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851199-59-2,MFCD20526656
Catalog No.:AA00G3OH

851199-59-2 | Linaclotide

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Purity
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1mg
≥95%
in stock  
$82.00   $57.00
- +
5mg
≥95%
in stock  
$263.00   $184.00
- +
10mg
≥95%
in stock  
$472.00   $330.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G3OH
Chemical Name:
Linaclotide
CAS Number:
851199-59-2
Molecular Formula:
C59H79N15O21S6
Molecular Weight:
1526.7365
MDL Number:
MFCD20526656
SMILES:
OC(=O)CC[C@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](C)NC(=O)[C@H]4N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)O)CSSC[C@H](NC(=O)CNC(=O)C(NC3=O)[C@H](O)C)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CSSC[C@@H](C(=O)N2)N)CC(=O)N)CCC4
Properties
Computed Properties
 
Complexity:
3030  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
14  
Heavy Atom Count:
101  
Hydrogen Bond Acceptor Count:
28  
Hydrogen Bond Donor Count:
19  
Rotatable Bond Count:
13  
XLogP3:
-6.8  

Literature

Title: Current and emerging treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation: focus on prosecretory agents.

Journal: Pharmacotherapy 20150601

Title: Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome.

Journal: Expert opinion on drug metabolism & toxicology 20130401

Title: Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation.

Journal: The Journal of pharmacology and experimental therapeutics 20130101

Title: Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis.

Journal: Drug design, development and therapy 20130101

Title: Linaclotide: first global approval.

Journal: Drugs 20121112

Title: Recent advances in the management of difficult constipation.

Journal: Current gastroenterology reports 20120801

Title: Linaclotide in the management of gastrointestinal tract disorders.

Journal: Drugs of today (Barcelona, Spain : 1998) 20120301

Title: Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors.

Journal: BMC pharmacology 20120101

Title: Linaclotide: a novel approach to the treatment of irritable bowel syndrome.

Journal: The Annals of pharmacotherapy 20111201

Title: Chronic constipation: current treatment options.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20111001

Title: New treatment options for chronic constipation: mechanisms, efficacy and safety.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20111001

Title: Two randomized trials of linaclotide for chronic constipation.

Journal: The New England journal of medicine 20110811

Title: Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation.

Journal: Expert review of gastroenterology & hepatology 20110601

Title: The pharmacokinetics, pharmacodynamics, clinical efficacy, safety and tolerability of linaclotide.

Journal: Expert opinion on drug metabolism & toxicology 20110501

Title: Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis.

Journal: Gut 20110201

Title: IBS in 2010: advances in pathophysiology, diagnosis and treatment.

Journal: Nature reviews. Gastroenterology & hepatology 20110201

Title: Optimized Fmoc solid-phase synthesis of the cysteine-rich peptide linaclotide.

Journal: Biopolymers 20110101

Title: Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.

Journal: European journal of pharmacology 20101215

Title: Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation.

Journal: Gastroenterology 20101201

Title: Emerging pharmacologic therapies for irritable bowel syndrome.

Journal: Current gastroenterology reports 20101001

Title: Molecule of the month. Linaclotide acetate.

Journal: Drug news & perspectives 20101001

Title: Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics.

Journal: Toxins 20100801

Title: Constipation: Linaclotide--a stimulating new drug for chronic constipation.

Journal: Nature reviews. Gastroenterology & hepatology 20100701

Title: [New drugs for the treatment of constipation].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20100701

Title: Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.

Journal: Life sciences 20100508

Title: Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100301

Title: Efficacy of linaclotide for patients with chronic constipation.

Journal: Gastroenterology 20100301

Title: Taking a lesson from microbial diarrheagenesis in the management of chronic constipation.

Journal: Gastroenterology 20100301

Title: Linaclotide - a secretagogue and antihyperalgesic agent - what next?

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100301

Title: The use of novel promotility and prosecretory agents for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation.

Journal: Advances in therapy 20090501

Title: Pilot study on the effect of linaclotide in patients with chronic constipation.

Journal: The American journal of gastroenterology 20090101

Title: Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.

Journal: Gastroenterology 20070901

Title: Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation.

Journal: Current opinion in molecular therapeutics 20070801

Title: Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19-20):760-5.

Title: Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91.

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