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Home Other Building Blocks 856243-80-6
856243-80-6,MFCD18839228
Catalog No.:AA00G3NQ

856243-80-6 | Degrasyn (WP1130)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$34.00   $24.00
- +
5mg
≥95%
in stock  
$98.00   $68.00
- +
10mg
98+%
in stock  
$125.00   $88.00
- +
50mg
98+%
in stock  
$339.00   $238.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3NQ
Chemical Name:
Degrasyn (WP1130)
CAS Number:
856243-80-6
Molecular Formula:
C19H18BrN3O
Molecular Weight:
384.2697
MDL Number:
MFCD18839228
SMILES:
CCC[C@@H](c1ccccc1)NC(=O)/C(=C/c1cccc(n1)Br)/C#N
Properties
Computed Properties
 
Complexity:
490  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.3  

Downstream Synthesis Route

[1]Patent:US2012/77806,2012,A1.Locationinpatent:Page/Pagecolumn29;32

856243-80-6    27565-41-9   
3-(6-bromopyridin-2-yl)-2-cyano-3-(2,3-dihydroxy-4-mercaptobutylsulfanyl)-N-(1-phenylbutyl)propionamide 

[1]Patent:US2012/77806,2012,A1.Locationinpatent:Page/Pagecolumn29;32

856243-80-6    70024-90-7   
(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(S)-(1-phenylbutyl)acrylamide-HumanSerumAlbuminadduct 

[1]Patent:WO2015/183987,2015,A1.Locationinpatent:Paragraph00349

[1]ChemicalCommunications,2020,vol.56,p.2929-2932

[2]Patent:WO2015/183987,2015,A1.Locationinpatent:Paragraph00348

856243-80-6   
3-(6-bromopyridin-2-yl)-2-cyano-N-((S)-1-phenylbutyl)propanamide 

[1]ChemicalCommunications,2020,vol.56,p.2929-2932

Literature

Title: Vialinin A is a ubiquitin-specific peptidase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.

Journal: Cellular signalling 20111201

Title: Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma.

Journal: Bioorganic & medicinal chemistry 20111201

Title: Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Journal: Blood 20110317

Title: Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications.

Journal: Molecular cancer therapeutics 20100701

Title: Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells.

Journal: Blood 20070415

Title: Bartholomeusz GA, et al. Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. Blood. 2007 Apr 15;109(8):3470-8.

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SDS
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