, enabling live cell RNA structure analysis with single nucleotide resolution. In the SHAPE method, 1M7, a small electrophilic chemical probe, reacts selectively with the 2′-hydroxyl group of RNA molecules. This reaction provides valuable insights into RNA structure. When combined with mutational profiling (MaP), quantitative measurements of nucleotides across entire transcriptomes become feasible. These techniques enhance understanding of RNA interactions and identify regions that could be targeted for the design of RNA-targeting small-molecule drugs.
