Name: Name:Degrasyn (WP1130)
Brand: AABLOCKS
SKU: AA00G3NQ
Rating: 90 (10 reviews)

Catalog No.: AA00G3NQ

856243-80-6 | Degrasyn (WP1130)

Pack Size： 1mg

Purity： 98+%

in stock

$34.00 $24.00

Pack Size： 5mg

Purity： ≥95%

in stock

$98.00 $68.00

Pack Size： 10mg

Purity： 98+%

in stock

$127.00 $89.00

Pack Size： 50mg

Purity： 98+%

in stock

$344.00 $241.00

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Technical Information

Catalog Number: AA00G3NQ

Chemical Name: Degrasyn (WP1130)

CAS Number: 856243-80-6

Molecular Formula: C19H18BrN3O

Molecular Weight: 384.2697

MDL Number: MFCD18839228

SMILES: CCC[C@@H](c1ccccc1)NC(=O)/C(=C/c1cccc(n1)Br)/C#N

Properties

Complexity: 490

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 24

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.3

Downstream Synthesis Route

856243-80-6

96-27-5

1369506-58-0

[1]Patent:US2012/77806,2012,A1.Locationinpatent:Page/Pagecolumn29;32

856243-80-6

27565-41-9

3-(6-bromopyridin-2-yl)-2-cyano-3-(2,3-dihydroxy-4-mercaptobutylsulfanyl)-N-(1-phenylbutyl)propionamide

[1]Patent:US2012/77806,2012,A1.Locationinpatent:Page/Pagecolumn29;32

856243-80-6

70024-90-7

(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(S)-(1-phenylbutyl)acrylamide-HumanSerumAlbuminadduct

[1]Patent:WO2015/183987,2015,A1.Locationinpatent:Paragraph00349

34160-40-2

1240038-58-7

856243-80-6

[1]ChemicalCommunications,2020,vol.56,p.2929-2932

[2]Patent:WO2015/183987,2015,A1.Locationinpatent:Paragraph00348

856243-80-6

3-(6-bromopyridin-2-yl)-2-cyano-N-((S)-1-phenylbutyl)propanamide

[1]ChemicalCommunications,2020,vol.56,p.2929-2932

Literature fold

Title: Vialinin A is a ubiquitin-specific peptidase inhibitor.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.

Journal: Cellular signalling20111201

Title: Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma.

Journal: Bioorganic & medicinal chemistry20111201

Title: Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Journal: Blood20110317

Title: Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications.

Journal: Molecular cancer therapeutics20100701

Title: Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells.

Journal: Blood20070415

Title: Bartholomeusz GA, et al. Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. Blood. 2007 Apr 15;109(8):3470-8.

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